847 research outputs found
Juror Perceptions of Eyewitness Identification Evidence
Jurors rely on eyewitness testimony in deciding a defendantâs guilt or innocence. Archival analyses of hundreds of post-conviction DNA exonerations have identified eyewitness misidentification as the highest individual factor contributing to wrongful convictions (Innocence Project, 2014). Internationally, criminal justice systems have employed procedural safeguards (PSs) to educate juries on factors affecting eyewitness identification accuracy. Two such safeguards include the introduction of eyewitness expert testimony during trial proceedings and the reading of cautionary instructions by a presiding judge. In an independent factorial design, this research sought to examine the effects of a model judicial caution drafted by the Ontario Judicial Council (2012) and eyewitness expert testimony on jurors. Viewing court transcripts surrounding a fictional robbery case, jurors were presented with independently varied evidence of eyewitness testimony (low confidence vs. high confidence) and photoarray lineups (no lineup vs. unbiased lineup vs. biased lineup). Numerous juror perceptions were measured, including verdicts, eyewitness credibility, defence case strength, and understanding of the trial. Results indicated that jurors were not unduly influenced by eyewitness confidence or expert testimony. Jurors were more likely to convict the defendant when the eyewitness made an identification from an unbiased lineup compared to a biased lineup. While jurors were able to detect foil bias, evidence of juror confusion was found with respect to lineup fairness ratings from jurors exposed to the judicial caution. Results are summarized and discussed in view of current Canadian trial proceedings
Gene therapy and editing: Novel potential treatments for neuronal channelopathies.
Pharmaceutical treatment can be inadequate, non-effective, or intolerable for many people suffering from a neuronal channelopathy. Development of novel treatment options, particularly those with the potential to be curative is warranted. Gene therapy approaches can permit cell-specific modification of neuronal and circuit excitability and have been investigated experimentally as a therapy for numerous neurological disorders, with clinical trials for several neurodegenerative diseases ongoing. Channelopathies can arise from a wide array of gene mutations; however they usually result in periods of aberrant network excitability. Therefore gene therapy strategies based on up or downregulation of genes that modulate neuronal excitability may be effective therapy for a wide range of neuronal channelopathies. As many channelopathies are paroxysmal in nature, optogenetic or chemogenetic approaches may be well suited to treat the symptoms of these diseases. Recent advances in gene-editing technologies such as the CRISPR-Cas9 system could in the future result in entirely novel treatment for a channelopathy by repairing disease-causing channel mutations at the germline level. As the brain may develop and wire abnormally as a consequence of an inherited or de novo channelopathy, the choice of optimal gene therapy or gene editing strategy will depend on the time of intervention (germline, neonatal or adult)
Students\u27 use of personal technology in the classroom: analyzing the perceptions of the digital generation
Faculty frequently express concerns about studentsâ personal use of information
and communication technologies in todayâs university classrooms. As a requirement
of a graduate research methodology course in a university in Ontario,
Canada, the authors conducted qualitative research to gain an in-depth understanding
of studentsâ perceptions of this issue. Their findings reveal studentsâ
complex considerations about the acceptability of technology use. Their analysis
of the broader contexts of studentsâ use reveals that despite a technological revolution,
university teaching practices have remained largely the same, resulting in
âcultural lagâ within the classroom. While faculty are technically âin chargeâ, students
wield power through course evaluations, surveillance technologies and
Internet postings. Neoliberalism and the corporatisation of the university have
engendered an âentrepreneurial studentâ customer who sees education as a means
to a career. Understanding studentsâ perceptions and their technological, social
and political contexts offers insights into the tensions within todayâs classrooms
Low-Temperature Photoluminescence Spectroscopy of Solvent-Free PCBM Single-Crystals
PCBM ([6,6]-phenyl-C61-butyric acid methyl ester) is a highly soluble C60 derivative that is extensively used in organic solar cells, enabling power conversion efficiencies above 10%. Here we report, for the first time to the best of our knowledge, the photoluminescence of high-quality solvent-free PCBM crystals between room temperature and 4 K. Interestingly, the PL spectra of these crystals become increasingly structured as the temperature is lowered, with extremely well-resolved emission lines (and a minimum line width of âŒ1.3 meV at 1.73 eV). We are able to account for such a structured emission by means of a vibronic coupling model including FranckâCondon, JahnâTeller and HerzbergâTeller effects. Although optical transitions are not formally forbidden from the low-lying excited states of PCBM, the high symmetry of the electronically active fullerene core limits the intensity of the 0â0 transition, such that HerzbergâTeller transitions which borrow intensity from higher-lying states represent a large part of the observed spectrum. Our simulations suggest that the emissive state of PCBM can be considered as a mixture of the T1g and Hg excited states of C60 and hence that the Hg state plays a larger role in the relaxed excited state of PCBM than in that of C60
NASA technology utilization survey on composite materials
