A stereocontrolled synthesis of (−)-detoxinine from L -ascorbic acid

none3A stereoselective synthesis of (−)-detoxinine, the core unit of the detoxifying agent detoxin D1, is presented. The approach, characterized by the use of an inexpensive starting material and by the easy and stereoselective preparation of the key 4,5-disubstituted oxazolidin-2-one 11, proves to be a suitable alternative to the known procedures.openDELLE MONACHE G.; MISITI D.; ZAPPIA G.DELLE MONACHE, G.; Misiti, D.; Zappia, Giovann

Catching what we can't see: manual interception of occluded fly-ball trajectories

Control of interceptive actions may involve fine interplay between feedback-based and predictive mechanisms. These processes rely heavily on target motion information available when the target is visible. However, short-term visual memory signals as well as implicit knowledge about the environment may also contribute to elaborate a predictive representation of the target trajectory, especially when visual feedback is partially unavailable because other objects occlude the visual target. To determine how different processes and information sources are integrated in the control of the interceptive action, we manipulated a computer-generated visual environment representing a baseball game. Twenty-four subjects intercepted fly-ball trajectories by moving a mouse cursor and by indicating the interception with a button press. In two separate sessions, fly-ball trajectories were either fully visible or occluded for 750, 1000 or 1250 ms before ball landing. Natural ball motion was perturbed during the descending trajectory with effects of either weightlessness (0 g) or increased gravity (2 g) at times such that, for occluded trajectories, 500 ms of perturbed motion were visible before ball disappearance. To examine the contribution of previous visual experience with the perturbed trajectories to the interception of invisible targets, the order of visible and occluded sessions was permuted among subjects. Under these experimental conditions, we showed that, with fully visible targets, subjects combined servo-control and predictive strategies. Instead, when intercepting occluded targets, subjects relied mostly on predictive mechanisms based, however, on different type of information depending on previous visual experience. In fact, subjects without prior experience of the perturbed trajectories showed interceptive errors consistent with predictive estimates of the ball trajectory based on a-priori knowledge of gravity. Conversely, the interceptive responses of subjects previously exposed to fully visible trajectories were compatible with the fact that implicit knowledge of the perturbed motion was also taken into account for the extrapolation of occluded trajectories

Bioactive Phenolic Compounds from Aerial Parts of Plinia glomerata

Abstract The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3′-trimethoxy flavellagic acid (1), 3,4,3′-trimethoxy flavellagic acid 4′-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID50 = 3.9 mg/kg, i. p., or 10.8 μmol/kg) and 3 (ID50 = 1.3 mg/kg or 2.5 μmol/kg) were notably more active than some well-known analgesic drugs used here for comparison

Rhythmic tapping to a moving beat motion kinematics overrules natural gravity

beat induction is the cognitive ability that allows humans to listen to a regular pulse in music and move in synchrony with it. although auditory rhythmic cues induce more consistent synchronization than flashing visual metronomes, this auditory-visual asymmetry can be canceled by visual moving stimuli. here, we investigated whether the naturalness of visual motion or its kinematics could provide a synchronization advantage over flashing metronomes. Subjects were asked to tap in sync with visual metronomes defined by vertically accelerating/decelerating motion, either congruent or not with natural gravity; horizontally accelerating/decelerating motion; or flashing stimuli. we found that motion kinematics was the predominant factor determining rhythm synchronization, as accelerating moving metronomes in any cardinal direction produced more precise and predictive tapping than decelerating or flashing conditions. our results support the notion that accelerating visual metronomes convey a strong sense of beat, as seen in the cueing movements of an orchestra director

Flavonoids, benzophenones and a new euphane derivative from Clusia columnaris Engl.

The polyisoprenylated benzophenones machuone and clusiachromene A have been isolated from the fruits of Clusia columnaris. The hexane extract of the young branches with leaves afforded a new euphane derivative, whose structure was elucidated by spectroscopic methods. On the contrary, the most polar EtOAc and ButOH extracts were constituted of flavonoid C-glucosides (isovitexin, vitexin and vitexin-2"-xyloside) and seven biflavonoids of the so-called Garcinia group. Dos frutos de Clusia columnaris foram isoladas as benzofenonas poliisopreniladas machuona e clusiacromeno A. Do extrato em hexano obtido de galhos e folhas novas, um novo triterpeno do tipo eufano foi isolado. Sua estrutura foi elucidada através de métodos espectroscópicos. Por outro lado, dos extratos mais polares - em acetato de etila e em butanol, foram isolados os flavonóides C-glicosilados isovitexina, vitexina e vitexina-2"-xilosídeo, além de sete bisflavonóides conhecidos como bisflavonóides do grupo da Garcinia

