Useful applications of earth-oriented satellites - Systems for remote-sensing information and distribution, panel 8

Problems and potential use of data gathered by remote sensing from satellites or aircraf

Assessment of explanatory models of mental illness: effects of patient and interviewer characteristics

Background: Explanatory models (EMs) refer to patients’ causal attributions of illness and have been shown to affect treatment preference and outcome. Reliable and valid assessment of EMs may be hindered by interviewer and respondent disparities on certain demographic characteristics, such as ethnicity. The present study examined (a) whether ethnic minority patients reported different EMs to ethnically similar interviewers in comparison with those with a different ethnicity, and (b) whether this effect was related to respondents’ social desirability, the perceived rapport with the interviewer and level of uncertainty toward their EMs. Methods: A total of 55 patients of Turkish and Moroccan origins with mood and anxiety disorders were randomly assigned to ethnically similar or dissimilar interviewers. EMs were assessed, using a semi-structured interview, across 11 different categories of causes. Results: Participants who were interviewed by an ethnically similar interviewer perceived interpersonal, victimization and religious/mystical causes as more important, whereas interviews by ethnically dissimilar interviewers generated higher scores on medical causes. These effects were not mediated by the perceived rapport with the interviewer, and social desirability had a modest impact on the results. Higher uncertainty among participants toward medical and religious/mystical causes seemed to be associated with greater adjustment in the report of these EMs. Conclusion: The findings have significant implications for interviewer selection in epidemiological research and clinical practice

Management of high-risk corneal grafts

MACMILLAN BUILDING,4 CRINAN ST, LONDON, ENGLAND, N1 9X

Group A Streptococcus Secreted Esterase Hydrolyzes Platelet-Activating Factor to Impede Neutrophil Recruitment and Facilitate Innate Immune Evasion

The innate immune system is the first line of host defense against invading organisms. Thus, pathogens have developed virulence mechanisms to evade the innate immune system. Here, we report a novel means for inhibition of neutrophil recruitment by Group A Streptococcus (GAS). Deletion of the secreted esterase gene (designated sse) in M1T1 GAS strains with (MGAS5005) and without (MGAS2221) a null covS mutation enhances neutrophil ingress to infection sites in the skin of mice. In trans expression of SsE in MGAS2221 reduces neutrophil recruitment and enhances skin invasion. The sse deletion mutant of MGAS5005 (ΔsseMGAS5005) is more efficiently cleared from skin than the parent strain. SsE hydrolyzes the sn-2 ester bond of platelet-activating factor (PAF), converting biologically active PAF into inactive lyso-PAF. KM and kcat of SsE for hydrolysis of 2-thio-PAF were similar to those of the human plasma PAF acetylhydrolase. Treatment of PAF with SsE abolishes the capacity of PAF to induce activation and chemotaxis of human neutrophils. More importantly, PAF receptor-deficient mice significantly reduce neutrophil infiltration to the site of ΔsseMGAS5005 infection. These findings identify the first secreted PAF acetylhydrolase of bacterial pathogens and support a novel GAS evasion mechanism that reduces phagocyte recruitment to sites of infection by inactivating PAF, providing a new paradigm for bacterial evasion of neutrophil responses

