27,390 research outputs found
Thermochromism of Model Organic Aerosol Matter
Laboratory experiments show that the optical absorptivity of model organic matter is not an intrinsic property, but a strong function of relative humidity, temperature, and insolation. Suites of representative polyfunctional C_(x)H_(y)O_(z) oligomers in water develop intense visible absorptions upon addition of inert electrolytes. The resulting mixtures reach mass absorption cross sections σ(532 nm) ~ 0.1 m^(2)/gC in a few hours, absorb up to 9 times more solar radiation than the starting material, can be half-bleached by noon sunlight in ~ 1 h, and can be repeatedly recycled without carbon loss. Visible absorptions red-shift and evolve increasingly faster in subsequent thermal aging cycles. Thermochromism and its strong direct dependences on ionic strength and temperature are ascribed to the dehydration of >CH−C(OH)C═C< unsaturations by a polar E1 mechanism, and bleaching to photoinduced retrohydration. These transformations are deemed to underlie the daily cycles of aerosol absorption observed in the field, and may introduce a key feedback in the earth’s radiative balance
Spectral properties and geology of bright and dark material on dwarf planet Ceres
Variations and spatial distributions of bright and dark material on dwarf
planet Ceres play a key role in understanding the processes that have led to
its present surface composition. We define limits for bright and dark material
in order to distinguish them consistently, based on the reflectance of the
average surface using Dawn Framing Camera data. A systematic classification of
four types of bright material is presented based on their spectral properties,
composition, spatial distribution, and association with specific
geomorphological features. We found obvious correlations of reflectance with
spectral shape (slopes) and age; however, this is not unique throughout the
bright spots. Although impact features show generally more extreme reflectance
variations, several areas can only be understood in terms of inhomogeneous
distribution of composition as inferred from Dawn Visible and Infrared
Spectrometer data. Additional material with anomalous composition and spectral
properties are rare. The identification of the composition and origin of the
dark, particularly the darkest material, remains to be explored. The spectral
properties and the morphology of the dark sites suggest an endogenic origin,
but it is not clear whether they are more or less primitive surficial exposures
or excavated subsurface but localized material. The reflectance, spectral
properties, inferred composition, and geologic context collectively suggest
that the bright and dark material tends to gradually change toward the average
surface over time. This could be because of multiple processes, i.e., impact
gardening/space weathering, and lateral mixing, including thermal and aqueous
alteration, accompanied by changes in composition and physical properties such
as grain size, surface temperature, and porosity (compaction).Comment: Meteoritics and Planetary Science; Dawn at Ceres special issu
KWISP: an ultra-sensitive force sensor for the Dark Energy sector
An ultra-sensitive opto-mechanical force sensor has been built and tested in
the optics laboratory at INFN Trieste. Its application to experiments in the
Dark Energy sector, such as those for Chameleon-type WISPs, is particularly
attractive, as it enables a search for their direct coupling to matter. We
present here the main characteristics and the absolute force calibration of the
KWISP (Kinetic WISP detection) sensor. It is based on a thin Si3N4
micro-membrane placed inside a Fabry-Perot optical cavity. By monitoring the
cavity characteristic frequencies it is possible to detect the tiny membrane
displacements caused by an applied force. Far from the mechanical resonant
frequency of the membrane, the measured force sensitivity is 5.0e-14
N/sqrt(Hz), corresponding to a displacement sensitivity of 2.5e-15 m/sqrt(Hz),
while near resonance the sensitivity is 1.5e-14 N/sqrt(Hz), reaching the
estimated thermal limit, or, in terms of displacement, 7.5e-16 N/sqrt(Hz).
These displacement sensitivities are comparable to those that can be achieved
by large interferometric gravitational wave detectors.Comment: 9 pages, 8 figures in colo
A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.
Background and aims: The transcription factor nuclear
factor kappa B (NF-kB) has risen as a promising target for
anti-inflammatory therapeutics. In the liver, however, NFkB
inhibition mediates both damaging and protective
effects. The outcome is deemed to depend on the liver
cell type addressed. Recent gene knock-out studies
focused on the role of NF-kB in hepatocytes, whereas the
role of NF-kB in Kupffer cells has not yet been
investigated in vivo. Here we present a novel approach,
which may be suitable for clinical application, to
selectively target NF-kB in Kupffer cells and analyse the
effects in experimental models of liver injury.
Methods: NF-kB inhibiting decoy oligodeoxynucleotides
were loaded upon gelatin nanoparticles (D-NPs) and their
in vivo distribution was determined by confocal microscopy.
Liver damage, NF-kB activity, cytokine levels and
apoptotic protein expression were evaluated after
lipopolysaccharide (LPS), D-galactosamine (GalN)/LPS, or
concanavalin A (ConA) challenge and partial warm
ischaemia and subsequent reperfusion, respectively.
Results: D-NPs were selectively taken up by Kupffer cells
and inhibited NF-kB activation. Inhibition of NF-kB in
Kupffer cells improved survival and reduced liver injury
after GalN/LPS as well as after ConA challenge. While
anti-apoptotic protein expression in liver tissue was not
reduced, pro-apoptotic players such as cJun N-terminal
kinase (JNK) were inhibited. In contrast, selective
inhibition of NF-kB augmented reperfusion injury.
Conclusions: NF-kB inhibiting decoy oligodeoxynucleotide-
loaded gelatin nanoparticles is a novel tool to
selectively inhibit NF-kB activation in Kupffer cells in vivo.
Thus, liver injury can be reduced in experimental fulminant
hepatitis, but increased at ischaemia–reperfusion
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