Microcantilever Studies of Angular Field Dependence of Vortex Dynamics in BSCCO

Using a nanogram-sized single crystal of BSCCO attached to a microcantilever we demonstrate in a direct way that in magnetic fields nearly parallel to the {\it ab} plane the magnetic field penetrates the sample in the form of Josephson vortices rather than in the form of a tilted vortex lattice. We further investigate the relation between the Josephson vortices and the pancake vortices generated by the perpendicular field component.Comment: 5 pages, 8 figure

Investigating The Vortex Melting Phenomenon In BSCCO Crystals Using Magneto-Optical Imaging Technique

Using a novel differential magneto-optical imaging technique we investigate the phenomenon of vortex lattice melting in crystals of Bi_2Sr_2CaCu_2O_8 (BSCCO). The images of melting reveal complex patterns in the formation and evolution of the vortex solid-liquid interface with varying field (H) or temperature (T). We believe that the complex melting patterns are due to a random distribution of material disorder or inhomogeneities across the sample, which create fluctuations in the local melting temperature or field value. To study the fluctuations in the local melting temperature / field, we have constructed maps of the melting landscape T_m(H,r), viz., the melting temperature (T_m) at a given location (r) in the sample at a given field (H). A study of these melting landscapes reveals an unexpected feature: the melting landscape is not fixed, but changes rather dramatically with varying field and temperature along the melting line. It is concluded that the changes in both the scale and shape of the landscape result from the competing contributions of different types of quenched disorder which have opposite effects on the local melting transition.Comment: Paper presented at the International Symposium on Advances in Superconductivity & Magnetism: Materials, Mechanisms & Devices September 25-28, 2001, Mangalore, India. Symposium proceedings will be published in a special issue of Pramana - Journal of Physic

The London theory of the crossing-vortex lattice in highly anisotropic layered superconductors

A novel description of Josephson vortices (JVs) crossed by the pancake vortices (PVs) is proposed on the basis of the anisotropic London theory. The field distribution of a JV and its energy have been calculated for both dense ($a\lambda_J$) PV lattices with distance $a$ between PVs, and the nonlinear JV core size $\lambda_J$. It is shown that the ``shifted'' PV lattice (PVs displaced mainly along JVs in the crossing vortex lattice structure), formed in high out-of-plane magnetic fields transforms into the PV lattice ``trapped'' by the JV sublattice at a certain field, lower than $\Phi_0/\gamma^2s^2$, where $\Phi_0$ is the flux quantum, $\gamma$ is the anisotropy parameter and $s$ is the distance between CuO$_2$ planes. With further decreasing $B_z$, the free energy of the crossing vortex lattice structure (PV and JV sublattices coexist separately) can exceed the free energy of the tilted lattice (common PV-JV vortex structure) in the case of $\gamma s<\lambda_{ab}$ with the in-plane penetration depth $\lambda_{ab}$ if the low ($B_x<\gamma\Phi_0/\lambda_{ab}^2$) or high ($B_x\gtrsim \Phi_0/\gamma s^2$) in-plane magnetic field is applied. It means that the crossing vortex structure is realized in the intermediate field orientations, while the tilted vortex lattice can exist if the magnetic field is aligned near the $c$-axis and the $ab$-plane as well. In the intermediate in-plane fields $\gamma\Phi_0/\lambda_{ab}^2\lesssim B_x \lesssim \Phi_0/\gamma s^2$, the crossing vortex structure with the ``trapped'' PV sublattice seems to settle in until the lock-in transition occurs since this structure has the lower energy with respect to the tilted vortex structure in the magnetic field ${\vec H}$ oriented near the $ab$-plane.Comment: 15 pages, 6 figures, accepted for publication in PR

Evolution of deformation and breakage in sand studied using X-ray tomography

International audienceParticle breakage of a granular material can cause significant changes in its microstructure, which will govern its macroscopic behaviour; this explains why the mechanisms leading to particle breakage have been a common subject within several fields, including geomechanics. In this paper, X-ray computed micro-tomography is used, to obtain three-dimensional images of entire specimens of sand, during high-confinement triaxial compression tests. The acquired images are processed and measurements are made on breakage, local variations of porosity, volumetric strain, maximum shear strain and grading. The evolution and spatial distribution of quantified breakage and the resulting particle size distribution for the whole specimen and for specific areas are presented here for the first time and are further related to the localised shear and volumetric strains. Before peak stress is reached, compaction is the governing mechanism leading to breakage; neither compressive strains nor breakage are significantly localised and the total amount of breakage is rather low. Post peak, in areas where strains localise and breakage is present, a dilative volumetric behaviour is observed locally, as opposed to the overall compaction of the specimen. Some specimens exhibited a compaction around the shear band at the end of the test, but there was no additional breakage at that point. From the grading analysis, it is found that mainly the grains with diameter close to the mean diameter of the specimen are the ones that break, whereas the biggest grains that are present in the specimen remain intact

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. Further analysis of miRNAs concomitantly regulated by knockdown of the NRF2 inhibitor KEAP1 revealed the major candidate NRF2-mediated miRNAs in AML. We identified miR-125B to be upregulated and miR-29B to be downregulated by NRF2 in AML. Subsequent bioinformatic analysis identified putative NRF2 binding sites upstream of the miR-125B1 coding region and downstream of the mir-29B1 coding region. Chromatin immunoprecipitation analyses showed that NRF2 binds to these antioxidant response elements (AREs) located in the 5′ untranslated regions of miR-125B and miR-29B. Finally, primary AML samples transfected with anti-miR-125B antagomiR or miR-29B mimic showed increased cell death responsiveness either alone or co-treated with standard AML chemotherapy. In summary, we find that NRF2 regulation of miR-125B and miR-29B acts to promote leukaemic cell survival, and their manipulation enhances AML responsiveness towards cytotoxic chemotherapeutics

Tuning the graphene work function by electric field effect

We report variation of the work function for single and bi-layer graphene devices measured by scanning Kelvin probe microscopy (SKPM). Using the electric field effect, the work function of graphene can be adjusted as the gate voltage tunes the Fermi level across the charge neutrality point. Upon biasing the device, the surface potential map obtained by SKPM provides a reliable way to measure the contact resistance of individual electrodes contacting graphene.Comment: 11 pages and 8 figures including supplementary information, to appear in Nano Letter

Experiments in vortex avalanches

Avalanche dynamics is found in many phenomena spanning from earthquakes to the evolution of species. It can be also found in vortex matter when a type II superconductor is externally driven, for example, by increasing the magnetic field. Vortex avalanches associated with thermal instabilities can be an undesirable effect for applications, but "dynamically driven" avalanches emerging from the competition between intervortex interactions and quenched disorder constitute an interesting scenario to test theoretical ideas related with non-equilibrium dynamics. However, differently from the equilibrium phases of vortex matter in type II superconductors, the study of the corresponding dynamical phases - in which avalanches can play a role - is still in its infancy. In this paper we critically review relevant experiments performed in the last decade or so, emphasizing the ability of different experimental techniques to establish the nature and statistical properties of the observed avalanche behavior.Comment: To be published in Reviews of Modern Physics April 2004. 17 page