Internet of things: where to be is to trust

[EN] Networks' creation is getting more and more required, anytime, anywhere. Devices that can participate on these networks can be quite different among them. Sensors, mobiles, home appliances, or other type of devices will have to collaborate to increase and improve the services provided to clients. In the same way, network configuration, security mechanisms establishment, and optimal performance control must be done by them. Some of these devices could have limited resources to work, sometimes even resources restriction not existing, they must work to optimize network traffic. In this article, we center our researching on spontaneous networks. We propose a secure spontaneous ad-hoc network, based on direct peer-to-peer interaction and communities' creation to grant a quick, easy, and secure access to users to surf the Web. Each device will have an identity in the network. Each community will also have an identity and will act as a unity on a world based on Internet connection. Security will be established in the moment they access to the network through the use of the trust chain generated by nodes. Trust is modified by each node on the basis of nodes behaviorLacuesta, R.; Palacios-Navarro, G.; Cetina Englada, C.; Peñalver Herrero, ML.; Lloret, J. (2012). Internet of things: where to be is to trust. EURASIP Journal on Wireless Communications and Networking. (203):1-16. doi:10.1186/1687-1499-2012-203S116203Lipnack J, Stamps J: Virtual Teams: Researching Across Space, Time, and Organizations with Technology. New York: John Wiley and Sons; 1997.Ahuja MK, Carley KN: Network structure in virtual organizations, organization science, Vol. 10, No. 6, Special Issue: Communication Processes for Virtual Organizations, November–December. 1999, 741-757.Mowshowitz A: Virtual organization. Commun ACM 1997, 40(9):30-37. 10.1145/260750.260759Preuß S: CH Cap, Overview of spontaneous networking-evolving concepts and technologies, in Rostocker Informatik-Berichte. Rostock: Fachbereich Informatik der Universit; 2000:113-123.Feeney LM, Ahlgren B, Westerlund A: Spontaneous networking: an application-oriented approach to ad hoc networking. IEEE Commun Mag 2001, 39(6):176-181. 10.1109/35.925687Latvakoski J, Pakkala D, Pääkkönen P: A communication architecture for spontaneous systems. IEEE Wirel Commun 2004, 11(3):36-42. 10.1109/MWC.2004.1308947Mani M, Nguyen A-M, Crespi N: SCOPE: a prototype for spontaneous P2P social networking. Proceedings of 8th IEEE International Conference on Pervasive Computing and Communications Workshops (PERCOM Workshops) 2010, 220-225.Legendre F, de Amorim MD, Fdida S: Implicit merging of overlapping spontaneous networks. Proceedings of Vehicular Technology Conference 2004, 3050-3054.Zarate Silva VH, De Cruz Salgado EI, Ramos Quintana F: AWISPA: an awareness framework for collaborative spontaneous networks. 36th Annual Frontiers in Education Conference 2006, 27-31.Perkins CE, Bhagwat P: Highly dynamic destination sequenced distance-vector routing (DSDV) for mobile computers. Proceedings of the Conference on Communications Architectures, Protocols and Applications (SIGCOMM’94 1994, 234-244.Johnson DB, Maltz DA, Broch J: DSR: The Dynamic Source Routing Protocol for Multihop Wireless Ad Hoc Networks. Boston, MA: Ad Hoc Networking (Addison-Wesley Longman Publishing; 2001.Perkins C, Belding-Royer E, Das S: Ad hoc on-demand distance vector (AODV) routing, RFC 3561. 