The intermediate age open cluster NGC 2660

We present CCD UBVI photometry of the intermediate old open cluster NGC2660, covering from the red giants region to about seven magnitudes below the main sequence turn-off. Using the synthetic Colour - Magnitude Diagram method, we estimate in a self-consistent way values for distance modulus ((m-M)0 ~= 12.2), reddening (E(B-V) ~= 0.40), metallicity ([Fe/H] about solar), and age (age ~ 1 Gyr). A 30% population of binary stars turns out to be probably present.Comment: 12 pages, 8 (encapsulated) figures, to be published on MNRA

Old open clusters: UBGVRI photometry of NGC 2506

UBGVRI photometry for the open cluster NGC 2506 is presented. From comparison of the observed colour-magnitude diagrams with simulations based on stellar evolutionary models we derive in a self consistent way reddening, distance, and age of the cluster: E(B-V)=0-0.07, (m-M)o = 12.6, age = 1.5-2.2 Gyr. The cluster shows a well definite secondary sequence, suggesting that binary systems constitute about 20 % of the cluster members visible in the colour-magnitude diagram.Comment: 11 pages, 7 figures, MNRAS latex style, accepte

Photometric and spectroscopic study of the intermediate age open cluster NGC 3960

We present CCD UBVI photometry and high-resolution spectroscopy of the intermediate age open cluster NGC 3960. The colour - magnitude diagrams (CMDs) derived from the photometric data and interpreted with the synthetic CMD method allow us to estimate the cluster parameters. We derive: age = 0.9 or 0.6 Gyr (depending on whether or not overshooting from convective regions is included in the adopted stellar models), distance (m-M)0 = 11.6 +/- 0.1, reddening E(B-V) = 0.29 +/- 0.02, differential reddening Delta E(B-V) = 0.05 and approximate metallicity between solar and half of solar. We obtained high resolution spectra of three clump stars, and derived an average [Fe/H] = -0.12 (rms 0.04 dex), in very good agreement with the photometric determination. We also obtained abundances of alpha-elements, Fe-peak elements, and of Ba. The reddenings toward individual stars derived from the spectroscopic temperatures and the Alonso et al. calibrations give further support to the existence of significative variations across the cluster.Comment: Accepted for publication on MNRAS; fig. 3, 4, 5, 6 at degraded resolutio

Many-body effective mass enhancement in a two-dimensional electron liquid

Motivated by a large number of recent magnetotransport studies we have revisited the problem of the microscopic calculation of the quasiparticle effective mass in a paramagnetic two-dimensional (2D) electron liquid (EL). Our systematic study is based on a generalized $GW$ approximation which makes use of the many-body local fields and takes advantage of the results of the most recent QMC calculations of the static charge- and spin-response of the 2D EL. We report extensive calculations for the many-body effective mass enhancement over a broad range of electron densities. In this respect we critically examine the relative merits of the on-shell approximation, commonly used in weak-coupling situations, {\it versus} the actual self-consistent solution of the Dyson equation. We show that already for $r_s \simeq 3$ and higher, a solution of the Dyson equation proves here necessary in order to obtain a well behaved effective mass. Finally we also show that our theoretical results for a quasi-2D EL, free of any adjustable fitting parameters, are in good qualitative agreement with some recent measurements in a GaAs/AlGaAs heterostructure.Comment: 12 pages, 3 figures, CMT28 Conference Proceedings, work related to cond-mat/041226

Adequate Antigen Availability: A Key Issue for Novel Approaches to Tumor Vaccination and Tumor Immunotherapy

A crucial parameter for activation of the anti-tumor immune response is an adequate antigen availability (AAA) defined here as the optimal tumor antigen dose and related antigen processing and MHC-II-restricted presentation necessary to efficiently trigger tumor-specific TH cells. We will discuss two distinct experimental systems: a) a preventive anti-tumor vaccination system; b) a therapy-induced anti-tumor vaccination approach. In the first case tumor cells are rendered constitutively MHC-II+ by transfecting them with the MHC-II transcriptional activator CIITA. Here AAA is generated by the function of tumor's newly expressed MHC-II molecules to present tumor-associated antigens to tumor-specific TH cells. In the second case, AAA is generated by treating established tumors with neovasculature-targeted TNF alpha. In conjuction with Melphalan, targeted TNF alpha delivery produces extensive areas of tumor necrosis that generate AAA capable of optimally activate tumor-specific TH cells which in turn activate CTL immune effectors. In both experimental systems tumor rejection and persistent and long-lived TH cell anti-tumor memory, responsible of defending the animals from subsequent challenges with tumor cells, are achieved. Based on these and other investigators' results we propose that AAA is a key element for triggering adaptive immune functions resulting in subversion from a pro-tumor to an anti-tumor microenvironment, tumor rejection and acquisition of anti-tumor immune memory. Hypotheses of neuro-immune networks involved in these approaches are discussed. These considerations are important also for the comprehension of how chemotherapy and/or radiation therapies may help to block and/or to eradicate the tumor and for the construction of suitable anti-tumor vaccine strategies