The development of complex verb constructions in British Sign Language

This study focuses on the mapping of events onto verb-argument structures in British Sign Language (BSL). The development of complex sentences in BSL is described in a group of 30 children, aged 3;2–12;0, using data from comprehension measures and elicited sentence production. The findings support two interpretations: firstly, in the mapping of concepts onto language, children acquiring BSL overgeneralize the use of argument structure related to perspective shifting;secondly, these overgeneralizations are predicted by the typological characteristics of the language and modality. Children under age 6;0, in attempting to produce sentences encoded through a perspective shift, begin by breaking down double-verb constructions (AB verbs) into components, producing only the part of the verb phrase which describes the perspective of the patient. There is also a prolonged period of development of non-manual features, with the full structure not seen in its adult form until after 9;0. The errors in the use of AB verbs and the subsequent protracted development of correct usage are explained in terms of the conceptual–linguistic interface

Deaf and hearing children's picture naming Impact of age of acquisition and language modality on representational gesture

Stefanini, Bello, Caselli, Iverson, & Volterra (2009) reported that Italian 24-36 month old children use a high proportion of representational gestures to accompany their spoken responses when labelling pictures. The two studies reported here used the same naming task with (1) typically developing 24-46-month-old hearing children acquiring English and (2) 24-63-month-old deaf children of deaf and hearing parents acquiring British Sign Language (BSL) and spoken English. In Study 1 children scored within the range of correct spoken responses previously reported, but produced very few representational gestures. However, when they did gesture, they expressed the same action meanings as reported in previous research. The action bias was also observed in deaf children of hearing parents in Study 2, who labelled pictures with signs, spoken words and gestures. The deaf group with deaf parents used BSL almost exclusively with few additional gestures. The function of representational gestures in spoken and signed vocabulary development is considered in relation to differences between native and non-native sign language acquisition

Language impairments in sign language: breakthroughs and puzzles

Short Report. Background: Specific Language Impairment (SLI) has previously solely been documented for children acquiring spoken languages despite informal reports of deaf children with possible sign language disorder. Aims: This research evaluates current theories of SLI in light of cases of sign language impairment. Current explanations for SLI include deficits in processing the acoustic signal, phonological short-term memory and grammatical computation. Methods: We report the case of a deaf child deaf exposed to British Sign Language (BSL) from birth with no cognitive or social impairments, with significant developmental deficits in the comprehension and production of BSL grammar but not phonology or vocabulary, based on formal assessment and linguistic analyses of his everyday sign communication in comparison with age matched unimpaired signers. Results: We show that linguistic processing difficulties with BSL verb morphology underlie the child’s poor performance compared with same-age native signers. Conclusions: SLI in children exposed to a soundless language is not explainable by deficits in the auditory processing of the speech signal. The appearance of linguistic impairments in sign and spoken languages in comparable domains provides evidence that some types of SLI involve higher-level problems with the abstract epresentation of rules and grammar

Measurements of Surface Diffusivity and Coarsening During Pulsed Laser Deposition

Pulsed Laser Deposition (PLD) of homoepitaxial SrTiO3 was studied with in-situ x-ray specular reflectivity and surface diffuse x-ray scattering. Unlike prior reflectivity-based studies, these measurements access both the time- and the length-scales of the evolution of the surface morphology during growth. In particular, we show that this technique allows direct measurements of the diffusivity for both inter- and intra-layer transport. Our results explicitly limit the possible role of island break-up, demonstrate the key roles played by nucleation and coarsening in PLD, and place an upper bound on the Ehrlich-Schwoebel (ES) barrier for downhill diffusion

The onset and mastery of spatial language in children acquiring British Sign Language

In the course of language development children must solve arbitrary form-to-meaning mappings, in which semantic components are encoded onto linguistic labels. Because sign languages describe motion and location of entities through iconic movements and placement of the hands in space, child signers may find spatial semantics-to-language mapping easier to learn than child speakers. This hypothesis was tested in two studies: a longitudinal analysis of a native signing child's use of British Sign Language to describe motion and location events between the ages 1–10 and 3–0, and performance of 18 native signing children between the ages of 3–0 and 4–11 on a motion and location sentence comprehension task. The results from both studies argue against a developmental advantage for sign language learners for the acquisition of motion and location forms. Early forms point towards gesture and embodied actions followed by protracted mastery of the use of signs in representational space. The understanding of relative spatial relations continues to be difficult, despite the iconicity of these forms in the language, beyond 5 years of age

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.

Voltage-gated sodium (NaV) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic NaV channel NaChBac have demonstrated that propofol promotes channel activation and accelerates activation-coupled inactivation, but the molecular mechanisms of these effects are unclear. Here, guided by computational docking and molecular dynamics simulations, we predict several propofol-binding sites in NaChBac. We then strategically place small fluorinated probes at these putative binding sites and experimentally quantify the interaction strengths with a fluorinated propofol analogue, 4-fluoropropofol. In vitro and in vivo measurements show that 4-fluoropropofol and propofol have similar effects on NaChBac function and nearly identical anesthetizing effects on tadpole mobility. Using quantitative analysis by 19F-NMR saturation transfer difference spectroscopy, we reveal strong intermolecular cross-relaxation rate constants between 4-fluoropropofol and four different regions of NaChBac, including the activation gate and selectivity filter in the pore, the voltage sensing domain, and the S4-S5 linker. Unlike volatile anesthetics, 4-fluoropropofol does not bind to the extracellular interface of the pore domain. Collectively, our results show that propofol inhibits NaChBac at multiple sites, likely with distinct modes of action. This study provides a molecular basis for understanding the net inhibitory action of propofol on NaV channels. © 2018 Wang et al

The role of two-stage phase formation for the solid-state runaway reaction in Al/Ni reactive multilayers

While extensively studied for heating rates below 1.7 K/s and above 1000 K/s, the solid-state phase transformations in Al/Ni reactive multilayers have not been examined at intermediate heating rates between 100 K/s and 1000 K/s. Combined nanocalorimetry and time-resolved synchrotron x-ray diffraction studies are utilized to address this range of heating rates for multilayers with an overall composition of 10 at. % Ni and a bilayer thickness of 220 nm. It was found that a two-stage phase formation of Al$_{3}$Ni proceeds up to a heating rate of 1000 K/s. The two growth stages occur in the solid-state and are kinetically separated. The activation energy of the first growth stage is determined to be 137 kJ/mol, which agrees well with the literature data at low heating rates. At 1000 K/s, a transition to a runaway reaction is observed. Unusual for metallic multilayers, the reaction proceeds completely in the solid-state which is also known as “solid flame.” Using nanocalorimetry, a critical input power density for ignition of 5.8 x 10$^{4}$ W/cm$^{3}$ was determined. The rapid succession of the two Al$_{3}$Ni formation stages was identified as the underlying mechanism for the self-sustaining reaction

Identifying SLI in deaf children acquiring British Sign Language: Implications for theory and practice

This paper presents the first ever group study of specific language impairment (SLI) in users of sign language. A group of 50 children were referred to the study by teachers and speech and language therapists. Individuals who fitted pre-determined criteria for SLI were then systematically assessed. Here, we describe in detail the performance of 13 signing deaf children aged 5–14 years on normed tests of British Sign Language (BSL) sentence comprehension, repetition of nonsense signs, expressive grammar and narrative skills, alongside tests of non-verbal intelligence and fine motor control. Results show these children to have a significant language delay compared to their peers matched for age and language experience. This impaired development cannot be explained by poor exposure to BSL, or by lower general cognitive, social, or motor abilities. As is the case for SLI in spoken languages, we find heterogeneity within the group in terms of which aspects of language are affected and the severity of the impairment. We discuss the implications of the existence of language impairments in a sign language for theories of SLI and clinical practice

Language against the odds: the learning of British Sign Language by a polyglot savant

In this paper we report on our attempt to teach the polyglot savant Christopher (‘C’ hereinafter) British Sign Language (BSL). BSL presents C with a novel challenge in the use of hand-eye coordination, while at the same time offering him the linguistic ingredients he is obsessed with. Despite his deficits in key areas of intellectual ability, communication skills and visuo-spatial cognition, C has developed a working knowledge of BSL through processes of circumvention, adaptation and invention. As a form of control, we taught BSL to a comparator group of talented second-language learners. We do not discuss this comparison in depth here (see Morgan et al. in preparation) but refer to some of the test scores as a guide to how normal a sign learner C is. Results from formal tests of C's linguistic knowledge, and observational study of his developing communicative ability in BSL, are analysed and described. These results illuminate the structure and use of BSL, highlighting the important role of visuo-spatial cognition in its acquisition and manipulation. Our findings support the assumption that the organisation of knowledge of language is largely modality independent, whereas the exploitation of specific grammatical devices is language and modality dependent. C has attained a certain level of linguistic competence in BSL, and his performance in the language is largely in conformity with his previously established mixed profile of abilities and disabilities