2003.Park V, Corson MS: IETF MANET Internet Draft “draft-ietf-MANET-tora-spe03.txt”, November 2000. 2012. Accessed March http://tools.ietf.org/html/draft-ietf-manet-tora-spec-03Viana AC, De Amorim MD, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606. 10.1016/j.adhoc.2004.08.006Lacuesta R, Peñalver L: IP addresses configuration in spontaneous networks. In Proceedings of the 9th WSEAS International Conference on Computers. Athens, Greece; 2005:1-6.Alvarez-Hamelin JI, Viana AC, de Amorim M Dias: Architectural considerations for a self-configuring routing scheme for spontaneous networks, Technical Report 1. 2005.Lacuesta R, Peñalver L: Automatic configuration of ad-hoc networks: establishing unique IP link-local addresses. In Proceedings of the International Conference on Emerging Security Information, Systems and Technologies (SECURWARE’07). Valencia, Spain; 2007:157-162.Foulks EF: Social network therapies and society: an overview. Contemp Fam Therapy 1985, 3(4):316-320.IBM: A Smarter Planet. 2012. http://www.ibm.com/smarterplanetMontenegro G, Kushalnagar N, Hui J, Culler D: RFC 4944: Transmission of IPv6 Packets over IEEE 802.15.4 Networks. 2007.Alcaraz C, Najera P, Lopez J, Roman R: Wireless Sensor Networks and the Internet of Things: Do We Need a Complete Integration?, 1st International workshop on the security of The internet of Things (SecIoT). tokyo (Japan); 2010. . Accessed January 2012 1er International Workshop on the Security of The Internet of Things (SecIoT 2010) http://www.nics.uma.es/seciot10/files/pdf/alcaraz_seciot10_paper.pdfFerscha A, Davies N, Schmidt A, Streitz N: Pervasive Socio-Technical Fabric. Procedia Computer Science 2011, 7: 88-91.Hubaux JP, Buttyán L, Capkun S: The quest for security in mobile ad-hoc networks, in Proceedings of the ACM Symposium on Mobile Ad-hoc Networking and Computing. 2001, 146-155.Wang Y, Varadharajan V: Interaction trust evaluation in decentralized environments, e-commerce and web technologies. In Proceedings of 5th International Conference on Electronic Commerce and Web Technologies, vol LNCS 3182. Springer; 2004:144-153.Jimin L, Junbao L, Aiguo A, Zhenpeng L: Two-way trust evaluation based on feedback. in Conference on Logistics Systems and Intelligent Management 2010, 3: 1910-1914.Daskapan S, Nurtanti I, Van den Berg J: Trust algorithms in P2P file sharing networks. Int J Internet Technol Secured Trans 2010, 2(1–2):174-200.Maña A, Koshutanski H, Pérez EJ: A trust negotiation based security framework for service provisioning in load-balancing clusters. Comput Secur 2012, 31(1):4-25. 10.1016/j.cose.2011.11.006Stajano F, Anderson R: The resurrecting duckling security issues for ad-hoc wireless networks. Security Protocols, 7th International Workshop Proceedings, Lecture notes in Computer Science, LNCS 1296 1999, 172-194.Balfanz D, Smetters DK, Stewart P, ChiWong H: Talking to strangers: authentication in ad-hoc wireless networks, in Symposium on Network and Distributed Systems Security (NDSS’02). San Diego, CA; 2002.Capkun S, Hubaux JP, Buttyán L: Mobility helps security in ad-hoc networks. In Proceedings of the 4th ACM international symposium on Mobile ad hoc networking & computing. MD, USA: Annapolis; 2003:46-56.Metzger MJ: Privacy, trust, and disclosure: exploring barriers to electronic commerce. J Comput-Mediat Commun 2004, 9(4). http://jcmc.indiana.edu/vol9/issue4/metzger.html 2004, 9(4)

