The Effect of Endurance Training on Pulmonary V˙O2 Kinetics in Solid Organs Transplanted Recipients

BACKGROUND: We investigated the effects of single (SL-ET) and double leg (DL-ET) high-intensity interval training on O2 deficit (O2Def) and mean response time (MRT) during square-wave moderate-intensity exercise (DL-MOD), and on the amplitude of V˙O2p slow component (SCamp), during heavy intensity exercise (DL-HVY), on 33 patients (heart transplant = 13, kidney transplanted = 11 and liver transplanted = 9). METHODS: Patients performed DL incremental step exercise to exhaustion, two DL-MOD tests, and a DL-HVY trial before and after 24 sessions of SL-ET (n = 17) or DL-ET (n = 16). RESULTS: After SL-ET, O2Def, MRT and SCamp decreased by 16.4% ± 13.7 (p = 0.008), by 15.6% ± 13.7 (p = 0.004) and by 35% ± 31 (p = 0.002), respectively. After DL-ET, they dropped by 24.9% ± 16.2 (p < 0.0001), by 25.9% ± 13.6 (p < 0.0001) and by 38% ± 52 (p = 0.0003), respectively. The magnitude of improvement of O2Def, MRT, and SCamp was not significantly different between SL-ET and DL-ET after training. CONCLUSIONS: We conclude that SL-ET is as effective as DL-ET if we aim to improve V˙O2p kinetics in transplanted patients and suggest that the slower, V˙O2p kinetics is mainly caused by the impairment of peripherals exchanges likely due to the immunosuppressive medications and disuse

Association between the donor to recipient ICG-PDR variation rate and the functional recovery of the graft after orthotopic liver transplantation: A case series

Background: Despite current advances in liver transplant surgery, post-operative early allograft dysfunction still complicates the patient prognosis and graft survival. The transition from the donor has not been yet fully understood, and no study quantifies if and how the liver function changes through its transfer to the recipient. The indocyanine green dye plasma disappearance rate (ICG-PDR) is a simple validated tool of liver function assessment. The variation rate between the donor and recipient ICG-PDR still needs to be investigated. Materials and methods: Single-center retrospective study. ICG-PDR determinations were performed before graft retrieval (T1) and 24 hours after transplant (T2). The ICG-PDR relative variation rate between T1 and T2 was calculated to assess the graft function and suffering/recovering. Matched data were compared with the MEAF model of graft dysfunction. Objective: To investigate whether the variation rate between the donor ICG-PDR value and the recipient ICG-PDR measurement on first postoperative day (POD1) can be associated with the MEAF score. Results: 36 ICG-PDR measurements between 18 donors and 18 graft recipients were performed. The mean donor ICG-PDR was 22.64 (SD 6.35), and the mean receiver's ICG-PDR on 1st POD was 17.68 (SD 6.60), with a mean MEAF value of 4.51 (SD 1.23). Pearson's test stressed a good, linear inverse correlation between the ICG-PDR relative variation and the MEAF values, correlation coefficient -0.580 (p = 0.012). Conclusion: The direct correlation between the donor to recipient ICG-PDR variation rate and MEAF was found. Measurements at T1 and T2 showed an up- or downtrend of the graft performance that reflect the MEAF values

Signatures for Majorana neutrinos in e−γe^- \gamma collider

We study the possibilities to detect Majorana neutrinos in $e^- \gamma$ colliders for different center of mass energies. We study the $W^- W^- l_j^{+}(l_j^+\equiv e^+ ,\mu^+ ,\tau^+)$ final state which are, due to leptonic number violation, a clear signature for intermediate Majorana neutrino contribution. Such a signal (final lepton have the opposite charge of the initial lepton) is not possible if the heavy neutrinos are Dirac particles. In our calculation we use the helicity formalism to obtain analytic expressions for the amplitude and we have considered that the intermediate neutrinos can be either on shell or off shell. Finally we present our results for the total cross-section and for the angular distribution of the final lepton. We also include a discussion on the expected events number as a function of the input parameters.Comment: Latex file with 12 pages and 6 figures. Submited to Phys. Rev.

Signatures of Right-Handed Majorana neutrinos and gauge bosons in eγe \gamma Collisions

The process $e^- \gamma \to e^+ W_R^- W_R^-$ is studied in the framework of the Left-Right symmetric model. It is shown that this reaction and $e^- \gamma \to l^+ W_R^- W_R^-$ for the arbitrary final lepton are likely to be discovered for CLIC collider option. For relatively light doubly charged Higgs boson its mass does not have much influence on the discovery potential, while for heavier values the probability of the reaction increases.Comment: 18 pages, 7 figures, LaTe

Nota sulla storia del Vat. Lat. 3195

Il saggio affronta la storia di un manoscritto celebre, l’originale in parte autografo del libro lirico forse più importante della storia d’Europa. Molte tappe di questa storia erano venute alla luce da studi archivistici del ‘900. Altre erano ignote. Anche la storia della biblioteca del Petrarca , nell’atto della sua dispersione non è stata scritta. Il saggio si propone di ricostruire questa storia sino al ‘900, illuminandone alcuni aspetti ignoti, a cominciare da quando questo manoscritto era sullo scrittoio del Petrarca per gli ultimi ritocchi. Si dimostra che allora il manoscritto fu dato a copiare ad amanuensi per copie privilegiate. E che prima che Petrarca finisse di mettervi l’ultima mano, queste copie uscirono dal suo scrittoio e una arrivò nel circolo degli allievi fiorentini vicino al Salutati. Aprono nuove vie di ricerca su questo punto i sondaggi sui primi codici trecenteschi ed in particolare sul codice Laur. XLI, 10. Quanto alla fortuna del testo un esempio curioso della vicenda quattrocentesca è ricavato dal codice Montpellier, Faculté de Medicine H 198, fatto allestire da Federico di Montefeltro e da i suoi rapporti con il primo incunabolo padovano che ne trasse copia, l’edizione stampata da Bartolomeo Valdezoco (curata in anastatica dall’autore del saggio