3,966 research outputs found
High Dimensional Classification with combined Adaptive Sparse PLS and Logistic Regression
Motivation: The high dimensionality of genomic data calls for the development
of specific classification methodologies, especially to prevent over-optimistic
predictions. This challenge can be tackled by compression and variable
selection, which combined constitute a powerful framework for classification,
as well as data visualization and interpretation. However, current proposed
combinations lead to instable and non convergent methods due to inappropriate
computational frameworks. We hereby propose a stable and convergent approach
for classification in high dimensional based on sparse Partial Least Squares
(sparse PLS). Results: We start by proposing a new solution for the sparse PLS
problem that is based on proximal operators for the case of univariate
responses. Then we develop an adaptive version of the sparse PLS for
classification, which combines iterative optimization of logistic regression
and sparse PLS to ensure convergence and stability. Our results are confirmed
on synthetic and experimental data. In particular we show how crucial
convergence and stability can be when cross-validation is involved for
calibration purposes. Using gene expression data we explore the prediction of
breast cancer relapse. We also propose a multicategorial version of our method
on the prediction of cell-types based on single-cell expression data.
Availability: Our approach is implemented in the plsgenomics R-package.Comment: 9 pages, 3 figures, 4 tables + Supplementary Materials 8 pages, 3
figures, 10 table
Snow spectral albedo at Summit, Greenland: measurements and numerical simulations based on physical and chemical properties of the snowpack
The broadband albedo of surface snow is determined both by the near-surface profile of the physical and chemical properties of the snowpack and by the spectral and angular characteristics of the incident solar radiation. Simultaneous measurements of the physical and chemical properties of snow were carried out at Summit Camp, Greenland (72°36ÂŽ N, 38°25ÂŽ W, 3210 m a.s.l.) in May and June 2011, along with spectral albedo measurements. One of the main objectives of the field campaign was to test our ability to predict snow spectral albedo by comparing the measured albedo to the albedo calculated with a radiative transfer model, using measured snow physical and chemical properties. To achieve this goal, we made daily measurements of the snow spectral albedo in the range 350â2200 nm and recorded snow stratigraphic information down to roughly 80 cm. The snow specific surface area (SSA) was measured using the DUFISSS instrument (DUal Frequency Integrating Sphere for Snow SSA measurement, Gallet et al., 2009). Samples were also collected for chemical analyses including black carbon (BC) and dust, to evaluate the impact of light absorbing particulate matter in snow. This is one of the most comprehensive albedo-related data sets combining chemical analysis, snow physical properties and spectral albedo measurements obtained in a polar environment. The surface albedo was calculated from density, SSA, BC and dust profiles using the DISORT model (DIScrete Ordinate Radiative Transfer, Stamnes et al., 1988) and compared to the measured values. Results indicate that the energy absorbed by the snowpack through the whole spectrum considered can be inferred within 1.10%. This accuracy is only slightly better than that which can be obtained considering pure snow, meaning that the impact of impurities on the snow albedo is small at Summit. In the near infrared, minor deviations in albedo up to 0.014 can be due to the accuracy of radiation and SSA measurements and to the surface roughness, whereas deviations up to 0.05 can be explained by the spatial heterogeneity of the snowpack at small scales, the assumption of spherical snow grains made for DISORT simulations and the vertical resolution of measurements of surface layer physical properties. At 1430 and around 1800 nm the discrepancies are larger and independent of the snow properties; we propose that they are due to errors in the ice refractive index at these wavelengths. This work contributes to the development of physically based albedo schemes in detailed snowpack models, and to the improvement of retrieval algorithms for estimating snow properties from remote sensing data
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In a genetic screen of a panel of recombinant inbred mice we previously identified Fgf15, expressed in neurons of the dorsomedial hypothalamus (DMH), as a negative regulator of glucagon secretion. Here, we report on the generation of Fgf15 <sup>CretdTomato</sup> mice and their use to further characterize these neurons. We show that they were glutamatergic and comprised glucose-inhibited and glucose-excited neurons. When activated by chemogenetics, Fgf15 neurons prevented the increase in vagal nerve firing and the secretion of glucagon normally triggered by insulin-induced hypoglycemia. On the other hand, they increased the activity of the sympathetic nerve in the basal state and prevented its silencing by glucose overload. Higher sympathetic tone increased hepatic Creb1 phosphorylation, Pck1 mRNA expression, and hepatic glucose production leading to glucose intolerance. Thus, Fgf15 neurons of the DMH participate in the counterregulatory response to hypoglycemia by a direct adrenergic stimulation of hepatic glucose production while suppressing vagally induced glucagon secretion. This study provides new insights into the complex neuronal network that prevents the development of hypoglycemia
Deep Radio Imaging of Globular Clusters and the Cluster Pulsar Population
We have obtained deep multifrequency radio observations of seven globular
clusters using the Very Large Array and the Australia Telescope Compact Array.