A spontaneous ad hoc network to share www access

In this paper, we propose a secure spontaneous ad-hoc network, based on direct peer-to-peer interaction, to grant a quick, easy, and secure access to the users to surf the Web. The paper shows the description of our proposal, the procedure of the nodes involved in the system, the security algorithms implemented, and the designed messages. We have taken into account the security and its performance. Although some people have defined and described the main features of spontaneous ad-hoc networks, nobody has published any design and simulation until today. Spontaneous networking will enable a more natural form of wireless computing when people physically meet in the real world. We also validate the success of our proposal through several simulations and comparisons with a regular architecture, taking into account the optimization of the resources of the devices. Finally, we compare our proposal with other caching techniques published in the related literature. The proposal has been developed with the main objective of improving the communication and integration between different study centers of low-resource communities. That is, it lets communicate spontaneous networks, which are working collaboratively and which have been created on different physical places.Authors want to give thanks to the anonymous reviewers for their valuable suggestions, useful comments, and proofreading of this paper. This work was partially supported by the Ministerio de Educacion y Ciencia, Spain, under Grant no. TIN2008-06441-C02-01, and by the "Ayudas complementarias para proyectos de I+D para grupos de calidad de la Generalitat Valenciana" (ACOMP/2010/005).Lacuesta Gilaberte, R.; Lloret, J.; García Pineda, M.; Peñalver Herrero, ML. (2010). A spontaneous ad hoc network to share www access. EURASIP Journal on Wireless Communications and Networking. 2010:1-16. https://doi.org/10.1155/2010/232083S1162010Preuß S, Cap CH: Overview of spontaneous networking-evolving concepts and technologies. In Rostocker Informatik-Berichte. Volume 24. Fachbereich Informatik der Universit at Rostock; 2000:113-123.Gallo S, Galluccio L, Morabito G, Palazzo S: Rapid and energy efficient neighbor discovery for spontaneous networks. Proceedings of the 7th ACM International Symposium on Modeling, Analysis and Simulation of Wireless and Mobile Systems, October 2004, Venice, ItalyLatvakoski J, Pakkala D, Pääkkönen P: A communication architecture for spontaneous systems. IEEE Wireless Communications 2004, 11(3):36-42. 10.1109/MWC.2004.1308947Zarate Silva VH, De Cruz Salgado EI, Quintana FR: AWISPA: an awareness framework for collaborative spontaneous networks. Proceedings of the 36th ASEE/IEEE Frontiers in Education Conference (FIE '06), October 2006 1-6.Feeney LM, Ahlgren B, Westerlund A: Spontaneous networking: an application-oriented approach to ad hoc networking. IEEE Communications Magazine 2001, 39(6):176-181. 10.1109/35.925687Perkins CE, Bhagwat P: Highly dynamic destination-sequenced distance-vector routing (DSDV) for mobile computers. Proceedings of the Conference on Communications Architectures, Protocols and Applications (SIGCOMM '94), August 1994 234-244.Johnson DB, Maltz DA, Broch J: DSR: The Dynamic Source Routing Protocol for Multihop Wireless Ad Hoc Networks, Ad Hoc Networking. Addison-Wesley Longman Publishing, Boston, Mass, USA; 2001.Perkins C, Belding-Royer E, Das S: Ad hoc on-demand distance vector (AODV) routing. RFC 3561, July 2003Park V, Corson MS: IETF MANET Internet Draft "draft-ietf-MANET-tora-spe03.txt". Novemmer 2000.Viana AC, De Amorim MD, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606.Gilaberte RL, Herrero LP: IP addresses configuration in spontaneous networks. Proceedings of the 9th WSEAS International Conference on Computers, July 2005, Athens, GreeceViana AC, Dias de Amorim M, Fdida S, de Rezende JF: Self-organization in spontaneous networks: the approach of DHT-based routing protocols. Ad Hoc Networks 2005, 3(5):589-606.Alvarez-Hamelin JI, Carneiro Viana A, Dias De Amorim M: Architectural considerations for a self-configuring routing scheme for spontaneous networks.,Tech. Rep. 1 October 2005.Lacuesta R, Peñalver L: Automatic configuration of ad-hoc networks: establishing unique IP link-local addresses. Proceedings of the International Conference on Emerging Security Information, Systems and Technologies (SECURWARE '07), October 2007, Valencia, SpainFoulks EF: Social network therapies and society: an overview. Contemporary Family Therapy 1985, 