A Lunar Laser Ranging Retroreflector Array for the 21st Century

Abstract Over the past 40 years, the Lunar Laser Ranging Program (LLRP) to the Apollo Cube Corner (CCR) Retroreflector Arrays (ALLRRA) [1] has supplied almost all of the significant tests of General Relativity. The LLRP has evaluated the PPN parameters, addressed the possible changes in the gravitational constant and the properties of the self-energy of the gravitational field. In addition, the LLRP has provided significant information on the composition and origin of the moon. This is the only Apollo experiment that is still in operation. Initially the ALLRRAs contributed a negligible fraction of the ranging error budget. Over the decades, the ranging capabilities of the ground stations have improved by more than two orders of magnitude. Now, because of the lunar librations, the existing Apollo retroreflector arrays contribute a significant fraction of the limiting errors in the range measurements. The University of Maryland, as the Principal Investigator for the original Apollo arrays, is now proposing a new approach to the Lunar Laser Array technology [2] . The investigation of this new technology, with Professor Currie as Principal Investigator, is currently being supported by two NASA programs and by the INFN-LNF in Frascati, Italy. Thus after the proposed installation during the next lunar landing, the new arrays will support ranging observations that are a factor 100 more accurate than the current ALLRRAs. The new fundamental cosmological physics and the lunar physics [3] that this new Lunar Laser Ranging Retroreflector Array for the 21st Century (LLRRA-21) can provide will be described. In the design of the new array, there are three major challenges: (1) validate the ability to fabricate a CCR of the required specifications, which is significantly beyond the properties of current CCRs, (2) address the thermal and optical effects of the absorption of solar radiation within the CCR, reduce the transfer of heat from the CCR housing and (3) validate an accurate emplacement technique to install the CCR package on the lunar surface. The latter requires a long-term stable relation between the optical center of the array and the deep regolith, that is, below the thermally driven expansion and contraction of the regolith during the lunar day/night cycle

A Lunar Laser Ranging Retroreflector Array for the 21st Century

Abstract To date, lunar laser ranging to the Apollo retroreflector arrays, which are still operational after four decades, has produced some of the best tests of General Relativity. Since the ground Observatories have improved their accuracy by a factor of 200, the lunar hardware, due to the lunar librations, now limits the ranging accuracy. The Lunar Laser Ranging Retroreflector Array for the 21st Century program plans to deploy new packages that will improve the ranging accuracy by a factor of ten to one hundred in the next few years

Interception of vertically approaching objects: temporal recruitment of the internal model of gravity and contribution of optical information

introduction: recent views posit that precise control of the interceptive timing can be achieved by combining on-line processing of visual information with predictions based on prior experience. Indeed, for interception of free-falling objects under gravity's effects, experimental evidence shows that time-to-contact predictions can be derived from an internal gravity representation in the vestibular cortex. however, whether the internal gravity model is fully engaged at the target motion outset or reinforced by visual motion processing at later stages of motion is not yet clear. moreover, there is no conclusive evidence about the relative contribution of internalized gravity and optical information in determining the time-to-contact estimates.methods: we sought to gain insight on this issue by asking 32 participants to intercept free falling objects approaching directly from above in virtual reality. object motion had durations comprised between 800 and 1100 ms and it could be either congruent with gravity (1 g accelerated motion) or not (constant velocity or -1 g decelerated motion). we analyzed accuracy and precision of the interceptive responses, and fitted them to bayesian regression models, which included predictors related to the recruitment of a priori gravity information at different times during the target motion, as well as based on available optical information.results: consistent with the use of internalized gravity information, interception accuracy and precision were significantly higher with 1 g motion. moreover, bayesian regression indicated that interceptive responses were predicted very closely by assuming engagement of the gravity prior 450 ms after the motion onset, and that adding a predictor related to on-line processing of optical information improved only slightly the model predictive power. discussion: thus, engagement of a priori gravity information depended critically on the processing of the first 450 ms of visual motion information, exerting a predominant influence on the interceptive timing, compared to continuously available optical information. finally, these results may support a parallel processing scheme for the control of interceptive timing

Elevated alanine aminotransferase in blood donors: role of different factors and multiple viral infections.

Many different aetiological agents stimulate alanine aminotransferase (ALT) production. Viral markers and other aetiologies were investigated in 2166 individuals, randomly selected from 10 000 consecutive blood donors. Elevation of ALT was found in 10.8% of subjects. Grouping donors according to ALT level and correlating with, respectively, hepatitis B core antibody (HBcAb), cytomegalovirus antibody alone, or associated with HBcAb, showed similar findings (high ALT 11.1%, normal 11.6%; high 85.4%, normal 81.4%; high 10.2%, normal 11.0%, respectively). Hepatitis C virus (HCV) antibody was found to be significantly associated with elevated ALT levels (high 1.7%, normal 0.26%). Other causes of ALT elevation were alcohol abuse (17%), obesity (25%) and dyslipidaemia (38%), but in 11% there was no obvious aetiology. Although HCV is a rare cause of elevated ALT in blood donors, it seems to be the only virus, among those tested, to account for liver damage. This may be due to the non-protective role of HCV antibody, the low specificity of ALT, or the pathogenic role of uninvestigated viruses

A Presence- and Performance-Driven Framework to Investigate Interactive Networked Music Learning Scenarios

Cooperative music making in networked environments has been subject of extensive research, scientific and artistic. Networked music performance (NMP) is attracting renewed interest thanks to the growing availability of effective technology and tools for computer-based communications, especially in the area of distance and blended learning applications. We propose a conceptual framework for NMP research and design in the context of classical chamber music practice and learning: presence-related constructs and objective quality metrics are used to problematize and systematize the many factors affecting the experience of studying and practicing music in a networked environment. To this end, a preliminary NMP experiment on the effect of latency on chamber music duos experience and quality of the performance is introduced. The degree of involvement, perceived coherence, and immersion of the NMP environment are here combined with measures on the networked performance, including tempo trends and misalignments from the shared score. Early results on the impact of temporal factors on NMP musical interaction are outlined, and their methodological implications for the design of pedagogical applications are discussed