The relationship of dementia prevalence in older adults with intellectual disability (ID) to age and severity of ID

Background: Previous research has shown that adults with intellectual disability (ID) may be more at risk of developing dementia in old age than expected. However, the effect of age and ID severity on dementia prevalence rates has never been reported. We investigated the predictions that older adults with ID should have high prevalence rates of dementia that differ between ID severity groups and that the age-associated risk should be shifted to a younger age relative to the general population. Method: A two-staged epidemiological survey of 281 adults with ID without Down syndrome (DS) aged >60 years; participants who screened positive with a memory task, informant-reported change in function or with the Dementia Questionnaire for Persons with Mental Retardation (DMR) underwent a detailed assessment. Diagnoses were made by psychiatrists according to international criteria. Prevalence rates were compared with UK prevalence and European consensus rates using standardized morbidity ratios (SMRs). Results: Dementia was more common in this population (prevalence of 18.3%, SMR 2.77 in those aged >65 years). Prevalence rates did not differ between mild, moderate and severe ID groups. Age was a strong risk factor and was not influenced by sex or ID severity. As predicted, SMRs were higher for younger age groups compared to older age groups, indicating a relative shift in age-associated risk. Conclusions: Criteria-defined dementia is 2–3 times more common in the ID population, with a shift in risk to younger age groups compared to the general population

Multi-axis manual controllers: A state-of-the-art report

A literature search was carried out to examine the feasibility of a six degree of freedom hand controller. Factors addressed included related areas, approaches to manual control, applications of manual controllers, and selected studies of the human neuromuscular system. Results are presented

Design and development of a six degree of freedom hand controller

The design objectives of a six degree of freedom manual controller are discussed with emphasis on a space environment. Details covered include problems associated with a zero-g environment, the need to accommodate both 'shirt sleeve' and space suited astronauts, the combination of both manipulator operation and spacecraft flight control in a single device, and to accommodate restraints in space. A variable configuration device designed as a development tool in which rotational axes can be moved relative to one another, is described and its limitations discussed. Two additional devices were developed for concept testing. Each device combines the need for good quality with its ability achieve a wide range of adjustments

Six degree of freedom manual controls study report

The feasibility of using degree of freedom manual controls in space in an on orbit environment was determined. Several six degree of freedom controls were tested in a laboratory environment, and replica controls were used to control robot arms. The selection of six degrees of freedom as a design goal was based on the fact that six degrees are sufficient to define the location and orientation of a rigid body in space

Maximization of capacity and p-norms for some product channels

It is conjectured that the Holevo capacity of a product channel \Omega \otimes \Phi is achieved when product states are used as input. Amosov, Holevo and Werner have also conjectured that the maximal p-norm of a product channel is achieved with product input states. In this paper we establish both of these conjectures in the case that \Omega is arbitrary and \Phi is a CQ or QC channel (as defined by Holevo). We also establish the Amosov, Holevo and Werner conjecture when \Omega is arbitrary and either \Phi is a qubit channel and p=2, or \Phi is a unital qubit channel and p is integer. Our proofs involve a new conjecture for the norm of an output state of the half-noisy channel I \otimes \Phi, when \Phi is a qubit channel. We show that this conjecture in some cases also implies additivity of the Holevo capacity

Axion-like-particle decay in strong electromagnetic backgrounds

The decay of a massive pseudoscalar, scalar and U(1) boson into an electron-positron pair in the presence of strong electromagnetic backgrounds is calculated. Of particular interest is the constant-crossed-field limit, relevant for experiments that aim to measure high-energy axion-like-particle conversion into electron-positron pairs in a magnetic field. The total probability depends on the quantum nonlinearity parameter - a product of field and lightfront momentum invariants. Depending on the seed particle mass, different decay regimes are identified. In the below-threshold case, we find the probability depends on a non-perturbative tunnelling exponent depending on the quantum parameter and the particle mass. In the above-threshold case, we find that when the quantum parameter is varied linearly, the probability oscillates nonlinearly around the spontaneous decay probability. A strong-field limit is identified in which the threshold is found to disappear. In modelling the fall-off of a quasi-constant-crossed magnetic field, we calculate probabilities beyond the constant limit and investigate when the decay probability can be regarded as locally constant.Comment: 22 pages, 7 figure

Black Widow Pulsars: the Price of Promiscuity

The incidence of evaporating 'black widow' pulsars (BWPs) among all millisecond pulsars (MSPs) is far higher in globular clusters than in the field. This implies a special formation mechanism for them in clusters. Cluster MSPs in wide binaries with WD companions exchange them for turnoff-mass stars. These new companions eventually overflow their Roche lobes because of encounters and tides. The millisecond pulsars eject the overflowing gas from the binary, giving mass loss on the binary evolution timescale. The systems are only observable as BWPs at epochs where this evolution is slow, making the mass loss transparent and the lifetime long. This explains why observed BWPs have low-mass companions. We suggest that at least some field BWPs were ejected from globular clusters or entered the field population when the cluster itself was disrupted.Comment: 6 pages, 2 figures, MNRAS in pres

Notes on multiplicativity of maximal output purity for completely positive qubit maps

A problem in quantum information theory that has received considerable attention in recent years is the question of multiplicativity of the so-called maximal output purity (MOP) of a quantum channel. This quantity is defined as the maximum value of the purity one can get at the output of a channel by varying over all physical input states, when purity is measured by the Schatten $q$-norm, and is denoted by $\nu_q$. The multiplicativity problem is the question whether two channels used in parallel have a combined $\nu_q$ that is the product of the $\nu_q$ of the two channels. A positive answer would imply a number of other additivity results in QIT. Very recently, P. Hayden has found counterexamples for every value of $q>1$. Nevertheless, these counterexamples require that the dimension of these channels increases with $1-q$ and therefore do not rule out multiplicativity for $q$ in intervals $[1,q_0)$ with $q_0$ depending on the channel dimension. I argue that this would be enough to prove additivity of entanglement of formation and of the classical capacity of quantum channels. More importantly, no counterexamples have as yet been found in the important special case where one of the channels is a qubit-channel, i.e. its input states are 2-dimensional. In this paper I focus attention to this qubit case and I rephrase the multiplicativity conjecture in the language of block matrices and prove the conjecture in a number of special cases.Comment: Manuscript for a talk presented at the SSPCM07 conference in Myczkowce, Poland, 10/09/2007. 12 page