3(4):316-320.Wang Y, Wu H: DFT-MSN: the delay/fault-tolerant mobile sensor network for pervasive information gathering. Proceedings of the 25th IEEE International Conference on Computer Communications (INFOCOM '06), April 2006Kindberg T, Zhang K: Validating and securing spontaneous associations between wireless devices. In Proceedings of the 6th Information Security Conference (ISC '03), 2003. Springer; 44-53.Al-Jaroodi J: Routing security in open/dynamic mobile ad hoc networks. The International Arab Journal of Information Technology 2007, 4(1):17-25.Stajano F, Anderson RJ: The resurrecting duckling: security issues for ad-hoc wireless networks. Proceedings of the 7th International Workshop on Security Protocols, April 1999 172-194.Zhou L, Haas ZJ: Securing ad hoc networks. IEEE Network 1999, 13(6):24-30. 10.1109/65.806983Hauspie M, Simplot-Ryl I: Cooperation in ad hoc networks: enhancing the virtual currency based models. Proceedings of the 1st International Conference on Integrated Internet Ad Hoc and Sensor Networks (InterSense '06), May 2006, Nice, FranceWang X, Dai F, Qian L, Dong H: A way to solve the threat of selfish and malicious nodes for ad hoc networks. Proceedings of the International Symposium on Information Science and Engieering (ISISE '08), December 2008, Shanghai, China 1: 368-370.Kargl F, Klenk A, Weber M, Schlott S: Sensors for detection of misbehaving nodes in MANETs. Detection of Intrusion and Malware and Vulnerability Assessment (DIMVA '04), July 2004, Dortmund, Germany 83-97.Kargl F, Geiss A, Scholott S, Weber M: Secure dynamic source routing. Proceedings of the 38th Annual Hawaii International Conference on System Sciences (HICSS '05), January 2005, Big Island, Hawaii, USAGokhale S, Dasgupta P: Distributed authentication for peer-to-peer networks. Proceedings of the Symposium on Applications and the Internet Workshops, January 2003 347-353.Capkun S, Buttyán L, Hubaux J-P: Self-organized public-key management for mobile ad hoc networks. IEEE Transactions on Mobile Computing 2003, 2(1):52-64. 10.1109/TMC.2003.1195151Stajano F, Anderson R: The resurrecting duckling security issues for ad-hoc wireless networks. In Proceedings of the 7th International Workshop on Security Protocols, 1999, Berlin, Germany, Lecture Notes in Computer Science. Volume 1796. Springer; 172-194.Balfanz D, Smetters DK, Stewart P, Wong HC: Talking to strangers: authentication in ad-hoc wireless networks. Proceedings of the International Symposium on Network and Distributed Systems Security (NDSS '02), February 2002, San Diego, Calif, USABarbara D, Imielinski T: Sleepers and workaholics: caching strategies in mobile environments. Proceedings of the ACM SIGMOD International Conference on Management of Data, May 1994 1-12.Cao G: A scalable low-latency cache invalidation strategy for mobile environments. IEEE Transactions on Knowledge and Data Engineering 2003, 15(5):1251-1265. 10.1109/TKDE.2003.1232276Hu Q, Lee D: Cache algorithms based on adaptive invalidation reports for mobile environments. Cluster Computing 1998, 1(1):39-50. 10.1023/A:1019012927328Jing J, Elmagarmid A, Helal A, Alonso R: Bit-sequences: an adaptive cache invalidation method in mobile client/server environments. Mobile Networks and Applications 1997, 2(2):115-127. 10.1023/A:1013616213333Kahol A, Khurana S, Gupta S, Srimani P: An efficient cache management scheme for mobile environment. Proceedings of the 20th International Conference on Distributied Computing System (ICDCS '00), April 2000, Taipei, Taiwan 530-537.Kazar M: Synchronization and caching issues in the Andrew file system. Proceedings of USENIX Conference, February 1988, Dallas, Tex, USA 27-36.Roussopoulos M, Baker M: CUP: controlled update propagation in peer-to-peer networks. Proceedings of USENIX Annual Technical Conference, June 2003, San Antonio, Tex, USASandberg S, Kleiman S, Goldberg D, Walsh D, Lyon B: Design and implementation of the sun network file system. Proceedings of USENIX Summer Conference, June 1985, Portland, Ore, USA 119-130.Wu K, Yu PS, Chen M: Energy-efficient caching for wireless mobile computing. Proceedings of the 12th IEEE International Conference on Data Engineering, February-March 1996, New Orleans, La, USA 336-343.Yeung MKH, Kwok Y-K: Wireless cache invalidation schemes with link adaptation and downlink traffic. IEEE Transactions on Mobile Computing 2005, 4(1):68-83.Wessels D, Claffy K: Internet cache protocol (IC) v.2. http://www.ietf.org/rfc/rfc2186.txtFan L, Cao P, Almeida J, Broder AZ: Summary cache: a scalable wide-area web cache sharing protocol. IEEE/ACM Transactions on Networking 2000, 8(3):281-293. 