Temporal frequency of radio emissions for the April 25, 1984 flare

The National Geophysical Data Center archives data of the solar-terrestrial environment. The USAF Radio Solar Telescope Network (RSTN) data allow performance of time series analysis to determine temporal oscillations as low as three seconds. The X13/3B flare which erupted in region 4474 (S12E43) on the 24 to 25 of April 1984, was selected. The soft X-rays, 1 to 8 A, remained above X-levels for 50 minutes and the radio emissions measured at Learmonth Solar Observatory reached a maximum of 3.15 x 10 to the 5th power SFUs at 410 MHz at 0000UT. A power spectral analysis of the fixed frequency RSTN data from Learmonth shows possible quasi-periodic fluctuations in the range two to ten seconds. Repetition rates or quasi-periodicities, in the case of the power spectral analysis, generally showed the same trends as the average solar radio flux at 245 and 8800 MHz. The quasi-periodicities at 1415 MHz showed no such trends

PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy

Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process, selective pharmacologic modulators of mitophagy are almost nonexistent. We developed a compound that increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy. The compound, P62-mediated mitophagy inducer (PMI), activates mitophagy without recruiting Parkin or collapsing ΔΨm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway. PMI drives mitochondria to a process of quality control without compromising the bio-energetic competence of the whole network while exposing just those organelles to be recycled. Thus, PMI circumvents the toxicity and some of the nonspecific effects associated with the abrupt dissipation of ΔΨm by ionophores routinely used to induce mitophagy and represents a prototype pharmacological tool to investigate the molecular mechanisms of mitophagy

Elliptical Combing Motion for Harvesting Bell Peppers

A new concept for mechanically harvesting bell peppers, intended specifically for multiple-pass harvesting, utilized spaced horizontal fingers combing vertically upward through plant foliage in an elliptical path alternating from both sides of the row. An apparatus based on this concept was designed and built, and harvest tests were conducted to determine the effect of two main machine operating parameters, vertical picking speed and disk angle. Harvesting performance was evaluated in terms of harvest efficiency, fruit damage, and plant damage as it related to multiple-pass harvesting. Fruit removal, both harvestable size and immature, increased significantly as vertical picking speed increased. Branch breakage also tended to increase as vertical picking speed increased, partially accounting for the increased fruit removal. Fruit damage increased significantly as the disk angle increased. Overall, the average harvest efficiency for the tests was 81% and the average fruit damage was 5.9%

Computer automation of ultrasonic testing

Report describes a prototype computer-automated ultrasonic system developed for the inspection of weldments. This system can be operated in three modes: manual, automatic, and computer-controlled. In the computer-controlled mode, the system will automatically acquire, process, analyze, store, and display ultrasonic inspection data in real-time. Flaw size (in cross-section), location (depth), and type (porosity-like or crack-like) can be automatically discerned and displayed. The results and pertinent parameters are recorded

Breakdown of Lindstedt Expansion for Chaotic Maps

In a previous paper of one of us [Europhys. Lett. 59 (2002), 330--336] the validity of Greene's method for determining the critical constant of the standard map (SM) was questioned on the basis of some numerical findings. Here we come back to that analysis and we provide an interpretation of the numerical results by showing that no contradiction is found with respect to Greene's method. We show that the previous results based on the expansion in Lindstedt series do correspond to the transition value but for a different map: the semi-standard map (SSM). Moreover, we study the expansion obtained from the SM and SSM by suppressing the small divisors. The first case turns out to be related to Kepler's equation after a proper transformation of variables. In both cases we give an analytical solution for the radius of convergence, that represents the singularity in the complex plane closest to the origin. Also here, the radius of convergence of the SM's analogue turns out to be lower than the one of the SSM. However, despite the absence of small denominators these two radii are lower than the ones of the true maps for golden mean winding numbers. Finally, the analyticity domain and, in particular, the critical constant for the two maps without small divisors are studied analytically and numerically. The analyticity domain appears to be an perfect circle for the SSM analogue, while it is stretched along the real axis for the SM analogue yielding a critical constant that is larger than its radius of convergence.Comment: 12 pages, 3 figure

