754 research outputs found
Industry 4.0 and sustainability: Towards conceptualization and theory
Both Industry 4.0 and sustainability have gained momentum in the academic, managerial and policy debate. Despite the relevance of the topics, the relation between Industry 4.0 and sustainability \u2013 revealed by many authors \u2013 is still unclear; literature is fragmented. This paper seeks to overcome this limit by developing a systematic literature review of 117 peer-reviewed journal articles. After descriptive and content analyses, the work presents a conceptualization and theoretical framework. The paper contributes to both theory and practice by advancing current understanding of Industry 4.0 and sustainability, especially the impact of Industry 4.0 technologies on sustainability practices and performance
Seismic resilience of road bridges: lessons learned from the 14 November 2016 Kaikoura Earthquake
ABSTRACT: The 14th of November 2016 KaikĹŤura Earthquake sequence has highly affected the transport infrastructure in New Zealand. From the perspective of life-safety, the overall bridge performance was satisfactory; however, based on the observed undesirable sub-system performance of the damaged bridges, further investigation into possible improvements of the current design philosophy was warranted.
This paper describes the structural performance of the most severely damaged bridges during the KaikĹŤura Earthquake. The study is based on observations made during site inspections, on subsequent computational analyses performed and on a functionality database collected during the period following the event. The paper also introduces resilience indicators as a tool to predict the lifecycle performance and functionality of bridges. Finally, conclusions on the resilience and functionality of the bridges in the aftermath of the earthquake are raised, highlighting the main performance issues and suggesting strategies and technologies to enhance their seismic resilience during future events
Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis
EPIC247098361b: a transiting warm Saturn on an eccentric days orbit around a star
We report the discovery of EPIC247098361b using photometric data of the
Kepler K2 satellite coupled with ground-based spectroscopic observations.
EPIC247098361b has a mass of M M, a radius of
R R, and a moderately low equilibrium temperature of
K due to its relatively large star-planet separation of
AU. EPIC247098361b orbits its bright () late F-type host star
in an eccentric orbit () every 11.2 days, and is one of only
four well characterized warm Jupiters having hosts stars brighter than .
We estimate a heavy element content of 20 7 M for
EPIC247098361b, which is consistent with standard models of giant planet
formation. The bright host star of EPIC247098361b makes this system a well
suited target for detailed follow-up observations that will aid in the study of
the atmospheres and orbital evolution of giant planets at moderate separations
from their host stars.Comment: 11 pages, 10 figures, submitted to MNRA
Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection
The commensal microbiota impacts specific immune cell populations and their functions at peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut microbiota control immunity through regulation of hematopoiesis at primary immune sites. We reveal that germ-free mice display reduced proportions and differentiation potential of specific myeloid cell progenitors of both yolk sac and bone marrow origin. Homeostatic innate immune defects may lead to impaired early responses to pathogens. Indeed, following systemic infection with Listeria monocytogenes, germ-free and oral-antibiotic-treated mice display increased pathogen burden and acute death. Recolonization of germ-free mice with a complex microbiota restores defects in myelopoiesis and resistance to Listeria. These findings reveal that gut bacteria direct innate immune cell development via promoting hematopoiesis, contributing to our appreciation of the deep evolutionary connection between mammals and their microbiota
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