Construct validity of the Experiences of Therapy Questionnaire (ETQ)

ObjectiveThe Experiences of Therapy Questionnaire (ETQ) is a reliable measure of adverse effects associated with psychotherapy. The measure has not been subject to validity analyses. This study sought to examine the validity of the ETQ by comparison against a measure of therapist satisfaction.MethodsParticipants were recruited from the Black Dog Institute¿s website and completed all measures online, at two time points (two weeks apart). Correlational analyses compared scale scores on the ETQ with related constructs of the Therapist Satisfaction Scale (TSS). To exclude any impact of current depression on ratings, we examined correlations between salient ETQ and TSS scales after controlling for depression severity.ResultsForty-six participants completed all the measures at both time points. Hypothesised associations between the ETQ and TSS scales were supported, irrespective of current depression severity.ConclusionsThe validity of the ETQ is supported; however limitations of the study are noted, including generalizability due to sample characteristics

Polarized Diffuse Emission at 2.3 GHz in a High Galactic Latitude Area

Polarized diffuse emission observations at 2.3 GHz in a high Galactic latitude area are presented. The 2\degr X 2\degr field, centred in (\alpha=5^h,\delta=-49\degr), is located in the region observed by the BOOMERanG experiment. Our observations has been carried out with the Parkes Radio telescope and represent the highest frequency detection done to date in low emission areas. Because of a weaker Faraday rotation action, the high frequency allows an estimate of the Galactic synchrotron contamination of the Cosmic Microwave Background Polarization (CMBP) that is more reliable than that done at 1.4 GHz. We find that the angular power spectra of the E- and B-modes have slopes of \beta_E = -1.46 +/- 0.14 and \beta_B = -1.87 +/- 0.22, indicating a flattening with respect to 1.4 GHz. Extrapolated up to 32 GHz, the E-mode spectrum is about 3 orders of magnitude lower than that of the CMBP, allowing a clean detection even at this frequency. The best improvement concerns the B-mode, for which our single-dish observations provide the first estimate of the contamination on angular scales close to the CMBP peak (about 2 degrees). We find that the CMBP B-mode should be stronger than synchrotron contamination at 90 GHz for models with T/S > 0.01. This low level could move down to 60-70 GHz the optimal window for CMBP measures.Comment: 5 pages, 6 figures, accepted for publication in MNRAS Letter

GSH23.0-0.7+117, a neutral hydrogen shell in the inner Galaxy

GSH23.0-0.7+117 is a well-defined neutral hydrogen shell discovered in the VLA Galactic Plane Survey (VGPS). Only the blueshifted side of the shell was detected. The expansion velocity and systemic velocity were determined through the systematic behavior of the HI emission with velocity. The center of the shell is at (l,b,v)=(23.05,-0.77,+117 km/s). The angular radius of the shell is 6.8', or 15 pc at a distance of 7.8 kpc. The HI mass divided by the volume of the half-shell implies an average density n_H = 11 +/- 4 cm^{-3} for the medium in which the shell expanded. The estimated age of GSH23.0-0.7+117 is 1 Myr, with an upper limit of 2 Myr. The modest expansion energy of 2 * 10^{48} erg can be provided by the stellar wind of a single O4 to O8 star over the age of the shell. The 3 sigma upper limit to the 1.4 GHz continuum flux density (S_{1.4} < 248 mJy) is used to derive an upper limit to the Lyman continuum luminosity generated inside the shell. This upper limit implies a maximum of one O9 star (O8 to O9.5 taking into account the error in the distance) inside the HI shell, unless most of the incident ionizing flux leaks through the HI shell. To allow this, the shell should be fragmented on scales smaller than the beam (2.3 pc). If the stellar wind bubble is not adiabatic, or the bubble has burst (as suggested by the HI channel maps), agreement between the energy and ionization requirements is even less likely. The limit set by the non-detection in the continuum provides a significant challenge for the interpretation of GSH23.0-0.7+117 as a stellar wind bubble. A similar analysis may be applicable to other Galactic HI shells that have not been detected in the continuum.Comment: 18 pages, 6 figures. Figures 1 and 4 separately in GIF format. Accepted for publication in Astrophysical Journa

