63 research outputs found

    Infinite Atomized Semilattices

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    We extend the theory of atomized semilattices to the infinite setting. We show that it is well-defined and that every semilattice is atomizable. We also study atom redundancy, focusing on complete and finitely generated semilattices and show that for finitely generated semilattices, atomizations consisting exclusively of non-redundant atoms always exist.Comment: 25 pages, 2 figure

    Intramedullary Sclerosing Meningioma in Meningiomatosis: Case Report and Review of the Literature

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    Sclerosing meningioma is a rare histological variant of meningioma, first described in the literature by Davidson and Hope in 1989 as an invasive bulking mass consisted of whorling collagen bundles with a minimum percentage of meningothelial resembling cells [1]. The literature showed very rare cases of the intramedullary location of sclerosing meningiomas: in our opinion, it is mandatory to describe its clinical, surgical, histological and immunohistochemical features in order to reach the best final outcome. Sclerosing meningiomas are often misdiagnosed because of their invasive behaviour: it does require a correct diagnosis in order to prevent unnecessary postoperative treatment. Literature reports only 30 cases of sclerosing meningiomas and only 2 of them are intramedullary. We present the case of a cervical intramedullary sclerosing meningioma presenting with gait disturbances, sensory deficits, four extremities weakness and hypereflexia in a patient with the history of meningiomatosis

    Rapid copper acquisition by developing murine mesothelioma: Decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration

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    Copper, an essential trace element acquired through nutrition, is an important co-factor for pro-angiogenic factors including vascular endothelial growth factor (VEGF). Decreasing bioavailable copper has been used as an antiangiogenic and anti-cancer strategy with promising results. However, the role of copper and its potential as a therapy in mesothelioma is not yet well understood. Therefore, we monitored copper levels in progressing murine mesothelioma tumors and analyzed the effects of lowering bioavailable copper. Copper levels in tumors and organs were assayed using atomic absorption spectrophotometry. Mesothelioma tumors rapidly sequestered copper at early stages of development, the copper was then dispersed throughout growing tumor tissues. These data imply that copper uptake may play an important role in early tumor development. Lowering bioavailable copper using the copper chelators, penicillamine, trientine or tetrathiomolybdate, slowed in vivo mesothelioma growth but did not provide any cures similar to using cisplatin chemotherapy or anti-VEGF receptor antibody therapy. The impact of copper lowering on tumor blood vessels and tumor infiltrating T cells was measured using flow cytometry and confocal microscopy. Copper lowering was associated with reduced tumor vessel diameter, reduced endothelial cell proliferation (reduced Ki67 expression) and lower surface ICAM/CD54 expression implying reduced endothelial cell activation, in a process similar to endothelial normalization. Copper lowering was also associated with a CD4+ T cell infiltrate. In conclusion, these data suggest copper lowering is a potentially useful anti-mesothelioma treatment strategy that slows tumor growth to provide a window of opportunity for inclusion of other treatment modalities to improve patient outcomes

    Una procedura di stima delle varianze utilizzabile in una coerente valutazione dei flussi delle tavole intersettoriali

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    Università degli Studi di Ancona, Istituto di Matematica e Statistica Quaderno n. 7

    La performance dei modelli di previsione della volatilità

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    Nell’ambito dei mercati finanziari la volatilità è il grado con il quale le quotazioni dei titoli tendono a fluttuare nel tempo. Come tale, essa è un concetto strettamente collegato a quello di rischio. Per tale motivo, quando si valuta la opportunità di un investimento, l’analisi della previsione della volatilità rappresenta un elemento di investigazione di fondamentale importanza la quale a suscitato l’interesse degli studiosi e non in modo particolare. L’obiettivo del lavoro è quello di analizzare la capacità di prevedere la volatilità di alcuni dei modelli che più comunemente vengono utilizzati nella pratica

    Analisi della student satisfaction nella Facoltà di Economia G. Fuà di Ancona

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    Università Politecnica delle Marche, Dipartimento di Economia, Quaderni di ricerca n. 21

    Free thiols in human spermatozoa: correlation with Na+/K+-ATPase, Ca2+-ATPase activities and sperm motility

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    La struttura delle attività terziarie nelle zone omogenee e funzionali delle Marche

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    ASTAC (Centro Interuniversitario Arti Scienze e Tecnologia dell’Ambiente e del Costruire) Regione March

    Production of proxynitrite by human spermatozoa may affects sperm motility through the formation of protein nitrotyrosine

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