Energy-Efficient Streaming Using Non-volatile Memory

The disk and the DRAM in a typical mobile system consume a significant fraction (up to 30%) of the total system energy. To save on storage energy, the DRAM should be small and the disk should be spun down for long periods of time. We show that this can be achieved for predominantly streaming workloads by connecting the disk to the DRAM via a large non-volatile memory (NVM). We refer to this as the NVM-based architecture (NVMBA); the conventional architecture with only a DRAM and a disk is referred to as DRAMBA. The NVM in the NVMBA acts as a traffic reshaper from the disk to the DRAM. The total system costs are balanced, since the cost increase due to adding the NVM is compensated by the decrease in DRAM cost. We analyze the energy saving of NVMBA, with NAND flash memory serving as NVM, relative to DRAMBA with respect to (1) the streaming demand, (2) the disk form factor, (3) the best-effort provision, and (4) the stream location on the disk. We present a worst-case analysis of the reliability of the disk drive and the flash memory, and show that a small flash capacity is sufficient to operate the system over a year at negligible cost. Disk lifetime is superior to flash, so that is of no concern

KALwEN: A New Practical and Interoperable Key Management Scheme for Body Sensor Networks

Key management is the pillar of a security architecture. Body sensor networks(BSNs) pose several challenges -- some inherited from wireless sensor networks(WSNs), some unique to themselves -- that require a new key management scheme to be tailor-made. The challenge is taken on, and the result is KALwEN, a new lightweight scheme that combines the best-suited cryptographic techniques in a seamless framework. KALwEN is user-friendly in the sense that it requires no expert knowledge of a user, and instead only requires a user to follow a simple set of instructions when bootstrapping or extending a network. One of KALwEN's key features is that it allows sensor devices from different manufacturers, which expectedly do not have any pre-shared secret, to establish secure communications with each other. KALwEN is decentralized, such that it does not rely on the availability of a local processing unit (LPU). KALwEN supports global broadcast, local broadcast and neighbor-to-neighbor unicast, while preserving past key secrecry and future key secrecy. The fact that the cryptographic protocols of KALwEN have been formally verified also makes a convincing case

How migrating 0.0001% of address space saves 12% of energy in hybrid storage

We present a simple, operating-\ud system independent method to reduce the num-\ud ber of seek operations and consequently reduce\ud the energy consumption of a hybrid storage\ud device consisting of a hard disk and a flash\ud memory. Trace-driven simulations show that\ud migrating a tiny amount of the address space\ud (0.0001%) from disk to flash already results\ud in a significant storage energy reduction (12%)\ud at virtually no extra cost. We show that the\ud amount of energy saving depends on which part\ud of the address space is migrated, and we present\ud two indicators for this, namely sequentiality and\ud request frequency. Our simulations show that\ud both are suitable as criterion for energy-saving\ud file placement methods in hybrid storage. We\ud address potential wear problems in the flash\ud subsystem by presenting a simple way to pro-\ud long its expected lifetime.\u

Security Attributes Based Digital Rights Management

Most real-life systems delegate responsibilities to different authorities. We apply this model to a digital rights management system, to achieve flexible security. In our model a hierarchy of authorities issues certificates that are linked by cryptographic means. This linkage establishes a chain of control, identity-attribute-rights, and allows flexible rights control over content. Typical security objectives, such as identification, authentication, authorization and access control can be realised. Content keys are personalised to detect illegal super distribution. We describe a working prototype, which we develop using standard techniques, such as standard certificates, XML and Java. We present experimental results to evaluate the scalability of the system. A formal analysis demonstrates that our design is able to detect a form of illegal super distribution

Novel African trypanocidal agents: membrane rigidifying peptides

The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased rigidity of the plasma membrane. Structural analysis of lipid-associated peptide suggests a mechanism of phospholipid clamping in which an internal hydrophobic bulge anchors the peptide in the membrane and positively charged moieties at the termini coordinate phosphates of the polar lipid headgroups. This mechanism reveals a necessary phenotype in bloodstream form African trypanosomes, high membrane fluidity, and we suggest that targeting the plasma membrane lipid bilayer as a whole may be a novel strategy for the development of new pharmaceutical agents. Additionally, the peptides we have described may be valuable tools for probing the biosynthetic machinery responsible for the unique composition and characteristics of African trypanosome plasma membranes

Isolation of Circulating Tumour Cells in Patients With Glioblastoma Using Spiral Microfluidic Technology – A Pilot Study

Glioblastoma (GBM) is the most common and aggressive type of tumour arising from the central nervous system. GBM remains an incurable disease despite advancement in therapies, with overall survival of approximately 15 months. Recent literature has highlighted that GBM releases tumoural content which crosses the blood-brain barrier (BBB) and is detected in patients' blood, such as circulating tumour cells (CTCs). CTCs carry tumour information and have shown promise as prognostic and predictive biomarkers in different cancer types. Currently, there is limited data for the clinical utility of CTCs in GBM. Here, we report the use of spiral microfluidic technology to isolate CTCs from whole blood of newly diagnosed GBM patients before and after surgery, followed by characterization for GFAP, cell-surface vimentin protein expression and EGFR amplification. CTCs were found in 13 out of 20 patients (9/20 before surgery and 11/19 after surgery). Patients with CTC counts equal to 0 after surgery had a significantly longer recurrence-free survival (p=0.0370). This is the first investigation using the spiral microfluidics technology for the enrichment of CTCs from GBM patients and these results support the use of this technology to better understand the clinical value of CTCs in the management of GBM in future studies