Five of these, NGC 6440, NGC 6539, NGC 6544, NGC 6624 and Terzan 5 had
previously been detected in a shallower survey for steep spectrum radio sources
in globular clusters (Fruchter and Goss 1990). The sixth, the rich globular
cluster, Liller 1, had heretofore been undetected in the radio, and the
seventh, 47 Tucanae, was not included in our original survey. High resolution 6
and 20 cm images of three of the clusters, NGC 6440, NGC 6539, NGC 6624 reveal
only point sources coincident with pulsars which have been discovered
subsequent to our first imaging survey. 21 and 18 cm images reveal several
point sources within a few core-radii of the center of 47 Tuc. Two of these are
identified pulsars, and a third, which is both variable and has a steep
spectrum, is also most likely a pulsar previously identified by a pulsed
survey. However, the 6, 20 and 90 cm images of NGC 6544, Liller 1 and Terzan 5
display strong steep-spectrum emission which cannot be associated with known
pulsars. The image of the rich cluster Terzan 5 displays numerous point sources
within , or 4 core radii of the cluster center. The density of these
objects rises rapidly toward the core, where an elongated region of emission is
found. The brightest individual sources, as well as the extended emission,
possess the steep spectra expected of pulsars. Furthermore, the flux
distribution of the sources agrees well with the standard pulsar luminosity
function. The total luminosity and number of objects observed suggest that
Terzan 5 contains more pulsars than any other Galactic globular cluster.Comment: 33 pages, 6 Postscript figures; Accepted for publication in the
Astrophysical Journal; abstract abridged. PDF version also available at
http://nemesis.stsci.edu/~fruchter/fg99/fg99.pd
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When Reporters get Hands-on with Robo-writing: Professionals Consider Automated Journalismâs Capabilities and Consequences
The availability of data feeds, the demand for news on digital devices, and advances in algorithms are helping to make automated journalism more prevalent. This article extends the literature on the subject by analysing professional journalistsâ experiences with, and opinions about, the technology. Uniquely, the participants were drawn from a range of news organizationsâincluding the BBC, CNN, and Thomson Reutersâand had first-hand experience working with robo-writing software provided by one of the leading technology suppliers. The results reveal journalistsâ judgements on the limitations of automation, including the nature of its sources and the sensitivity of its ânose for newsâ. Nonetheless, journalists believe that automated journalism will become more common, increasing the depth, breadth, specificity, and immediacy of information available. While some news organizations and consumers may benefit, such changes raise ethical and societal issues and, counter-intuitively perhaps, may increase the need for skillsânews judgement, curiosity, and scepticismâthat human journalists embody
Functional approach to 2+1 dimensional gravity coupled to particles
The quantum gravity problem of N point particles interacting with the
gravitational field in 2+1 dimensions is approached working out the phase-space
functional integral. The maximally slicing gauge is adopted for a non compact
open universe with the topology of the plane. The conjugate momenta to the
gravitational field are related to a class of meromorphic quadratic
differentials. The boundary term for the non compact space is worked out in
detail. In the extraction of the physical degrees of freedom functional
determinants related to the puncture formulation of string theory occur and
cancel out in the final reduction. Finally the ordering problem in the
definition of the functional integral is discussed.Comment: 29 pages LaTe
A Retinoic Acid Responsive Hoxa3 Transgene Expressed in Embryonic Pharyngeal Endoderm, Cardiac Neural Crest and a Subdomain of the Second Heart Field
A transgenic mouse line harbouring a ÎČ-galacdosidase reporter gene controlled by the proximal 2 kb promoter of Hoxa3 was previously generated to investigate the regulatory cues governing Hoxa3 expression in the mouse. Examination of transgenic embryos from embryonic day (E) 8.0 to E15.5 revealed regionally restricted reporter activity in the developing heart. Indeed, transgene expression specifically delineated cells from three distinct lineages: a subpopulation of the second heart field contributing to outflow tract myocardium, the cardiac neural crest cells and the pharyngeal endoderm. Manipulation of the Retinoic Acid (RA) signaling pathway showed that RA is required for correct expression of the transgene. Therefore, this transgenic line may serve as a cardiosensor line of particular interest for further analysis of outflow tract development
Brands in international and multiâplatform expansion strategies: economic and management issues
Powerful media branding has historically facilitated successful international expansion on the part of magazine and other content forms including film and TV formats. Multi-platform expansion is now increasingly central to the strategies of media companies and, as this chapter argues, effective use of branding in order to engage audiences effectively and to secure a prominent presence across digital platforms forms a core part of this. Drawing on original research into the experience of UK media companies, this chapter highlights some of the key economic, management and socio-cultural issues raised by the ever-increasing role of brands and branding in the strategies of international and multi-platform expansion that are increasingly common- place across media
Carthage
La Carthage punique (S. Lancel) Si, pour dater la fondation de Carthage par des PhĂ©niciens venus de Tyr en passant par Chypre, on ne prend pas en considĂ©ration une tradition haute -reprĂ©sentĂ©e en particulier par la Chronique de saint JĂ©rĂŽme â qui fixait en 1215 avant notre Ăšre cet Ă©vĂ©nement, on sâaccorde en gĂ©nĂ©ral sur une tradition « basse » qui retient pour cette fondation une date situĂ©e Ă la fin du ixe siĂšcle, plus prĂ©cisĂ©ment en 814 avant J.-C. Cette date, mentionnĂ©e aussi par CicĂ©ron da..
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