Forages for Horses Programmes

A survey by the American Horse Council in 1996 showed there were 6.9 million horses in the USA with 1.9 million horse owners and 7.1 million people involved in allied industries. The value of the USA horse industry to the gross national product is $25.3 billion. Nationally, 2.2$776 million per year. Most of the 48,500 homes with horses in Ohio have 2-5 horses with 1-2 ha of land. Many exercise lots and high-use areas are little more than mud lots. Since each horse needs a minimum of 0.8 ha for feed, many pastures and hay fields are over-grazed and poorly managed leading to soil erosion, nutrient management problems with excess manure, and water quality problems. Most horse owners have a need for basic education to help them make good decisions on pasture and horse management. The educational resources directed at the 263,500 Ohioans involved in the horse industry are minor compared to its size. The objectives of the Ohio Horse Program are: 1) To increase awareness, knowledge and skills for horse owners on managing hay fields and pastures to produce quality horse forages, 2) To change management practices of horse owners to produce higher quality forages by learning how to better evaluate, produce, store and manage quality forages, 3) To develop a curriculum and provide a notebook of indexed referenced material to all programme participants, 4) To establish a grass plot programme to compare forage varieties for yield and quality, and 5) To provide field day and pasture walk experiences

Daily associations between cannabis use and alcohol use among people who use cannabis for both medicinal and nonmedicinal reasons: Substitution or complementarity?

Objective: People who use cannabis for medicinal (versus nonmedicinal) reasons report greater cannabis use and lower alcohol use, which may reflect a cannabis–alcohol substitution effect in this population. However, it is unclear whether cannabis is used as a substitute or complement to alcohol at the day level among people who use cannabis for both medicinal and nonmedicinal reasons. This study used ecological momentary assessment (EMA) to examine this question. Method: Participants (N = 66; 53.1% men; mean age 33 years) completed daily surveys assessing previous-day reasons for cannabis use (medicinal versus nonmedicinal), cannabis consumption (both number of different types of cannabis used and grams of cannabis flower used), and number of standard drinks consumed. Results: Multilevel models revealed that, in general, greater cannabis consumption on a given day was associated with greater same-day alcohol use. Further, days during which cannabis was used for medicinal (versus exclusively nonmedicinal) reasons were associated with reduced consumption of both cannabis and alcohol. Finally, the day-level association between medicinal reasons for cannabis use and lower alcohol consumption was mediated by using fewer grams of cannabis on medicinal cannabis use days. Conclusions: Day-level cannabis-alcohol associations may be complementary rather than substitutive among people who use cannabis for both medicinal and nonmedicinal reasons, and lower (rather than greater) cannabis consumption on medicinal use days may explain the link between medicinal reasons for cannabis use and reduced alcohol use. Still, these individuals may use greater amounts of both cannabis and alcohol when using cannabis for exclusively nonmedicinal reasons.This research was supported by grants from the Canadian Institutes of Health Research Canadian HIV Trials Network (CTN PT037; PIs: Jeffrey D. Wardell and Sergio Rueda) and from the Canadian Institutes of Health Research (159754; PIs: Jeffrey D. Wardell and Christian S. Hendershot). The views expressed herein do not necessarily represent the official policy of the Canadian Institutes of Health Research. Sergio Rueda holds an Innovator Award from the Ontario HIV Treatment Network

Forages for Horses Revamped

The Forages for Horses program began in Ohio in1998 as a collaboration between the Ohio Forages & Grasslands Council and Ohio State University Extension. Over time, additional collaborations with the Natural Resources Conservation Service, Ohio Department of Agriculture and local Soil and Water Conservation Districts expanded the program. At its inception, one to three educators would partner to provide eight hours of in-person lectures followed by a pasture walk to better the management practices of equine enthusiasts. From 2021 through 2022, the curriculum was adapted for a hybrid classroom and included three 90-minute live webinars featuring nine different presentations followed by online social events. The modifications to the curriculum were made to improve access to equine resources and grazing education across Ohio. The Forages for Horses resources were also updated as part of the process. Learning modules posted in Canvas (an online learning management system) provided additional information that expanded upon the original curriculum. In 2022, 41 students from Ohio and surrounding states registered for the online course and webinars. Participants were able to hear directly from educators - more than in past iterations of the program– to expand their depth of knowledge and increase opportunities for participation without the location of the class posing a barrier for attendance. This program will continue to be revised over the coming years to remain relevant and accessible to Ohioans

Locomotor adaptability in persons with unilateral transtibial amputation

Background Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. Objective Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). Methods The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds. In the split condition, participants walked for 15 minutes with the respective belts moving at 0.5 m/s and 1.5 m/s. Temporal spatial symmetry measures were used to evaluate reactive accommodations to the perturbation, and the adaptive/de-adaptive response. Results Persons with TTA and the reference group of persons without amputation both demonstrated highly symmetric walking at baseline. During the split adaptation and tied post-adaptation walking both groups responded with the expected reactive accommodations. Likewise, adaptive and de-adaptive responses were observed. The magnitude and rate of change in the adaptive and de-adaptive responses were similar for persons with TTA and those without an amputation. Furthermore, adaptability was no different based on belt assignment for the prosthetic limb during split adaptation walking. Conclusions Reactive changes and locomotor adaptation in response to a challenging and novel walking condition were similar in persons with TTA to those without an amputation. Results suggest persons with TTA have the capacity to modify locomotor strategies to meet the demands of most walking conditions despite challenges imposed by an amputation and use of a prosthetic limb

