190 research outputs found
Permeability of a bubble assembly: From the very dry to the wet limit
We measure the permeability of a fluidized bed of monodispersed bubbles with
soap solution characteristic of mobile and non-mobile interfaces. These
experimental data extend the permeability curves previously published for foam
in the dry limit. In the wet limit, these data join the permeability curves of
a hard sphere suspension at porosity equal to 0.4 and 0.6 in the cases of
mobile and non-mobile interfaces respectively. We show that the model of
permeability proposed by Kozeny and Carman and originally validated for packed
beds of spheres (with porosity around 0.4) can be successfully applied with no
adjustable parameters to liquid fractions from 0.001 up to 0.85 for systems
made of monodisperse and deformable entities with non-mobile interfaces
Entropic Tightening of Vibrated Chains
We investigate experimentally the distribution of configurations of a ring
with an elementary topological constraint, a ``figure-8'' twist. Using vibrated
granular chains, which permit controlled preparation and direct observation of
such a constraint, we show that configurations where one of the loops is tight
and the second is large are strongly preferred. This agrees with recent
predictions for equilibrium properties of topologically-constrained polymers.
However, the dynamics of the tightening process weakly violate detailed
balance, a signature of the nonequilibrium nature of this system.Comment: 4 pages, 4 figure
Dynamics of electrostatically-driven granular media. Effects of Humidity
We performed experimental studies of the effect of humidity on the dynamics
of electrostatically-driven granular materials. Both conducting and dielectric
particles undergo a phase transition from an immobile state (granular solid) to
a fluidized state (granular gas) with increasing applied field. Spontaneous
precipitation of solid clusters from the gas phase occurs as the external
driving is decreased. The clustering dynamics in conducting particles is
primarily controlled by screening of the electric field but is aided by
cohesion due to humidity. It is shown that humidity effects dominate the
clustering process with dielectric particles.Comment: 4 pages, 4 fig
Scaling, Multiscaling, and Nontrivial Exponents in Inelastic Collision Processes
We investigate velocity statistics of homogeneous inelastic gases using the
Boltzmann equation. Employing an approximate uniform collision rate, we obtain
analytic results valid in arbitrary dimension. In the freely evolving case, the
velocity distribution is characterized by an algebraic large velocity tail,
P(v,t) ~ v^{-sigma}. The exponent sigma(d,epsilon), a nontrivial root of an
integral equation, varies continuously with the spatial dimension, d, and the
dissipation coefficient, epsilon. Although the velocity distribution follows a
scaling form, its moments exhibit multiscaling asymptotic behavior.
Furthermore, the velocity autocorrelation function decays algebraically with
time, A(t)= ~ t^{-alpha}, with a non-universal dissipation-dependent
exponent alpha=1/epsilon. In the forced case, the steady state Fourier
transform is obtained via a cumulant expansion. Even in this case, velocity
correlations develop and the velocity distribution is non-Maxwellian.Comment: 10 pages, 3 figure
The lactonase BxdA mediates metabolic specialisation of maize root bacteria to benzoxazinoids.
Root exudates contain specialised metabolites that shape the plant's root microbiome. How host-specific microbes cope with these bioactive compounds, and how this ability affects root microbiomes, remains largely unknown. We investigated how maize root bacteria metabolise benzoxazinoids, the main specialised metabolites of maize. Diverse and abundant bacteria metabolised the major compound in the maize rhizosphere MBOA (6-methoxybenzoxazolin-2(3H)-one) and formed AMPO (2-amino-7-methoxy-phenoxazin-3-one). AMPO forming bacteria were enriched in the rhizosphere of benzoxazinoid-producing maize and could use MBOA as carbon source. We identified a gene cluster associated with AMPO formation in microbacteria. The first gene in this cluster, bxdA encodes a lactonase that converts MBOA to AMPO in vitro. A deletion mutant of the homologous bxdA genes in the genus Sphingobium, did not form AMPO nor was it able to use MBOA as a carbon source. BxdA was identified in different genera of maize root bacteria. Here we show that plant-specialised metabolites select for metabolisation-competent root bacteria. BxdA represents a benzoxazinoid metabolisation gene whose carriers successfully colonize the maize rhizosphere and thereby shape the plant's chemical environmental footprint
108 AUROTHIOMALATE INHIBITS COX-2 EXPRESSION AND PGE2 PRODUCTION IN CHONDROCYTES BY INCREASING MKP-1 EXPRESSION AND DECREASING p38 AND JNK PHOSPHORYLATION
The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most interventions without evidence of attenuation or increase in risk at low LDL-C levels. Opportunities for innovation in dyslipidaemia treatment should address the substantial risk of lipid-associated cardiovascular events among patients optimally treated per guidelines but who cannot achieve LDL-C goals and who could benefit from additional LDL-C-lowering therapy or experience side effects of statins. Fresh approaches are needed to identify promising drug targets early and develop them efficiently. The Cardiovascular Round Table of the European Society of Cardiology (ESC) convened a workshop to discuss new lipid-lowering strategies for cardiovascular risk reduction. Opportunities to improve treatment approaches and the efficient study of new therapies were explored. Circulating biomarkers may not be fully reliable proxy indicators of the relationship between treatment effect and clinical outcome. Mendelian randomization studies may better inform development strategies and refine treatment targets before Phase 3. Trials should match the drug to appropriate lipid and patient profile, and guidelines may move towards a precision-based approach to individual patient management. Stakeholder collaboration is needed to ensure continued innovation and better international coordination of both regulatory aspects and guidelines. It should be noted that risk may also be addressed through increased attention to other risk factors such as smoking, hypertension, overweight, and inactivity
Soft Dynamics simulation: 2. Elastic spheres undergoing a T1 process in a viscous fluid
Robust empirical constitutive laws for granular materials in air or in a
viscous fluid have been expressed in terms of timescales based on the dynamics
of a single particle. However, some behaviours such as viscosity bifurcation or
shear localization, observed also in foams, emulsions, and block copolymer
cubic phases, seem to involve other micro-timescales which may be related to
the dynamics of local particle reorganizations. In the present work, we
consider a T1 process as an example of a rearrangement. Using the Soft dynamics
simulation method introduced in the first paper of this series, we describe
theoretically and numerically the motion of four elastic spheres in a viscous
fluid. Hydrodynamic interactions are described at the level of lubrication
(Poiseuille squeezing and Couette shear flow) and the elastic deflection of the
particle surface is modeled as Hertzian. The duration of the simulated T1
process can vary substantially as a consequence of minute changes in the
initial separations, consistently with predictions. For the first time, a
collective behaviour is thus found to depend on another parameter than the
typical volume fraction in particles.Comment: 11 pages - 5 figure
Global assessment of marine plastic exposure risk for oceanic birds
Plastic pollution is distributed patchily around the world's oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and non-breeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging species
Global assessment of marine plastic exposure risk for oceanic birds
Plastic pollution is distributed patchily around the world’s oceans. Likewise, marine organisms that are vulnerable to plastic ingestion or entanglement have uneven distributions. Understanding where wildlife encounters plastic is crucial for targeting research and mitigation. Oceanic seabirds, particularly petrels, frequently ingest plastic, are highly threatened, and cover vast distances during foraging and migration. However, the spatial overlap between petrels and plastics is poorly understood. Here we combine marine plastic density estimates with individual movement data for 7137 birds of 77 petrel species to estimate relative exposure risk. We identify high exposure risk areas in the Mediterranean and Black seas, and the northeast Pacific, northwest Pacific, South Atlantic and southwest Indian oceans. Plastic exposure risk varies greatly among species and populations, and between breeding and nonbreeding seasons. Exposure risk is disproportionately high for Threatened species. Outside the Mediterranean and Black seas, exposure risk is highest in the high seas and Exclusive Economic Zones (EEZs) of the USA, Japan, and the UK. Birds generally had higher plastic exposure risk outside the EEZ of the country where they breed. We identify conservation and research priorities, and highlight that international collaboration is key to addressing the impacts of marine plastic on wide-ranging speciespublishedVersio
Constraints on the decay of Ta
Ta is a rare nuclear isomer whose decay has never been observed. Its
remarkably long lifetime surpasses the half-lives of all other known
and electron capture decays due to the large K-spin differences and small
energy differences between the isomeric and lower energy states. Detecting its
decay presents a significant experimental challenge but could shed light on
neutrino-induced nucleosynthesis mechanisms, the nature of dark matter and
K-spin violation. For this study, we repurposed the MAJORANA DEMONSTRATOR, an
experimental search for the neutrinoless double-beta decay of Ge using
an array of high-purity germanium detectors, to search for the decay of
Ta. More than 17 kilograms, the largest amount of tantalum metal ever
used for such a search was installed within the ultra-low background detector
array. In this paper we present results from the first year of Ta data taking
and provide an updated limit for the Ta half-life on the different
decay channels. With new limits up to 1.5 x years, we improved
existing limits by one to two orders of magnitude. This result is the most
sensitive search for a single and electron capture decay ever achieved
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