435 research outputs found
ΠΠΏΡΡ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΏΠΎΠ»Π½ΠΎΡΠ΅ΠΊΡΡΠΎΠ²ΠΎΠΉ Π±Π°Π·Ρ Π΄Π°Π½Π½ΡΡ Β«ΠΠ΅Π΄ΠΠΈΠ±Β» Π² Π½Π°ΡΡΠ½ΠΎ-ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊΠ΅ Π‘ΠΈΠ±ΠΈΡΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ°
.
ΠΡΡΠΎΡΠΈΠ°ΡΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π³Π΅Π½ΠΎΠ² ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² (TNF ΠΈ IL8) Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
The association of the tumor necrosis TNF-Ξ± β308G/A polymorphism and interleukin-8 genetic IL8 β251Π/Π’ polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the structure of COLD susceptibility have been obtained. In Siberian Tatars, the TNF β308G allelic variant plays a role in the COLD development. In Russians, no association of the studied genetic markers with COLD was reveled.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° β308G/A Π³Π΅Π½Π° ΡΠ°ΠΊΡΠΎΡΠ° Π½Π΅ΠΊΡΠΎΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Ξ± (TNF) ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° β251Π/Π’ Π³Π΅Π½Π° IL8 Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
(Π₯ΠΠΠ) Π² Π΄Π²ΡΡ
ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
Π³. Π’ΠΎΠΌΡΠΊΠ° (ΡΠΈΠ±ΠΈΡΡΠΊΠΈΠ΅ ΡΠ°ΡΠ°ΡΡ ΠΈ ΡΡΡΡΠΊΠΈΠ΅). ΠΠΎΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΠΌΠ΅ΠΆΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π·Π»ΠΈΡΠΈΡΡ
Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ Π₯ΠΠΠ. Π£ ΡΠΈΠ±ΠΈΡΡΠΊΠΈΡ
ΡΠ°ΡΠ°Ρ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈΠ³ΡΠ°Π΅Ρ ΡΠΎΠ»Ρ Π°Π»Π»Π΅Π»ΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ β308G/A Π³Π΅Π½Π° TNF. Π£ ΡΡΡΡΠΊΠΈΡ
Π½Π΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΡ
Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Ρ Π₯ΠΠΠ
ΠΠ½Π°Π»ΠΈΠ· Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² TNF ΠΈ IL8 Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
The correlation of the 308G/A polymorphism of Ξ± TNF (tumor necrosis factor) gene and 251Π/Π’ polymorphism of 8 IL8 (interleukin 8) gene with clinical peculiarities of the course of chronic obstructive lung disease (COLD) in Siberian Tatars and Russians has been studied. Associations of these genetic markers with quantitative indices pathogenetically significant in the COLD formation (biochemical and immunological indices of blood serum and sputum) have been analyzed.The analysis of associations of polymorphous versions of TNF and IL8 genes with biochemical and immunological indices of blood serum and sputum has revealed the presence of interethnic peculiarities in the regulation of the level of proinflammatory and protective mechanisms participating in the formation of chronic inflammation at COLD.ΠΠ·ΡΡΠ΅Π½Π° Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° β308G/A Π³Π΅Π½Π° ΡΠ°ΠΊΡΠΎΡΠ° Π½Π΅ΠΊΡΠΎΠ·Π° ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Ξ± (TNF) ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° β251Π/Π’ Π³Π΅Π½Π° ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-8 (IL8) Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
(Π₯ΠΠΠ) Ρ ΡΠΈΠ±ΠΈΡΡΠΊΠΈΡ
ΡΠ°ΡΠ°Ρ ΠΈ ΡΡΡΡΠΊΠΈΡ
. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΉ Π΄Π°Π½Π½ΡΡ
Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ, ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π₯ΠΠΠ (Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΠΊΡΠΎΡΡ).ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΉ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π³Π΅Π½ΠΎΠ² TNF ΠΈ IL8 Ρ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΠΊΡΠΎΡΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΌΠ΅ΠΆΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΡΠΎΠ²Π½Ρ ΠΏΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈ Π·Π°ΡΠΈΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΠΈΠ³ΡΠ°ΡΡΠΈΡ
ΡΠΎΠ»Ρ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡ ΠΏΡΠΈ Π₯ΠΠΠ
ΠΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3β4 generations, genotyping on the most wide-spread Ξ±1-proteinase inhibitor (Ξ±1-PI) gene alleles (M, S, Z), definition of the Ξ±1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery Ξ±1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΎΠ»ΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ
ΠΈ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π»Π΅Π³ΠΊΠΈΡ
(Π₯ΠΠΠ) Ρ 100 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (50 β Π³ΡΡΠΏΠΏΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ) ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π³Π΅Π½Π΅Π°Π»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π΅ ΡΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΡΠΎΠ΄ΠΎΡΠ»ΠΎΠ²Π½ΡΡ
