Investigation of Antioxidant Properties of Some 6-(Α-Aminobenzyl) Thiazolo[3,2-B]-1,2,4-Triazole-5-Ol Compounds

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Mean platelet volume as an inflammation marker in active pulmonary tuberculosis

Background: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined. Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated. Results: The MPV was 7.74 ± 1.33/µL in the PTB group and 8.20 ± 1.13/µL in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease. Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable

Mediating role of loneliness and organizational conflict between work overload and turnover intention

20th Congress of the International Ergonomics Association, IEA 2018 -- 26 August 2018 through 30 August 2018 -- 216789The fact that organizations offer employees a positive organizational climate not only increases employees’ happiness levels but also raises the level of creativity of employees. When it is thought that the only way for organizations to survive in a competitive environment is innovative and creative applications, the positive dynamics within the organization once again emerges. This research focuses on negative behaviors such as work overload, loneliness, organizational conflict and turnover intention which affect employees’ creativity and it aims to discover the mediating role of loneliness and organizational conflict between work overload and turnover intention. In the present research, a survey was conducted including 145 service sector employees. To analyze the demographic characteristics of the participants, internal consistency and correlations of scales, SPSS 22.0; and to test the mediating role, SmartPLS 2.0 were used. According to the analysis results; it is determined that between work overload and turnover intention, loneliness and organizational conflict have a mediating role. When all the results are evaluated together, work overload in the organization forces employees to extreme behavior and it is found that employees feel loneliness or conflict, and as a result, their turnover intention increases. Related to this, it is possible to say that the overloaded employees get further away from creativity. © Springer Nature Switzerland AG 2019.2-s2.0-8505181227