NASA and NASA-funded contractor contributions to the field of composite materials are surveyed. Existing and potential non-aerospace applications of the newer composite materials are emphasized. Economic factors for selection of a composite for a particular application are weight savings, performance (high strength, high elastic modulus, low coefficient of expansion, heat resistance, corrosion resistance,), longer service life, and reduced maintenance. Applications for composites in agriculture, chemical and petrochemical industries, construction, consumer goods, machinery, power generation and distribution, transportation, biomedicine, and safety are presented. With the continuing trend toward further cost reductions, composites warrant consideration in a wide range of non-aerospace applications. Composite materials discussed include filamentary reinforced materials, laminates, multiphase alloys, solid multiphase lubricants, and multiphase ceramics. New processes developed to aid in fabrication of composites are given
Increased luminescence efficiency by synergistic exploitation of lipo/hydrophilic co-solvency and supramolecular design
We use steady-state and time-resolved photoluminescence (PL) spectroscopy to investigate the luminescent properties of a sulfonated poly(diphenylenevinylene) lithium salt (PDV.Li) in water/propanol solutions at different concentrations, with a view to assessing its aggregation behavior. In particular, we compare results from uninsulated PDV.Li and cyclodextrin-threaded PDV.Li polyrotaxane (PDV.LiâÎČ-CD). We find that addition of 1-propanol (â„20 weight%) leads to a significant blue-shift (of âŒ0.20 eV) of the PL spectra, that we assign to suppressed interchain aggregation in PDV.Li solutions, with a concomitant fourfold increase in the fluorescence quantum efficiency (i.e. from 14 to 60%). Surprisingly, a moderate concentration of propanol increases further the luminescence efficiency even for PDV.LiâÎČ-CD, whose supramolecular encapsulation already provides a shield against aggregation. Indeed, addition of propanol reduces the solvent polarity, and therefore helps solubilizing these materials that are still largely aromatic in nature. Interestingly, however, both uninsulated PDV.Li and polyrotaxane solutions exhibit signs of aggregation at high propanol fraction (>70%) with a distinctively weaker coupling than that of interchain states in PDV.Li at high water concentration and in pure water in particular. While we ascribe such behavior to a poor solvation of the polar moieties, we also report a different strength of aggregation for PDV.Li and PDV.LiâÎČ-CD that can be attributed to the presence of the cyclodextrin rings. In PDV.LiâÎČ-CD hydrogen bonding between the cyclodextrin rings may lead to closer packing between the polymer chains. We therefore suggest that a content of propanol between 30 and 70% provides a good balance of hydrophobic and hydrophilic interactions both for PDV.Li and PDV.LiâÎČ-CD
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Integrated motivational interviewing and cognitive behavioural therapy for people with psychosis and comorbid substance misuse: randomised controlled trial
Objectives
To evaluate the effectiveness of integrated motivational interviewing and cognitive behaviour therapy in addition to standard care for patients with psychosis and a co-morbid substance use problem.
Design
Two-centre, open, rater-blind randomised controlled trial
Setting
UK Secondary Care
Participants
327 patients with clinical diagnoses of schizophrenia, schizophreniform or schizoaffective disorder and DSM-IV diagnoses of drug and/or alcohol dependence or abuse
Interventions
Participants were randomly allocated to integrated motivational interviewing and cognitive behaviour therapy or standard care. Therapy has two phases. Phase one â âmotivation buildingâ â concerns engaging the patient, then exploring and resolving ambivalence for change in substance use. Phase two ââActionâ â supports and facilitates change using cognitive behavioural approaches. Up to 26 therapy sessions were delivered over one year.
Main outcomes
The primary outcome was death from any cause or admission to hospital in the 12 months after therapy. Secondary outcomes were frequency and amount of substance use (Timeline Followback), readiness to change, perceived negative consequences of use, psychotic symptom ratings, number and duration of relapses, global assessment of functioning and deliberate self harm, at 12 and 24 months, with additional Timeline Followback assessments at 6 and 18 months. Analysis was by intention-to-treat with robust treatment effect estimates.
Results
327 participants were randomised. 326 (99.7%) were assessed on the primary outcome, 246 (75.2%) on main secondary outcomes at 24 months. Regarding the primary outcome, there was no beneficial treatment effect on hospital admissions/ death during follow-up, with 20.2% (33/163) of controls and 23.3% (38/163) of the therapy group deceased or admitted (adjusted odds-ratio 1.16; P= 0.579; 95% confidence interval 0.68 to 1.99). For secondary outcomes there was no treatment effect on frequency of substance use or perceived negative consequences, but a statistically significant effect of therapy on amount used per substance-using day (adjusted odds-ratios: (a) for main substance 1.50; P=0.016; 1.08 to 2.09, (b) all substances 1.48; P=0.017; 1.07 to 2.05). There was a statistically significant treatment effect on readiness to change use at 12 months (adjusted odds-ratio 2.05; P=0.004; 1.26 to 3.31), not maintained at 24 months. There were no treatment effects on assessed clinical outcomes.
Conclusions
Integrated motivational interviewing and cognitive behaviour therapy for people with psychosis and substance misuse does not improve outcome in terms of hospitalisation, symptom outcomes or functioning. It does result in a reduction in amount of substance use which is maintained over the yearâs follow up.
Trial registration
Current Controlled Trials: ISRCTN1440448
Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia - a multi-centre randomised controlled trial
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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