Geodesic motions in extraordinary string geometry

The geodesic properties of the extraordinary vacuum string solution in (4+1) dimensions are analyzed by using Hamilton-Jacobi method. The geodesic motions show distinct properties from those of the static one. Especially, any freely falling particle can not arrive at the horizon or singularity. There exist stable null circular orbits and bouncing timelike and null geodesics. To get into the horizon {or singularity}, a particle need to follow a non-geodesic trajectory. We also analyze the orbit precession to show that the precession angle has distinct features for each geometry such as naked singularity, black string, and wormhole.Comment: 15 pages, 11 figure

Particle Probe of Horava-Lifshitz Gravity

Kehagias-Sfetsos black hole in Ho\v{r}ava-Lifshitz gravity is probed through particle geodesics. Gravitational force of KS black hole becomes weaker than that of Schwarzschild around horizon and interior space. Particles can be always scattered or trapped in new closed orbits, unlike those falling forever in Schwarzschild black. The properties of null and timelike geodesics are classified with values of coupling constants. The precession rates of the orbits are evaluated. The time trajectories are also classified under different values of coupling constants for both null and timelike geodesics. Physical phenomena that may be observable are discussed.Comment: 10 pages, 8 figure

The Baryonic Phase in Holographic Descriptions of the QCD Phase Diagram

We study holographic models of the QCD temperature-chemical potential phase diagram based on the D3/D7 system with chiral symmetry breaking. The baryonic phase may be included through linked D5-D7 systems. In a previous analysis of a model with a running gauge coupling a baryonic phase was shown to exist to arbitrarily large chemical potential. Here we explore this phase in a more generic phenomenological setting with a step function dilaton profile. The change in dilaton generates a linear confining $\bar{q}q$ potential and opposes the screening effect of temperature. We show that the persistence of the baryonic phase depends on the step size and that QCD-like phase diagrams can be described. The baryonic phase's existence is qualitatively linked to the existence of confinement in Wilson loop computations in the background.Comment: 21 pages, 7 figure

Semiclassical strings in AdS(3) X S^2

In this paper, we investigate the semiclassical strings in AdS(3)XS^2, in which the string configuration of AdS(3) is classified to three cases depending on the parameters. Each of these has a different anomalous dimension proportional to logS, S^(1/3) and S, where S is a angular momentum on AdS(3). Further we generalize the dispersion relations for various string configuration on AdS(3)XS^2.Comment: 15 pages, added reference

Towards a Holographic Model of the QCD Phase Diagram

We describe the temperature-chemical potential phase diagrams of holographic models of a range of strongly coupled gauge theories that display chiral symmetry breaking/restoration transitions. The models are based on the D3/probe-D7 system but with a phenomenologically chosen running coupling/dilaton profile. We realize chiral phase transitions with either temperature or density that are first or second order by changing the dilaton profile. Although the models are only caricatures of QCD they show that holographic models can capture many aspects of the QCD phase diagram and hint at the dependence on the running coupling.Comment: 11 pages, 9 figures, v2: minor corrections, Invited contribution to an AdS/CFT edition of Journal of Physics

Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma

Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and human epidermal growth factor receptor 2 (HER2) have been considered as potential therapeutic targets in cholangiocarcinoma, but no studies have yet clarified the clinicopathological or prognostic significance of these molecules. Immunohistochemical expression of these molecules was assessed retrospectively in 236 cases of cholangiocarcinoma, as well as associations between the expression of these molecules and clinicopathological factors or clinical outcome. The proportions of positive cases for EGFR, VEGF, and HER2 overexpression were 27.4, 53.8, and 0.9% in intrahepatic cholangiocarcinoma (IHCC), and 19.2, 59.2, and 8.5% in extrahepatic cholangiocarcinoma (EHCC), respectively. Clinicopathologically, EGFR overexpression was associated with macroscopic type (P=0.0120), lymph node metastasis (P=0.0006), tumour stage (P=0.0424), lymphatic vessel invasion (P=0.0371), and perineural invasion (P=0.0459) in EHCC, and VEGF overexpression with intrahepatic metastasis (P=0.0224) in IHCC. Multivariate analysis showed that EGFR expression was a significant prognostic factor (hazard ratio (HR), 2.67; 95% confidence interval (CI), 1.52–4.69; P=0.0006) and also a risk factor for tumour recurrence (HR, 1.89; 95% CI, 1.05–3.39, P=0.0335) in IHCC. These results suggest that EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma

Simulation of dilated heart failure with continuous flow circulatory support

Lumped parameter models have been employed for decades to simulate important hemodynamic couplings between a left ventricular assist device (LVAD) and the native circulation. However, these studies seldom consider the pathological descending limb of the Frank-Starling response of the overloaded ventricle. This study introduces a dilated heart failure model featuring a unimodal end systolic pressure-volume relationship (ESPVR) to address this critical shortcoming. The resulting hemodynamic response to mechanical circulatory support are illustrated through numerical simulations of a rotodynamic, continuous flow ventricular assist device (cfVAD) coupled to systemic and pulmonary circulations with baroreflex control. The model further incorporated septal interaction to capture the influence of left ventricular (LV) unloading on right ventricular function. Four heart failure conditions were simulated (LV and bi-ventricular failure with/ without pulmonary hypertension) in addition to normal baseline. Several metrics of LV function, including cardiac output and stroke work, exhibited a unimodal response whereby initial unloading improved function, and further unloading depleted preload reserve thereby reducing ventricular output. The concept of extremal loading was introduced to reflect the loading condition in which the intrinsic LV stroke work is maximized. Simulation of bi-ventricular failure with pulmonary hypertension revealed inadequacy of LV support alone. These simulations motivate the implementation of an extremum tracking feedback controller to potentially optimize ventricular recovery. © 2014 Wang et al

Yolk utilization and growth during the early larval life of the Silver Perch, Bidyanus bidyanus (Mitchell, 1838)

The aim of this research was to investigate the yolk sac and oil globule utilization by silver perch (Bidyanus bidyanus) larvae produced from domesticated broodfish. The larvae were kept unfed in the holding tank, sampled, and investigated by image analysis software to determine various characteristics, such as the diameters of ova, water-hardened eggs, yolk-sac, oil globules, and the total length of larvae. The research illustrated that, with the exception of oil globule diameter, all other morphometric parameters were significantly lower (P < 0.05) when compared to the larvae from the wild broodfish. The yolk sac was completely absorbed at 96 h post-hatching (hph) and the oil globule was visible until 240 hph. The larvae exhibited predatory movements and tried to catch rotifer at 4 days post hatching (dph). However, the onset of feeding took place at 5 dph, while 100% of feeding occurred at 6 dph. During the first 96 h (h), larvae grew significantly faster than the next 144 h. Larvae encountered low mortalities (<10%) during the first 96 hph, before increasing significantly in the next 24 h and no unfed larvae survived post 240 h. The results also suggested that the exogenous feed should be available at 96 hph, which is well after the yolk sac is completely depleted. In addition, although most of eggs and larval performance from domesticated broodfish were inferior compared to the wild one, it has larger oil globule that could make longer of its mixed feeding period and therefore could have better in viability