Alien Registration- Coburn, Mae G. (Lincoln, Penobscot County)

https://digitalmaine.com/alien_docs/7423/thumbnail.jp

Responses of Human Endothelial Cells to Pathogenic and Non-Pathogenic Leptospira Species

Leptospirosis is a widespread zoonotic infection that primarily affects residents of tropical regions, but causes infections in animals and humans in temperate regions as well. The agents of leptospirosis comprise several members of the genus Leptospira, which also includes non-pathogenic, saprophytic species. Leptospirosis can vary in severity from a mild, non-specific illness to severe disease that includes multi-organ failure and widespread endothelial damage and hemorrhage. To begin to investigate how pathogenic leptospires affect endothelial cells, we compared the responses of two endothelial cell lines to infection by pathogenic versus non-pathogenic leptospires. Microarray analyses suggested that pathogenic L. interrogans and non-pathogenic L. biflexa triggered changes in expression of genes whose products are involved in cellular architecture and interactions with the matrix, but that the changes were in opposite directions, with infection by L. biflexa primarily predicted to increase or maintain cell layer integrity, while L. interrogans lead primarily to changes predicted to disrupt cell layer integrity. Neither bacterial strain caused necrosis or apoptosis of the cells even after prolonged incubation. The pathogenic L. interrogans, however, did result in significant disruption of endothelial cell layers as assessed by microscopy and the ability of the bacteria to cross the cell layers. This disruption of endothelial layer integrity was abrogated by addition of the endothelial protective drug lisinopril at physiologically relevant concentrations. These results suggest that, through adhesion of L. interrogans to endothelial cells, the bacteria may disrupt endothelial barrier function, promoting dissemination of the bacteria and contributing to severe disease manifestations. In addition, supplementing antibiotic therapy with lisinopril or derivatives with endothelial protective activities may decrease the severity of leptospirosis

Nonsolar astronomy with the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI)

The Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) is a NASA Small Explorer satellite designed to study hard x-ray and gamma-ray emission from solar flares. In addition, its high-resolution array of germanium detectors can see photons from high-energy sources throughout the Universe. Here we discuss the various algorithms necessary to extract spectra, lightcurves, and other information about cosmic gamma-ray bursts, pulsars, and other astrophysical phenomena using an unpointed, spinning array of detectors. We show some preliminary results and discuss our plans for future analyses. All RHESSI data are public, and scientists interested in participating should contact the principal author

Isometric Representations of Totally Ordered Semigroups

Let S be a subsemigroup of an abelian torsion-free group G. If S is a positive cone of G, then all C*-algebras generated by faithful isometrical non-unitary representations of S are canonically isomorphic. Proved by Murphy, this statement generalized the well-known theorems of Coburn and Douglas. In this note we prove the reverse. If all C*-algebras generated by faithful isometrical non-unitary representations of S are canonically isomorphic, then S is a positive cone of G. Also we consider G = Z\times Z and prove that if S induces total order on G, then there exist at least two unitarily not equivalent irreducible isometrical representation of S. And if the order is lexicographical-product order, then all such representations are unitarily equivalent.Comment: February 21, 2012. Kazan, Russi

Lorentz violating electrodynamics

After summarizing the most interesting results in the calculation of synchrotron radiation in the Myers-Pospelov effective model for Lorentz invariance violating (LIV) electrodynamics, we present a general unified way of describing the radiation regime of LIV electrodynamics which include the following three different models : Gambini-Pullin, Ellis et al. and Myers-Pospelov. Such unification reduces to the standard approach of radiation in a dispersive and absortive (in general) medium with a given index of refraction. The formulation is presented up to second order in the LIV parameter and it is explicitly applied to the synchrotron radiation case.Comment: 11 pages, extended version of the talk given by L.F. Urrutia in the VI Mexican School: Approaches to Quantum Gravity, Playa del Carmen, Mexico, Nov. 2004. Minor chages in the text and added reference