10.1109/90.851975Dykes SG, Robbins KA: A viability analysis of cooperative proxy caching. Proceedings of the 20th Annual Joint Conference of the IEEE Computer and Communications Societies (INFOCOM '01), April 2001, Anchorage, Alaska, USA 3: 1205-1214.Wessels D, Claffy K: RFC 2186: Internet cache protocol (ICP), version 2. The Internet Engineering Taskforce, September 1997Wessels D, Claffy K: RFC 2187: application of internet cache protocol (ICP), version 2. The Internet Engineering Taskforce, September 1997Ren Q, Dunhan MH: Using semantic caching to manage location dependent data in mobile computing. Proceedings of the 6th Annual International Conference on Mobile Computing and Networking, August 2000, Boston, Mass, USA 210-221.Lim S, Lee W-C, Cao G, Das CR: Cache invalidation strategies for internet-based mobile ad hoc networks. Computer Communications 2007, 30(8):1854-1869. 10.1016/j.comcom.2007.02.020Park B-N, Lee W, Lee C: QoS-aware internet access schemes for wireless mobile ad hoc networks. Computer Communications 2007, 30(2):369-384. 10.1016/j.comcom.2006.09.004Hara T: Effective replica allocation in ad hoc networks for improving data accessibility. Proceedings of the 20th Annual Joint Conference of the IEEE Computer and Communications Societies (INFOCOM '01), April 2001, Anchorage, Alaska, USA 1568-1576.Papadopouli M, Schulzrinne H: Effects of power conservation, wireless converage and cooperation on data dissemination among mobile devices. Proceedings of the ACM International Symposium on Mobile Ad Hoc Networking and Computing (MobiHoc '01), October 2001, Long Beach, Calif, USA 117-127.Can P, Irani S: Cost-aware WWW proxy caching algorithms. Proceedings of the USENIX Symposium on lnternet Technology and Systems, December 1997Rizzo L, Vicisano L: Replacement policies for a proxy cache. IEEE/ACM Transactions on Networking 2000, 8(2):158-170. 10.1109/90.842139Williams S, Abrams M, Strandridge CR, Abdulla G, Fox EA: Removal policies in network caches for world-wide web documents. Proceedings of the ACM SIGCOMM Conference on Applications, Technologies, Architectures, and Protocols for Computer Communications, August 1996, Palo Alto, Calif, USA 293-305.Hara T: Replica allocation in ad hoc networks with period data update. 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Proceedings of the 18th IEEE Symposium on Reliable Distributed Systems (SRDS '99), October 1999, Lausanne, Switzerland 4-13.Corson MS, Macker JP, Cirincione GH: Internet-based mobile ad hoc networking. IEEE Internet Computing 1999, 3(4):63-70. 10.1109/4236.780962Lim S, Lee W-C, Cao G, Das CR: A novel caching scheme for improving internet-based mobile ad hoc networks performance. Ad Hoc Networks 2006, 4(2):225-239. 10.1016/j.adhoc.2004.04.013Opnet Modeler http://www.opnet.com/solutions/network_rd/modeler_wireless.htmlLacuesta R, Lloret J, Garcia M, Peñalver L: Two secure and energy-saving spontaneous ad-hoc protocol for wireless mesh client networks. Journal of Network and Computer Applications. In pres

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes

The authors thank Dr. John M Asara, Min Yuan, and Susanne Breitkopf for their technical help with metabolomics experiments, Dr. Ben Fowler for his technical help with TEM experiments and also Tina B McKay for many thoughtful discussions and scientific insights during the study.Purpose To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients. Methods Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with Vitamin C stimulation in order to allow for extracellular matrix (ECM) secretion and assembly. Results Our data indicated altered cellular morphology, increased cellular migration, increased ECM assembly, and severe mitochondrial damage in both T1DM and T2DMs when compared to HCFs. Furthermore, we found significant downregulation of Collagen I and Collagen V expression in both T1DM and T2DMs. Furthermore, a significant up regulation of fibrotic markers was seen, including α-smooth muscle actin in T2DM and Collagen III in both T1DM and T2DMs. Metabolic analysis suggested impaired Glycolysis and Tricarboxylic acid cycle (TCA) pathway. Conclusion DM has significant effects on physiological and clinical aspects of the human cornea. The benefits in developing and fully characterizing our 3D in vitro model are enormous and might provide clues for the development of novel therapeutics.Yeshttp://www.plosone.org/static/editorial#pee

Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio