Computed tomography and magnetic resonance diagnosis of variations in the anatomical location of the major salivary glands in 1680 dogs and 187 cats

During assessment of routine clinical magnetic resonance imaging (MRI) of the heads of dogs, variations in the location of mandibular and zygomatic salivary glands (SGs) were observed incidentally. The aims of this retrospective study were to describe anatomical variations of the major SGs found on MRI and computed tomography (CT) studies of the head in dogs and cats and to investigate possible clinical relevancy. No anatomical variation of the SGs was seen in cats, but in dogs, although variation of the parotid SG was not identified, that of the mandibular SG was found in 33/1680 animals (2%), either unilaterally (6/33 right-sided, 13/33 left-sided) or bilaterally (14/33). The Border terrier breed (19/33, 58%) was over-represented. Each atypically located mandibular SG was positioned medial to the digastric muscle and rostral to the retropharyngeal lymph node. The sublingual glands were difficult to delineate from the mandibular glands. Anatomical variation of one zygomatic gland (3/4 left-sided) was identified in four small-breed dogs (0.2%). Each atypically located zygomatic gland was tilted at the ventrorostral aspect of the masseter muscle underneath the skin surface. MRI and CT characteristics were not different between typically and atypically located SGs. None of the dogs had clinical signs related with SG disease. It was concluded that, with suspected breed predispositions, incidental unilateral or bilateral anatomical variations of mandibular and zygomatic SGs can be encountered in dogs and an awareness of these possible variations may be important in pre-surgical planning

Sudden To Adiabatic Transition in Beta Decay

We discuss effects in beta decays at very low beta energies, of the order of the kinetic energies of atomic electrons. As the beta energy is lowered the atomic response changes from sudden to adiabatic. As a consequence, the beta decay rate increases slightly and the ejection of atomic electrons (shake off) and subsequent production of X rays is turned off. We estimate the transition energy and the change in decay rate. The rate increase is largest in heavy atoms, which have a small Q value in their decay. The X ray switch-off is independent of Q value.Comment: 6 pages LaTe

Relativistic Coulomb Problem: Analytic Upper Bounds on Energy Levels

The spinless relativistic Coulomb problem is the bound-state problem for the spinless Salpeter equation (a standard approximation to the Bethe--Salpeter formalism as well as the most simple generalization of the nonrelativistic Schr\"odinger formalism towards incorporation of relativistic effects) with the Coulomb interaction potential (the static limit of the exchange of some massless bosons, as present in unbroken gauge theories). The nonlocal nature of the Hamiltonian encountered here, however, renders extremely difficult to obtain rigorous analytic statements on the corresponding solutions. In view of this rather unsatisfactory state of affairs, we derive (sets of) analytic upper bounds on the involved energy eigenvalues.Comment: 12 pages, LaTe

Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy

Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer Foundation-7 (MCF-7) cells. The Raman images were treated by K-mean cluster analysis to detect the drug in cells. Distribution of paclitaxel in cells is verified by calculating the correlation coefficient between the reference spectrum of the drug and the whole Raman image spectra. A time dependent gradual diffusion of paclitaxel all over the cell is observed suggesting a complementary picture of the pharmaceutical action of this drug based on rapid binding of free tubulin to crystallized paclitaxel. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4794871

Perturbative reliability of the Higgs-boson coupling in the standard electroweak model

We apply Pade summation to the \beta(\lambda) function for the quartic Higgs coupling \lambda in the standard electroweak model. We use the \beta function calculated to five loops in the minimal subtraction scheme to demonstrate the improvement resulting from the summation, and then apply the method to the more physical on-mass-shell renormalization scheme where \beta is known to three loops. We conclude that the OMS \beta function and the running coupling \lambda(\mu) are reliably known over the range of energies and Higgs-boson masses of current interest.Comment: 14 pages, RevTeX, 6 figure

Discovering the roots: Uniform closure results for algebraic classes under factoring

Newton iteration (NI) is an almost 350 years old recursive formula that approximates a simple root of a polynomial quite rapidly. We generalize it to a matrix recurrence (allRootsNI) that approximates all the roots simultaneously. In this form, the process yields a better circuit complexity in the case when the number of roots $r$ is small but the multiplicities are exponentially large. Our method sets up a linear system in $r$ unknowns and iteratively builds the roots as formal power series. For an algebraic circuit $f(x_1,\ldots,x_n)$ of size $s$ we prove that each factor has size at most a polynomial in: $s$ and the degree of the squarefree part of $f$. Consequently, if $f_1$ is a $2^{\Omega(n)}$-hard polynomial then any nonzero multiple $\prod_{i} f_i^{e_i}$ is equally hard for arbitrary positive $e_i$'s, assuming that $\sum_i \text{deg}(f_i)$ is at most $2^{O(n)}$. It is an old open question whether the class of poly($n$)-sized formulas (resp. algebraic branching programs) is closed under factoring. We show that given a polynomial $f$ of degree $n^{O(1)}$ and formula (resp. ABP) size $n^{O(\log n)}$ we can find a similar size formula (resp. ABP) factor in randomized poly($n^{\log n}$)-time. Consequently, if determinant requires $n^{\Omega(\log n)}$ size formula, then the same can be said about any of its nonzero multiples. As part of our proofs, we identify a new property of multivariate polynomial factorization. We show that under a random linear transformation $\tau$, $f(\tau\overline{x})$ completely factors via power series roots. Moreover, the factorization adapts well to circuit complexity analysis. This with allRootsNI are the techniques that help us make progress towards the old open problems, supplementing the large body of classical results and concepts in algebraic circuit factorization (eg. Zassenhaus, J.NT 1969, Kaltofen, STOC 1985-7 \& Burgisser, FOCS 2001).Comment: 33 Pages, No figure

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.

OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy. METHODS: Method and outcome classification of the study complied with WHO guidelines. Children 6-59 months with uncomplicated malaria were followed-up for 28 days. PCR genotyping was used to distinguish recrudescence from reinfection. Reinfections were reclassified as cured. RESULTS: Of 172 children who were referred to the study clinic, 126 satisfied inclusion criteria and were enrolled. No early treatment failures were reported. The day 14, efficacy was 98.2% (95% CI: 93.8-99.8). Of 65 recurrent parasitaemias analysed by PCR, 17 were recrudescences. The PCR-adjusted day 28 efficacy was 84.5% (95% CI: 76.4-90.7). All true failures occurred in the last 8 days of follow-up. Of 110 children who completed the 28-day follow-up, 54 (49.1%) experienced a novel infection. CONCLUSION: The efficacy of this combination was disappointing. The high reinfection rate suggested little prophylactic effect. In Kailahun a more efficacious combination might be necessary in the future. The efficacy of AS + AQ needs to be monitored in Kailahun and in the other regions of Sierra Leone

Diffractive Dissociation and Eikonalization in High Energy pp and p pˉ {\bar p} Collisions

We show that eikonal corrections imposed on diffraction dissociation processes calculated in the triple Regge limit, produce a radical change in the energy dependence of the predicted cross section. The induced correction is shown to be in general agreement with the new experimental data measured at the Tevatron.Comment: 11 pages LATEX, ( two figures not included obtainable from authors) (TAUP 2066-93 and FERMILAB PUB 93/ T