On the RKKY range function of a one dimensional non interacting electron gas

We show that the pitfalls encountered in earlier calculations of the RKKY range function for a non interacting one dimensional electron gas at zero temperature can be unraveled and successfully dealt with through a proper handling of the impurity potential.Comment: to appear in Phys. Re

Experimental Test of Two-way Quantum Key Distribution in Presence of Controlled Noise

We describe the experimental test of a quantum key distribution performed with a two-way protocol without using entanglement. An individual incoherent eavesdropping is simulated and induces a variable amount of noise on the communication channel. This allows a direct verification of the agreement between theory and practice.Comment: 4 pages, 3 figure

Vehicle Navigation Service Based on Real-Time Traffic Information

GNSS-assisted vehicle navigation services are nowadays very common in most of the developed countries. However, most of those services are either delivered through proprietary technologies, or fall short in flexibility because of the limited capability to couple road information with real-time traffic information. This paper presents the motivations and a brief summary of a vehicle navigation service based on real-time traffic information, delivered through an open protocol that is currently under standardization in the Open Mobile Alliance forum

Covariant Hamiltonian field theory

We study the relationship between the equations of first order Lagrangian field theory on fiber bundles and the covariant Hamilton equations on the finite-dimensional polysymplectic phase space of covariant Hamiltonian field theory. The main peculiarity of these Hamilton equations lies in the fact that, for degenerate systems, they contain additional gauge fixing conditions. We develop the BRST extension of the covariant Hamiltonian formalism, characterized by a Lie superalgebra of BRST and anti-BRST symmetries.Comment: 35 pages, Late

Minisuperspace Model for Revised Canonical Quantum Gravity

We present a reformulation of the canonical quantization of gravity, as referred to the minisuperspace; the new approach is based on fixing a Gaussian (or synchronous) reference frame and then quantizing the system via the reconstruction of a suitable constraint; then the quantum dynamics is re-stated in a generic coordinates system and it becomes dependent on the lapse function. The analysis follows a parallelism with the case of the non-relativistic particle and leads to the minisuperspace implementation of the so-called {\em kinematical action} as proposed in \cite{M02} (here almost coinciding also with the approach presented in \cite{KT91}). The new constraint leads to a Schr\"odinger equation for the system. i.e. to non-vanishing eigenvalues for the super-Hamiltonian operator; the physical interpretation of this feature relies on the appearance of a ``dust fluid'' (non-positive definite) energy density, i.e. a kind of ``materialization'' of the reference frame. As an example of minisuperspace model, we consider a Bianchi type IX Universe, for which some dynamical implications of the revised canonical quantum gravity are discussed. We also show how, on the classical limit, the presence of the dust fluid can have relevant cosmological issues. Finally we upgrade our analysis by its extension to the generic cosmological solution, which is performed in the so-called long-wavelength approximation. In fact, near the Big-Bang, we can neglect the spatial gradients of the dynamical variables and arrive to implement, in each space point, the same minisuperspace paradigm valid for the Bianchi IX model.Comment: 16 pages, no figures, to appear on International Journal of Modern Physics

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines. Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment. Conversely, U251 cell line showed a resistant phenotype in response to axitinib treatment, as evidenced by cell cycle arrest but no sign of cell death. The combinatorial use of axitinib with other therapies, with the aim of inhibiting multiple signaling pathways involved in tumor growth, can increase the efficiency of this TKI. Thus, we addressed the combined effects of axitinib with no toxic doses of the proteasome inhibitor bortezomib on the growth of U87 and T98 axitinib- sensitive and axitinib-resistant U251 cell lines. Compared to single treatments, combined exposure was more effective in inhibiting cell viability of all glioma cell lines, although with different cell death modalities. The regulation of key DDR and cell cycle proteins, including Chk1, γ-H2AX and p21(Waf1/Cip1) was also studied in glioma cell lines. Collectively, these findings provide new perspectives for the use of axitinib in combination with Bortezomib to overcome the therapy resistance in gliomas