Fourier, Gauss, Fraunhofer, Porod and the Shape from Moments Problem

We show how the Fourier transform of a shape in any number of dimensions can be simplified using Gauss's law and evaluated explicitly for polygons in two dimensions, polyhedra three dimensions, etc. We also show how this combination of Fourier and Gauss can be related to numerous classical problems in physics and mathematics. Examples include Fraunhofer diffraction patterns, Porods law, Hopfs Umlaufsatz, the isoperimetric inequality and Didos problem. We also use this approach to provide an alternative derivation of Davis's extension of the Motzkin-Schoenberg formula to polygons in the complex plane.Comment: 21 pages, no figure

Transport properties and magnetic field induced localization in the misfit cobaltite [Bi2_2Ba1.3_{1.3}K0.6_{0.6}Co0.1_{0.1}]RS^{RS}[CoO2_2]1.97_{1.97} single crystal

Resistivity under magnetic field, thermopower and Hall coefficient are systematically studied for [Bi$_2$Ba$_{1.3}$K$_{0.6}$Co$_{0.1}$]$^{RS}$[CoO$_2$]$_{1.97}$ single crystal. In-plane resistivity ($\rho_{ab}$(T)) shows metallic behavior down to 2 K with a $T^2$ dependence below 30 K; while out-of-plane resistivity ($\rho_{c}(T)$) shows metallic behavior at high temperature and a thermal activation semiconducting behavior below about 12 K. Striking feature is that magnetic field induces a ln(1/$T$) diverging behavior in both $\rho_{ab}$ and $\rho_{c}(T)$ at low temperature. The positive magnetoresistance (MR) could be well fitted by the formula based on multi-band electronic structure. The ln(1/$T$) diverging behavior in $\rho_{ab}$ and $\rho_{c}(T)$ could arise from the magnetic-field-induced 2D weak localization or spin density wave.Comment: 7 pages, 8 figure

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) from patients with Duchenne, limb-girdle, and congenital muscular dystrophies. 3D skeletal myogenic differentiation of pluripotent cells was induced within hydrogels under tension to provide myofiber alignment. Artificial muscles recapitulated characteristics of human skeletal muscle tissue and could be implanted into immunodeficient mice. Pathological cellular hallmarks of incurable forms of severe muscular dystrophy could be modeled with high fidelity using this 3D platform. Finally, we show generation of fully human iPSC-derived, complex, multilineage muscle models containing key isogenic cellular constituents of skeletal muscle, including vascular endothelial cells, pericytes, and motor neurons. These results lay the foundation for a human skeletal muscle organoid-like platform for disease modeling, regenerative medicine, and therapy development. : Maffioletti et al. generate human 3D artificial skeletal muscles from healthy donors and patient-specific pluripotent stem cells. These human artificial muscles accurately model severe genetic muscle diseases. They can be engineered to include other cell types present in skeletal muscle, such as vascular cells and motor neurons. Keywords: skeletal muscle, pluripotent stem cells, iPS cells, myogenic differentiation, tissue engineering, disease modeling, muscular dystrophy, organoid

Ion-neutral sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap

Long range polarization forces between ions and neutral atoms result in large elastic scattering cross sections, e.g., 10^6 a.u. for Na+ on Na or Ca+ on Na at cold and ultracold temperatures. This suggests that a hybrid ion-neutral trap should offer a general means for significant sympathetic cooling of atomic or molecular ions. We present SIMION 7.0 simulation results concerning the advantages and limitations of sympathetic cooling within a hybrid trap apparatus, consisting of a linear rf Paul trap concentric with a Na magneto-optical trap (MOT). This paper explores the impact of various heating mechanisms on the hybrid system and how parameters related to the MOT, Paul trap, number of ions, and ion species affect the efficiency of the sympathetic cooling