A self-organized resource allocation scheme for heterogeneous macro-femto networks

This paper investigates the radio resource management (RRM) issues in a heterogeneous macro-femto network. The objective of femto deployment is to improve coverage, capacity, and experienced quality of service of indoor users. The location and density of user-deployed femtos is not known a-priori. This makes interference management crucial. In particular, with co-channel allocation (to improve resource utilization efficiency), RRM becomes involved because of both cross-layer and co-layer interference. In this paper, we review the resource allocation strategies available in the literature for heterogeneous macro-femto network. Then, we propose a self-organized resource allocation (SO-RA) scheme for an orthogonal frequency division multiple access based macro-femto network to mitigate co-layer interference in the downlink transmission. We compare its performance with the existing schemes like Reuse-1, adaptive frequency reuse (AFR), and AFR with power control (one of our proposed modification to AFR approach) in terms of 10 percentile user throughput and fairness to femto users. The performance of AFR with power control scheme matches closely with Reuse-1, while the SO-RA scheme achieves improved throughput and fairness performance. SO-RA scheme ensures minimum throughput guarantee to all femto users and exhibits better performance than the existing state-of-the-art resource allocation schemes

TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue

Recent identification of active brown fat reserves in adult humans has re-stimulated interest in the role of brown adipocytes in energy homeostasis. In addition, there is accumulating evidence to support the concept of an alteration in energy balance through acquisition of brown fat features in traditional white fat depots. We recently described an important role played by the TGF-β/Smad3 signaling pathway in modulating the appearance of brown adipocytes in traditional white fat, and its implications to thermogenesis, mitochondrial energetics, energy expenditure, and protection from diabetes and obesity. Here we review the data supporting this phenomenon and put into perspective the promise of conversion of white fat to a brown fat state as a potential therapeutic option for obesity and diabetes

Experimental Investigation of the Transient Flow in Roots Blower

Rotary positive displacement machines are common method to pump flow in various process industries. Their performance highly depends on the operational clearances. It is widely believed that computational fluid dynamics (CFD) can help understanding and reducing internal leakage flows. However, Developments of grid generating tools for use of CFD in rotary positive displacement machines have not yet been fully validated. Thereby arising a need to validate these models that help in better understanding of the leakage flows. Roots blower is a good representative of positive displacement machines and as such is convenient for optical access to analyse flows in in such machines. This paper describes the setup of the experimental test rig with the optical Roots blower in the Centre for Compressor Technology at City, University of London and the first results obtained using three different flow visualization methods. These are namely i) the high-speed camera (HC), ii) the continuous time resolved PIV (CPIV) and iii) the instantaneous PIV obtained with double pulse PIV laser and double shutter camera (IPIV). Test results from these three tests are compared and discussed in the paper. The CPIV test shows the movement of the vortex and the general shape of the flow field clearly but is not sufficient to calculate velocity vectors of high-velocity particles due to the limitation of the laser and camera. The IPIV test can produce quantitative velocity vector images of the internal flow but needs improvement to look into the leakage flow. The work described in this paper is a part of the large project set to evaluate characteristics of the internal flow in rotary positive displacement machines and to characterize leakage flows. The objective is to enable further improvements in 3D CFD analysis of leakage flows in rotary positive displacement machines and ultimately lead to the improvement in the performance of rotary positive displacement machines

A rare case of zolendronate infusion complication leading to glaucoma filtration surgery

Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of Paget’s disease, osteoporosis, and hypercalcemia of malignancy. We report a rare and challenging complication of zolendronate infusion: unilateral acute anterior uveitis followed by persistently raised intraocular pressure despite being on four different classes of antiglaucoma medication. The challenge was that the patient required topical steroid to treat her uveitis in the background of known glaucoma with corresponding steroid response. She eventually underwent a left phacotrabeculectomy augmented with 5-fluorouracil. Four weeks postoperatively she developed an encapsulated bleb and underwent needling with 5-fluorouracil. This case highlights the importance of having a high index of suspicion for anterior uveitis in patients with a red and painful eye after initiating biphosphonate therapy. Caution should also be exercised when prescribing biphosponates to glaucoma patients