Shot Noise in Graphene

We report measurements of current noise in single- and multi-layer graphene devices. In four single-layer devices, including a p-n junction, the Fano factor remains constant to within +/-10% upon varying carrier type and density, and averages between 0.35 and 0.38. The Fano factor in a multi-layer device is found to decrease from a maximal value of 0.33 at the charge-neutrality point to 0.25 at high carrier density. These results are compared to theoretical predictions for shot noise in ballistic and disordered graphene.Comment: related papers available at http://marcuslab.harvard.ed

The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD

Objective The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). Methods 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34+/KDR+ cells. Results Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. Conclusions Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis

Shot-Noise Signatures of 0.7 Structure and Spin in a Quantum Point Contact

We report simultaneous measurement of shot noise and dc transport in a quantum point contact as a function of source-drain bias, gate voltage, and in-plane magnetic field. Shot noise at zero field exhibits an asymmetry related to the 0.7 structure in conductance. The asymmetry in noise evolves smoothly into the symmetric signature of spin-resolved electron transmission at high field. Comparison to a phenomenological model with density-dependent level splitting yields good quantitative agreement.Comment: related papers at http://marcuslab.harvard.ed

Polarization Gradient Study of Interstellar Medium Turbulence Using The Canadian Galactic Plane Survey

We have investigated the magneto-ionic turbulence in the interstellar medium through spatial gradients of the complex radio polarization vector in the Canadian Galactic Plane Survey (CGPS). The CGPS data cover 1300 square-degrees, over the range ${53^{\circ}}\leq{\ell}\leq{192^{\circ}}$, ${-3^{\circ}}\leq{b}\leq{5^{\circ}}$ with an extension to ${b}={17.5^{\circ}}$ in the range ${101^{\circ}}\leq{\ell}\leq{116^{\circ}}$, and arcminute resolution at 1420 MHz. Previous studies found a correlation between the skewness and kurtosis of the polarization gradient and the Mach number of the turbulence, or assumed this correlation to deduce the Mach number of an observed turbulent region. We present polarization gradient images of the entire CGPS dataset, and analyze the dependence of these images on angular resolution. The polarization gradients are filamentary, and the length of these filaments is largest towards the Galactic anti-center, and smallest towards the inner Galaxy. This may imply that small-scale turbulence is stronger in the inner Galaxy, or that we observe more distant features at low Galactic longitudes. For every resolution studied, the skewness of the polarization gradient is influenced by the edges of bright polarization gradient regions, which are not related to the turbulence revealed by the polarization gradients. We also find that the skewness of the polarization gradient is sensitive to the size of the box used to calculate the skewness, but insensitive to Galactic longitude, implying that the skewness only probes the number and magnitude of the inhomogeneities within the box. We conclude that the skewness and kurtosis of the polarization gradient are not ideal statistics for probing natural magneto-ionic turbulence.Comment: 21 pages, 15 figures, accepted by Ap

Adaptations of an RNA virus to increasing thermal stress

Environments can change in incremental fashions, where a shift from one state to another occurs over multiple organismal generations. The rate of the environmental change is expected to influence how and how well populations adapt to the final environmental state. We used a model system, the lytic RNA bacteriophage Φ6, to investigate this question empirically. We evolved viruses for thermostability by exposing them to heat shocks that increased to a maximum temperature at different rates. We observed increases in the ability of many heat-shocked populations to survive high temperature heat shocks. On their first exposure to the highest temperature, populations that experienced a gradual increase in temperature had higher average survival than populations that experienced a rapid temperature increase. However, at the end of the experiment, neither the survival of populations at the highest temperature nor the number of mutations per population varied significantly according to the rate of thermal change. We also evaluated mutations from the endpoint populations for their effects on viral thermostability and growth. As expected, some mutations did increase viral thermostability. However, other mutations decreased thermostability but increased growth rate, suggesting that benefits of an increased replication rate may have sometimes outweighed the benefits of enhanced thermostability. Our study highlights the importance of considering the effects of multiple selective pressures, even in environments where a single factor changes