Ohio Pastures for Profit Online

The Pastures for Profit program is an established course created through a collaboration between Ohio State University Extension, Central State University, USDA-Natural Resources Conservation Service, Ohio Federation of Soil and Water Conservation Districts, Ohio Department of Agriculture, and the Ohio Forage and Grasslands Council. In 2021, due to COVID-19, the Pastures for Profit curriculum was adapted to a virtual classroom setting and was offered again in 2022. The virtual experience consisted of three live webinars pairing with corresponding modules in Scarlet Canvas. Enrolled students were also mailed traditional course materials for personal use. Module content was newly developed and compiled to compliment the traditional materials and included videos, quizzes, additional presentations, and technical resources. The course materials were organized and taught by a team of over 50 collaborators. During the three live webinars, nearly 20 speakers presented on topics including the basics of grazing, plant and animal science, and grazing plans. A total of 168 people enrolled in Scarlet Canvas in the two-year time frame from over 15 states and included producers, educators, technical service providers, and government agency staff. Each live session was recorded and made available to the class for access at their convenience. Those who completed the course obtained a signed certificate of completion. This platform allowed for an expanded audience reach than in the past

Retargeted adenoviruses for radiation-guided gene delivery

The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells. We isolated the GIRLRG peptide that binds to radiation-inducible 78 kDa glucose-regulated protein (GRP78), which is overexpressed on the plasma membranes of irradiated cancer cells and tumor-associated microvascular endothelial cells. The goal of our study was to improve tumor-specific adenovirus-mediated gene delivery by selectively targeting the adenovirus binding to this radiation-inducible protein. We employed an adenoviral fiber replacement approach to conduct a study of the targeting utility of GRP78-binding peptide. We have developed fiber-modified adenoviruses encoding the GRP78-binding peptide inserted into the fiber-fibritin. We have evaluated the reporter gene expression of fiber-modified adenoviruses in vitro using a panel of glioma cells and a human D54MG tumor xenograft model. The obtained results demonstrated that employment of the GRP78-binding peptide resulted in increased gene expression in irradiated tumors following infection with fiber-modified adenoviruses, compared with untreated tumor cells. These studies demonstrate the feasibility of adenoviral retargeting using the GRP78-binding peptide that selectively recognizes tumor cells responding to radiation treatment

Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry

Abstract With improved survivorship in medulloblastoma, there has been an increasing incidence of late complications. To date, no studies have specifically addressed the risk of radiation-associated diffuse intrinsic pontine glioma (DIPG) in medulloblastoma survivors. Query of the International DIPG Registry identified six cases of DIPG with a history of medulloblastoma treated with radiotherapy. All patients underwent central radiologic review that confirmed a diagnosis of DIPG. Six additional cases were identified in reports from recent cooperative group medulloblastoma trials (total n = 12; ages 7 to 21 years). From these cases, molecular subgrouping of primary medulloblastomas with available tissue (n = 5) revealed only non-WNT, non-SHH subgroups (group 3 or 4). The estimated cumulative incidence of DIPG after post-treatment medulloblastoma ranged from 0.3–3.9%. Posterior fossa radiation exposure (including brainstem) was greater than 53.0 Gy in all cases with available details. Tumor/germline exome sequencing of three radiation-associated DIPGs revealed an H3 wild-type status and mutational signature distinct from primary DIPG with evidence of radiation-induced DNA damage. Mutations identified in the radiation-associated DIPGs had significant molecular overlap with recurrent drivers of adult glioblastoma (e.g. NRAS, EGFR, and PTEN), as opposed to epigenetic dysregulation in H3-driven primary DIPGs. Patients with radiation-associated DIPG had a significantly worse median overall survival (median 8 months; range 4–17 months) compared to patients with primary DIPG. Here, it is demonstrated that DIPG occurs as a not infrequent complication of radiation therapy in survivors of pediatric medulloblastoma and that radiation-associated DIPGs may present as a poorly-prognostic distinct molecular subgroup of H3 wild-type DIPG. Given the abysmal survival of these cases, these findings provide a compelling argument for efforts to reduce exposure of the brainstem in the treatment of medulloblastoma. Additionally, patients with radiation-associated DIPG may benefit from future therapies targeted to the molecular features of adult glioblastoma rather than primary DIPG.https://deepblue.lib.umich.edu/bitstream/2027.42/145180/1/40478_2018_Article_570.pd

Relapse prevention for addictive behaviors

The Relapse Prevention (RP) model has been a mainstay of addictions theory and treatment since its introduction three decades ago. This paper provides an overview and update of RP for addictive behaviors with a focus on developments over the last decade (2000-2010). Major treatment outcome studies and meta-analyses are summarized, as are selected empirical findings relevant to the tenets of the RP model. Notable advances in RP in the last decade include the introduction of a reformulated cognitive-behavioral model of relapse, the application of advanced statistical methods to model relapse in large randomized trials, and the development of mindfulness-based relapse prevention. We also review the emergent literature on genetic correlates of relapse following pharmacological and behavioral treatments. The continued influence of RP is evidenced by its integration in most cognitive-behavioral substance use interventions. However, the tendency to subsume RP within other treatment modalities has posed a barrier to systematic evaluation of the RP model. Overall, RP remains an influential cognitive-behavioral framework that can inform both theoretical and clinical approaches to understanding and facilitating behavior change