Ρ Π°Π½Π°Π»ΠΈΠ·ΠΎΠΌ 3β4 ΠΏΠΎΠΊΠΎΠ»Π΅Π½ΠΈΠΉ, Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π° Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠ΅ Π°Π»Π»Π΅Π»ΠΈ Π³Π΅Π½Π° Ξ±1-ΠΏΡΠΎΡΠ΅ΠΈΠ½Π°Π·Π½ΠΎΠ³ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ° (Ξ±1-ΠΠ) (M, S, Z), ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Ξ±1-ΠΠ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ. Π ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π₯ΠΠΠ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΡΠΎΠ»Ρ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² (ΠΊΡΡΠ΅Π½ΠΈΠ΅, ΠΏΠΎΠ»Π»ΡΡΠ°Π½ΡΡ), Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ Ξ±1-ΠΠ ΠΈΠΌΠ΅Π» ΠΌΠ΅ΡΡΠΎ ΡΠΎΠ»ΡΠΊΠΎ Ρ 6% Π±ΠΎΠ»ΡΠ½ΡΡ
Π₯ΠΠΠ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π΄ΡΡΠ³ΠΈΡ
Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π»ΠΎΠΊΡΡΠΎΠ² Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π₯ΠΠΠ
Search for directional associations between Baikal Gigaton Volume Detector neutrino-induced cascades and high-energy astrophysical sources
Baikal-GVD has recently published its first measurement of the diffuse
astrophysical neutrino flux, performed using high-energy cascade-like events.
We further explore the Baikal-GVD cascade dataset collected in 2018-2022, with
the aim to identify possible associations between the Baikal-GVD neutrinos and
known astrophysical sources. We leverage the relatively high angular resolution
of the Baikal-GVD neutrino telescope (2-3 deg.), made possible by the use of
liquid water as the detection medium, enabling the study of astrophysical point
sources even with cascade events. We estimate the telescope's sensitivity in
the cascade channel for high-energy astrophysical sources and refine our
analysis prescriptions using Monte-Carlo simulations. We primarily focus on
cascades with energies exceeding 100 TeV, which we employ to search for
correlation with radio-bright blazars. Although the currently limited neutrino
sample size provides no statistically significant effects, our analysis
suggests a number of possible associations with both extragalactic and Galactic
sources. Specifically, we present an analysis of an observed triplet of
neutrino candidate events in the Galactic plane, focusing on its potential
connection with certain Galactic sources, and discuss the coincidence of
cascades with several bright and flaring blazars.Comment: 10 pages, 3 figure
Large neutrino telescope Baikal-GVD: recent status
The Baikal-GVD is a deep-underwater neutrino telescope being constructed in
Lake Baikal. After the winter 2023 deployment campaign the detector consists of
3456 optical modules installed on 96 vertical strings. The status of the
detector and progress in data analysis are discussed in present report. The
Baikal-GVD data collected in 2018-2022 indicate the presence of cosmic neutrino
flux in high-energy cascade events consistent with observations by the IceCube
neutrino telescope. Analysis of track-like events results in identification of
first high-energy muon neutrino candidates. These and other results from
2018-2022 data samples are reviewed in this report
Studies of the ambient light of deep Baikal waters with Baikal-GVD
The Baikal-GVD neutrino detector is a deep-underwater neutrino telescope
under construction and recently after the winter 2023 deployment it consists of
3456 optical modules attached on 96 vertical strings. This 3-dimensional array
of photo-sensors allows to observe ambient light in the vicinity of the
Baikal-GVD telescope that is associated mostly with water luminescence. Results
on time and space variations of the luminescent activity are reviewed based on
data collected in 2018-2022
Monitoring of optical properties of deep waters of Lake Baikal in 2021-2022
We present the results of the two-year (2021-2022) monitoring of absorption
and scattering lengths of light with wavelength 400-620 nm within the effective
volume of the deep underwater neutrino telescope Baikal-GVD, which were
measured by a device Baikal-5D No.2. The Baikal-5D No.2. was installed during
the 2021 winter expedition at a depth of 1180 m. The absorption and scattering
lengths were measured every week in 9 spectral points. The device Baikal-5D
No.2 also has the ability to measure detailed scattering and absorption
spectra. The data obtained make it possible to estimate the range of changes in
the absorption and scattering lengths over a sufficiently long period of time
and to investigate the relationship between the processes of changes in
absorption and scattering. An analysis was made of changes in absorption and
scattering spectra for the period 2021-2022
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