Learning from a well-documented geotechnical cold case : the Two Towers of Bologna, Italy.

The Garisenda Tower and the Asinelli Tower, also widely known as the Two Towers, are the best preserved and famous medieval towers in the city of Bologna (Northern Italy). Standing one close to the other, right in the heart of the city centre, the Two Towers are delicate remains of the old towered city, which counted more than 75 towers in the 12th century. The foundations of historic towers and the surrounding soil often hide major hazards for the long-term preservation of these heritage structures. The initial fundamental step to this aim is indeed a deep understanding of their original conception, foundations and subsoil. However, the idea that also such elements are an integral part of the overall structure, and thus subjected to the same conservation rules, is relatively new. The present paper outlines the investigation criteria applied to the soil-foundation systems of the Two Towers of Bologna and describes the authenticity of their characteristics, through the interpretation of new experimental data and the analysis of historical documents. A geotechnical perspective on this type of monuments turns out to be crucial in order to effectively understand the soil-structure interaction mechanisms, which govern their safety conditions over time. This study also aims to better understand the reasons why the Two Towers of Bologna, despite their numerous similarities, have reached completely different structural configurations. The methodology described to investigate this case study, which required the integration of several aspects, can be usefully applied to any historic tower

A probabilistic approach to risk assessment of slow slope movements

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Biological therapy in elderly patients with acute myeloid leukemia

Introduction: The introduction of target molecules and immunological therapies is changing the treatment landscape of acute myeloid leukemia (AML). Areas covered: We recapitulate the biological therapies that can be employed in the treatment of elderly patients with AML. Alongside small molecules inhibitors that target specific gene mutations, antibodies, tumor microenvironment modulators, and cellular therapies are being developed for the cure of the disease. Here, we report the biological activities, the efficacy and toxicities of humanized antibodies and antibody-drug conjugates that targets surface antigens as CD33 (gemtuzumab ozogamicine) or CD123 (pivekimab sunirine). We further explore mechanisms and effectiveness of medications that modify the microenvironment, such as glasdegib, or that harness the immune system against leukemia, such as CD47 antibody magrolimab, PD1/PDL1 inhibitors pembrolizumab and nivolumab, TIM3 inhibitor sabatolimab, T-cell and NK-cell engagers. Cellular therapies are considered, even if a large trial is still pending for the feasibility of the approach. In this scenario, a brief overview of the mechanism of action of target agents is provided, particularly with respect to their biological mechanisms. Expert opinion: Overall, this therapeutic armamentarium will constitute the basis for multimodal and personalized combinations that, in the idea of precision medicine, will enormously benefit elderly AML patients

Sensitivity of the spherical gravitational wave detector MiniGRAIL operating at 5 K

We present the performances and the strain sensitivity of the first spherical gravitational wave detector equipped with a capacitive transducer and read out by a low noise two-stage SQUID amplifier and operated at a temperature of 5 K. We characterized the detector performance in terms of thermal and electrical noise in the system output sygnal. We measured a peak strain sensitivity of $1.5\cdot 10^{-20} Hz^{-1/2}$ at 2942.9 Hz. A strain sensitivity of better than $5\cdot 10{-20}Hz{-1/2}$ has been obtained over a bandwidth of 30 Hz. We expect an improvement of more than one order of magnitude when the detector will operate at 50 mK. Our results represent the first step towards the development of an ultracryogenic omnidirectional detector sensitive to gravitational radiation in the 3kHz range.Comment: 8 pages, 5 figures, submitted to Physical Review

Optical absorption parameters of amorphous carbon films from Forouhi–Bloomer and Tauc–Lorentz models: a comparative study

International audienceParametrization models of optical constants, namely Tauc-Lorentz (TL), Forouhi-Bloomer (FB) and modified FB models, were applied to the interband absorption of amorphous carbon films. The optical constants were determined by means of transmittance and reflectance measurements in the visible range. The studied films were prepared by rf sputtering and characterized for their chemical properties. The analytical models were also applied to other optical data published in the literature pertaining to films produced by various deposition techniques. The different approaches used to determine important physical parameters of the interband transition yielded different results. A figure-of-merit was introduced to check the applicability of the models and the results showed that FB modified for an energy dependence of the dipole matrix element adequately represents the interband transition in the amorphous carbons. Further, the modified FB model shows a relative superiority over the TL ones for concerning the determination of the band gap energy, as it is the only one to be validated by an independent, though indirect, gap measurement by x-ray photoelectron spectroscopy. Finally, the application of the modified FB model allowed us to establish some important correlations between film structure and optical absorption properties

The effectiveness of protection systems toward rockfall risk mitigation

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The Garisenda Tower in Bologna: Effects of degradation of selenite basement on its static behaviour

The Garisenda tower in Bologna, a 48 m tall structure with a square base of 7.45 meters per side, is characterized by an overall out of plumb of 3.32m in the South-East direction. Its construction dates back to the XI century and, due to its impressive leaning, in 1350–1353 the original height of 60m was reduced to the 48m of the present day (Cavani 1903; Giordano 2000). The tower can be seen as partitioned in a lower portion, with walls composed by two external leaves of selenite stones filled with rubble conglomerate, and an upper portion where the external leaves are made of masonry bricks. Recent investigations have proved that selenite blocks of the basement have been altered as a result of (a) exposition to high temperatures during important fires, that took place at the end of XIV and XVII centuries, and possibly because of the presence of forges (that were demolished at the end of the XIX centuries) and (b) high level of humidity in the inner lower part of the tower. This process has produced a gradual local disintegration of the selenite stones, leading in some case to a reduction of the original 50 to 60 cm thickness by an amount of about 20 cm. The contribution submitted to this conference is aimed at clarifying this important aspect, linked to the ageing and damage of structural stones and the related consequences in terms of stress distribution and concentrations that could induce fracture propagation and sudden collapse of the tower basement