Characterizations of Ultrasonically Prepared Nanostructured ZnO powder and NH3 Sensing Performance of its Thick Film Sensor

AbstractIn the present investigation nanostructured ZnO powder was prepared using ultrasonic atomization method. An aqueous solution of Zn (NO3)2 *6H2O was atomised using ultrasonic atomizer. The prepared nanostructured ZnO powder was collected using a simple but novel trapping system. The powder was characterized using XRD, TEM, SEM and EDAX. Nanostructured thick-film sensors of this powder were prepared by using the simple screen printing technique. The gas sensing performance of this film was tested. The sensor was found to be most sensitive to NH3

Cdk4 Regulates Recruitment of Quiescent β-Cells and Ductal Epithelial Progenitors to Reconstitute β-Cell Mass

Insulin-producing pancreatic islet β cells (β-cells) are destroyed, severely depleted or functionally impaired in diabetes. Therefore, replacing functional β-cell mass would advance clinical diabetes management. We have previously demonstrated the importance of Cdk4 in regulating β-cell mass. Cdk4-deficient mice display β-cell hypoplasia and develop diabetes, whereas β-cell hyperplasia is observed in mice expressing an active Cdk4R24C kinase. While β-cell replication appears to be the primary mechanism responsible for β-cell mass increase, considerable evidence also supports a contribution from the pancreatic ductal epithelium in generation of new β-cells. Further, while it is believed that majority of β-cells are in a state of ‘dormancy’, it is unclear if and to what extent the quiescent cells can be coaxed to participate in the β-cell regenerative response. Here, we address these queries using a model of partial pancreatectomy (PX) in Cdk4 mutant mice. To investigate the kinetics of the regeneration process precisely, we performed DNA analog-based lineage-tracing studies followed by mathematical modeling. Within a week after PX, we observed considerable proliferation of islet β-cells and ductal epithelial cells. Interestingly, the mathematical model showed that recruitment of quiescent cells into the active cell cycle promotes β-cell mass reconstitution in the Cdk4R24C pancreas. Moreover, within 24–48 hours post-PX, ductal epithelial cells expressing the transcription factor Pdx-1 dramatically increased. We also detected insulin-positive cells in the ductal epithelium along with a significant increase of islet-like cell clusters in the Cdk4R24C pancreas. We conclude that Cdk4 not only promotes β-cell replication, but also facilitates the activation of β-cell progenitors in the ductal epithelium. In addition, we show that Cdk4 controls β-cell mass by recruiting quiescent cells to enter the cell cycle. Comparing the contribution of cell proliferation and islet-like clusters to the total increase in insulin-positive cells suggests a hitherto uncharacterized large non-proliferative contribution

Binuclear Manganese(III) Complexes as Electron Donors in D1/D2/Cytochrome b559 Preparations Isolated from Spinach Photosystem II Membrane Fragments

The capability of different manganese complexes to act as PS II electron donors in D1/D2/ cytochrome b 559 complexes has been analyzed by measuring actinic light-induced absorption changes at 680 nm (650 nm) and 340 nm, reflecting the photoaccumulation of Pheophytin- (Pheo-) and the reduction of NADP+ respectively. The data obtained reveal: a) the donor capacity of synthetic binuclear Mn(III)2 complexes containing aromatic ligands significantly exceeds that for MnCl2 in both cases, i.e. Pheo- photoaccumulation and NADP+ reduction; b) manganese complexes can serve as suitable electron donors for light-induced NADP+ reduction catalyzed by D1/D2/cytochrome b559 complexes and ferredoxin plus ferredoxin- NADP+ reductase under anaerobic conditions and c) the specific turnover rate of the system leading to NADP+ reduction is extremely small. The implications of these findings are briefly discussed