61,544 research outputs found

    Drag coefficients for partially inflated flat circular parachutes

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    Free-body tests of flat circular parachutes and determination of aerodynamic drag coefficients during partial inflatio

    Comparison of boiler feed pumps for cesium and potassium Rankine cycle systems

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    Comparison of electromagnetic and centrifugal pumps for cesium and potassium Rankine cycle system

    Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins

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    Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4. Here we map representatives of groups A, B, and G. Restriction fragments from a full-length clone of Sindbis virus, Toto1101, were replaced with the corresponding fragments from the various mutants. These hybrid plasmids were transcribed in vitro by SP6 RNA polymerase to produce infectious RNA transcripts, and the virus recovered was tested for temperature sensitivity. After each lesion was mapped to a specific region, cDNA clones of both mutants and revertants were sequenced in order to determine the precise nucleotide change responsible for each mutation. Synthesis of viral RNA and complementation by rescued mutants were also examined in order to study the phenotype of each mutation in a uniform genetic background. The single mutant of group B, ts11, had a defect in nsP1 (Ala-348 to Thr). All of the group A and group G mutants examined had lesions in nsP2 (Ala-517 to Thr in ts17, Cys-304 to Tyr in ts21, and Gly-736 to Ser in ts24 for three group A mutants, and Phe-509 to Leu in ts18 and Asp-522 to Asn in ts7 for two group G mutants). In addition, ts7 had a change in nsP3 (Phe-312 to Ser) which also rendered the virus temperature sensitive and RNA-. Thus, changes in any of the four nonstructural proteins can lead to failure to synthesize RNA at a nonpermissive temperature, indicating that all four are involved in RNA synthesis. From the results presented here and from previous results, several of the activities of the nonstructural proteins can be deduced. It appears that nsP1 may be involved in the initiation of minus-strand RNA synthesis. nsP2 appears to be involved in the initiation of 26S RNA synthesis, and in addition it appears to be a protease that cleaves the nonstructural polyprotein precursors. It may also be involved in shutoff of minus-strand RNA synthesis. nsP4 appears to function as the viral polymerase or elongation factor. The functions of nsP3 are as yet unresolved

    A new nickel-base wrought superalloy for applications up to 1033 K (1400 F)

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    Alloy was melted from high purity raw materials and cast ingots extruded at 1422 K. Material was hot rolled to 0.013 m diameter bar stock. Partial solution heat-treatment followed by aging produced structure of fine gamma prime precipitate reinforcing gamma matrix containing coarser blocky gamma prime particles. Alloy can be processed by powder metallurgy

    Transition region features observed with Hinode/EIS

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    Two types of active region feature prominent at transition region temperatures are identified in Hinode/EIS data of AR 10938 taken on 2007 January 20. The footpoints of 1 MK TRACE loops are shown to emit strongly in emission lines formed at log T=5.4-5.8, allowing the temperature increase along the footpoints to be clearly seen. A density diagnostic of Mg VII yields the density in the footpoints, with one loop showing a decrease from 3x10^9 cm^-3 at the base to 1.5x10^9 cm^-3 at a projected height of 20 Mm. The second feature is a compact active region transition region brightening which is particularly intense in O V emission (log T=5.4) but also has a signature at temperatures up to log T=6.3. The Mg VII diagnostic gives a density of 4x10^10 cm^-3, and emission lines of Mg VI and Mg VII show line profiles broadened by 50 km/s and wings extending beyond 200 km/s. Continuum emission in the short wavelength band is also found to be enhanced, and is suggested to be free-bound emission from recombination onto He^+.Comment: 11 pages, 9 figures, submitted to PASJ Hinode first results issu

    A paediatric telecardiology service for district hospitals in south-east England: an observational study.

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    The attached article is a Publisher version of the final published version which may be accessed at the link below. Copyright © 2010 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reservedOBJECTIVES: To compare caseloads of new patients assessed by paediatric cardiologists face-to-face or during teleconferences, and assess NHS costs for the alternative referral arrangements. DESIGN: Prospective cohort study over 15 months. SETTING: Four district hospitals in south-east England and a London paediatric cardiology centre. PATIENTS: Babies and children. INTERVENTION: A telecardiology service introduced alongside outreach clinics. MEASUREMENTS: Clinical outcomes and mean NHS costs per patient. RESULTS: 266 new patients were studied: 75 had teleconsultations (19 of 42 newborns and 56 of 224 infants and children). Teleconsultation patients generally were younger (49% being under 1 year compared with 32% seen personally (p = 0.025)) and their symptoms were not as severe. A cardiac intervention was undertaken immediately or planned for five telemedicine patients (7%) and 30 conventional patients (16%). However, similar proportions of patients were discharged after being assessed (32% telemedicine and 39% conventional). During scheduled teleconferences the mean duration of time per patient in sessions involving real-time echocardiography was 14.4 min, and 8.5 min in sessions where pre-recorded videos were transmitted. Mean cost comparisons for telemedicine and face-to-face patients over 14-day and 6-month follow-up showed the telecardiology service to be cost-neutral for the three hospitals with infrequently-held outreach clinics (1519 UK pounds vs 1724 UK pounds respectively after 14 days). CONCLUSION: Paediatric cardiology centres with small cadres of specialists are under pressure to cope with ever-expanding caseloads of new patients with suspected anomalies. Innovative use of telecardiology alongside conventional outreach services should suitably, and economically, enhance access to these specialists.The Department of Health and the Charitable Funds Committee of the Royal Brompton and Harefield NHS Trust funded the project

    Survey of information on turbine bucket erosion

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    Turbine bucket erosion in steam, mercury, and potassium vapor turbines for use in space power plant
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