A cholesterol and sucrose rich diet promotes lipoprotein peroxidation and impairs insulin sensitivity in rats

The effects of a diet rich in cholesterol and sucrose on lipoprotein peroxidation and insulin sensitivity were studied in rats. The protective role of fish oil dietary supplementation, both alone and associated with antioxidants, was also investigated. Four groups of 6 male rats were treated for 4 weeks with a standard diet, rich in cholesterol and sucrose (atherogenic diet), atherogenic diet plus fish oil and atherogenic diet plus fish oil enriched in polycosanols, terpenes and antioxidants. Atherogenic diet induced a significant increase in plasma concentration of cholesterol, triglycerides, free fatty acids and atherogenic index; moreover, it significantly enhanced the susceptibility of lipoproteins to peroxidation and the resistance to insulin. Dietary integration with fish oil limited the development of the above risk factors, the association with polycosanols, terpenes and antioxidants being more efficacious than fish oil alone

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 7-BETA-[N-(ARYLMETHYLOXYIMINO) ACETAMIDO]CEPHALOSPORANIC ACID-DERIVATIVES

Some cephalosporanic acid derivatives substituted on the C(7) amino nitrogen with (arylmethyloxyimino) acetyl moieties were synthesized and tested in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria. The new compounds showed a modest activity directed only against Gram positive microorganisms

Synthesis and antimicrobial properties of substituted 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins and cephalosporins

The 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins 13 and cephalosporins 14 and 15 were synthesized and assayed for their antimicrobial activity on Gram-positive and Gram-negative bacteria whether producers of β-lactamases or otherwise. Compounds 13, 14, and 15 exhibited an activity which was generally lower than that of the corresponding phenylacetyl derivative: penicillin G (4), cephaloram (5), and phenylacetamidodesacetoxycephalosporanic acid (6). Furthermore, the comparison of the minimum inhibitory concentration values of some of the new 2-methoxyimino 3-aminoxypropionyl derivatives 13-15 with those of the corresponding ones 1-3 lacking the 2-methoxyimino substituent showed that the introduction of the 2-methoxyimino group of E configuration on the aminoxypropionamido side chain of 1-3 gives compounds (13-15) which do not generally possess better antimicrobial properties

Synthesis and antimicrobial activity of 7ß-(S) and 7ß-(R)-3-(methyleneaminoxy)-2-methylpropionamido substituted cephalosporanic acid derivatives

Some 7-amino cephalosporanic acid derivatives substituted on the C(7) nitrogen with (S)-and (R)-3-(methyleneaminoxy)-2-methylpropionyl groups were synthesised and tested in vitro for their antimicrobial activity against Gram-positive and Gram-negative bacteria. Some of the new compounds showed a modest activity directed only against Gram-positive microorganisms

Synthesis and antimicrobial properties of substituted ß-aminoxypropionyl penicillins and cephalosporins

Some β-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (>C=NOCH2) could be a "bioisoster" of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison