Уровень сосудистого эндотелиального фактора роста, ракового эмбрионального антигена, кальция и фосфора в сыворотке крови при различных типах опухолей костей

Department of Oncology, Azerbaijan Medical University, BakuBackground: The extent of angiogenesis seems to be an essential prognostic factor in many solid tumors of children and adults. Vascular endothelial growth factor (VEGF) is a proangiogenic cytokine that is highly expressed in many solid tumors often correlating with a poor prognosis. Aim: The aim of the study was to assess the angiogenesis on the basis of serum VEGF levels and also to compare the concentrations in serum of carcinoma embryonic antigen, oxyproline, calcium and phosphorus in different types of bone tumors. Patients and Methods: The research was conducted on 66 patients and also 22 healthy individuals, who were accepted to our clinic. Patients were divided into three groups: primary bone cancer (n = 22), bone metastasis (n = 22), and benign bone tumors (n = 22). Results: VEGF, CEA and oxyproline concentrations were increased in both primary bone tumors and bone metastasis in comparison with healthy individuals and patients with benign tumors (p < 0.05). However, we found statistically significant higher phosphorus levels in all patient groups (p < 0.05), and higher calcium only in the bone metastasis group as compared with controls (p < 0.05). A significant positive correlation existed between VEGF and CEA. Conclusions: High VEGF levels, as a marker of angiogenesis, were associated with primary bone tumors and bone metastasis. The calcium and phosphorus content, in addition to VEGF, CEA and oxyproline levels, could be useful in prognosis and differentiation of the bone tumors. Future studies in larger series are needed to confirm these data. Степень ангиогенеза представляется важным прогностическим фактором для многих солидных опухолей у детей и взрослых. Сосудистый эндотелиальный фактор роста (VEGF) является проангиогенным цитокином, который выявяается во многих солидных опухолях и часто приводит к отрицательным прогнозам. Целью исследования была оценка ангиогенеза, основанная на определении в сыворотке крови уровня VEGF, а также сывороточных концентраций ракового эмбрионального антигена (РЭА), оксипролина, кальция и фосфата в различных типах костных опухолей. В исследование было включено 66 больных, а также 22 здоровых человека. Пациенты были разделены на три группы: с первичными костными опухолями (n = 22), с костными метастазами (n = 22) и с доброкачественными опухолями костей (n = 22). Kонцентрация VEGF, РЭА и оксипролина в сыворотке крови пациентов с первичными и метастатическими опухолями костей была больше, в сравнении с показателями у контрольной группы и у больных с доброкачественными опухолями костей (р < 0,05). Однако, мы обнаружили статистически значимое увеличение уровня фосфора во всех группах (р < 0,05), а кальция только у пациентов с костными метастазами по сравнению с контрольной группой (р < 0,05). Существует значимая положительная корреляция между уровнями VEGF и РЭА. B заключение необходимо отметить, что высокий уровень VEGF в качестве маркера ангиогенеза был выявлен в первичных опухолях костей и при костных метастазах. Определение содержания кальция и фосфора, в дополнение к оценке уровней VEGF, РЭА и оксипролина, может оказаться полезным в оценке прогноза и дифференциации опухолей костей

Potential use of lactic acid bacteria for reduction of allergenicity and for longer conservation of fermented foods

The interest of consumers for diverse fermented foods has increased in recent years thanks to the positive perception of their impact on consumer health considered as beneficial. Hence, there is an evident need for search of novel ways and for new food preservation agents of natural origins. In this aspect, lactic acid bacteria are very good candidates. It should be highlighted also that the onset of food allergies is rising significantly in recent years. The reduction of the immunoreactivity of food proteins could be achieved thanks to pre-prandial proteolysis occurring in fermented dairy (and other food) systems changing the allergen presentation or cleaving the allergenic protein epitopes, and produce hypoallergenic products.Fil: El-Ghaish, Shady. Institut National de la Recherche Agronomique; FranciaFil: Ahmadova, Aynur. Institut National de la Recherche Agronomique; FranciaFil: Hadji-Sfaxi, Imen. Institut National de la Recherche Agronomique; FranciaFil: El Merchefi, Kamel Eddine. Institut National de la Recherche Agronomique; Francia. Université d’Oran. Département de biologie. Laboratoire de Physiologie de la Nutrition et sécurité Alimentaire; ArgeliaFil: Bazukyan, Inga. Yerevan State University. Faculty of Biology; ArmeniaFil: Choiset, Yvan. Institut National de la Recherche Agronomique; FranciaFil: Rabesona, Hanitra. Institut National de la Recherche Agronomique; FranciaFil: Sitohy, Mahmoud. Institut National de la Recherche Agronomique; Francia. Zagazig University. Faculty of Agriculture. Biochemistry Department; EgiptoFil: Popov, Yuri G.. Yerevan State University. Faculty of Biology; ArmeniaFil: Kuliev, Akif A.. Baku State University. Biotechnical and Biochemistry Chair; AzerbaiyánFil: Mozzi, Fernanda Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Chobert, Jean-Marc. Institut National de la Recherche Agronomique; FranciaFil: Haertle, Thomas. Institut National de la Recherche Agronomique; Franci

European study on the attitude of psychiatrists towards their patients

INTRODUCTION: Many people think that people with mental disorders might be dangerous or unpredictable. These patients face various sources of disadvantages and experience discrimination in job interviews, in education, and housing. Mental health-related stigma occurs not only within the public community, it is a growing issue among professionals as well. Our study is the first that investigates the stigmatising attitude of psychiatrists across Europe. OBJECTIVES: We designed a cross-sectional, observational, multi-centre, international study of 33 European countries to investigate the attitude towards patients among medical specialists and trainees in the field of general adult and child and adolescent psychiatry. METHODS: An internet-based, anonymous survey will measure the stigmatising attitude by using the local version of the Opening Minds Stigma Scale for Health Care Providers. Data gathering started in July this year and will continue until December 2020. RESULTS: This study will be the first to describe the stigmatising attitude of psychiatric practitioners across Europe from their perspectives. CONCLUSIONS: The study will contribute to knowledge of gaps in stigmatising attitude towards people with mental health problems and will provide with new directions in anti-stigma interventions. DISCLOSURE: No significant relationships

Cross-cultural analysis of the stigmatising attitudes of psychiatrists across Europe and measurement invariance of the Opening Minds Stigma Scale for healthcare providers

INTRODUCTION: Since the literature investigating the stigmatising attitudes of psychiatrists is scarce, this is the first study which examines the phenomena across Europe. The Opening Minds Stigma Scale for Health Care Providers (OMS-HC) is a widely used questionnaire to measure stigma in healthcare providers towards people with mental illness, although it has not been validated in many European countries. OBJECTIVES: A cross-sectional, observational, multi-centre study was conducted in 32 European countries to investigate the attitudes towards patients among specialists and trainees in general adult and child psychiatry. In order to be able to compare stigma scores across cultures, we aimed to calculate measurement invariance. METHODS: An internet-based, anonymous survey was distributed in the participating countries, which was completed by n=4245 psychiatrists. The factor structure of the scale was investigated by using separate confirmatory factor analyses for each country. The cross-cultural validation was based on multigroup confirmatory factor analyses. RESULTS: When country data were analysed separately, the three dimensions of the OMS-HC were confirmed, and the bifactor model showed the best model fit. However, in some countries, a few items were found to be weak. The attitudes towards patients seemed favourable since stigma scores were less than half of the reachable maximum. Results allowed comparison to be made between stigma scores in different countries and subgroups. CONCLUSIONS: This international cooperation has led to the cross-cultural validation of the OMS-HC on a large sample of practicing psychiatrists. The results will be useful in the evaluation of future anti-stigma interventions and will contribute to the knowledge of stigma. DISCLOSURE: No significant relationships