The Intimate Life of Dissent: Anthropological Perspectives

The Intimate Life of Dissent examines the meanings and implications of public acts of dissent, drawing on examples from ethnography and history. Acts of dissent are never simply just about abstract principles, but also come at great personal risk to both the dissidents and to those close to them. Dissent is, therefore, embedded in deep, complex and sometimes contradictory intimate relations. This book puts acts of high principle back into the personal relations out of which they emerge and take effect, raising new questions about the relationship between intimacy and political commitment. It does so through an introduction and eight individual chapters, drawing on examples including Sri Lankan leftists, Soviet dissidents, Tibetan exiles, Kurdish prisoners, British pacifists, Indonesian student activists and Jewish peace activists. The Intimate Life of Dissent will be of interest to postgraduate students and researchers of anthropology, history, political theory and sociology. Written in a clear and accessible style, it is also suitable for teaching introductory undergraduate courses on political anthropology

Measurement and analysis of needle penetration forces in industrial high-speed sewing machine

The industrial manufacturing of sewn products has always been one of the critical processes of the textile chain concerning quality assurance. Assuring the appropriate set-up and operation of all the machines, and thus the final seam quality, is a very complex task. Traditionally, this task is accomplished through empirical methods, with the machine setting and quality control relying on the skills of operators and technicians. This work presents an approach to a more knowledge-based and integrated process planning and control. A system was developed to measure and analyze the most important mechanical effects occurring during high-speed sewing. The paper will focus mainly on the measurement and evaluation of needle penetration and withdrawal force. After an overview of the system, the most important experimental results obtained in a series of experiments will be described

End of organised atheism. The genealogy of the law on freedom of conscience and its conceptual effects in Russia

In the current climate of the perceived alliance between the Russian Orthodox Church and the state, atheist activists in Moscow share a sense of juridical marginality that they seek to mitigate through claims to equal rights between believers and atheists under the Russian law on freedom of conscience. In their demands for their constitutional rights, including the right to political critique, atheist activists come across as figures of dissent at risk of the state's persecution. Their experiences constitute a remarkable (and unexamined in anthropology) reversal of political and ideological primacy of state-sponsored atheism during the Soviet days. To illuminate the legal context of the atheists’ current predicament, the article traces an alternative genealogy of the Russian law on freedom of conscience from the inception of the Soviet state through the law's post-Soviet reforms. The article shows that the legal reforms have paved the way for practical changes to the privileged legal status of organized atheism and brought about implicit conceptual effects that sideline the Soviet meaning of freedom of conscience as freedom from religion and obscure historical references to conscience as an atheist tenet of Soviet ethics

Automatic detection of airborne pollen: an overview

Pollen monitoring has traditionally been carried out using manual methods frst developed in the early 1950s. Although this technique has been recently standardised, it sufers from several drawbacks, notably data usually only being available with a delay of 3–9 days and usually delivered at a daily resolution. Several automatic instruments have come on to the market over the past few years, with more new devices also under development. This paper provides a comprehensive overview of all available and developing automatic instruments, how they measure, how they identify airborne pollen, what impacts measurement quality, as well as what potential there is for further advancement in the feld of bioaerosol monitoring.</p

Computational tools for splicing defect prediction in breast/ovarian cancer genes: how efficient are they at predicting RNA alterations?

In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome. A study divided into two stages was used to evaluate SSF-like, MaxEntScan, NNSplice, HSF, SPANR, and dbscSNV tools. A discovery dataset of 99 variants with unequivocal results of RNA in vitro studies, located in the 10 exonic and 20 intronic nucleotides adjacent to exon-intron boundaries of BRCA1, BRCA2, MLH1, MSH2, MSH6, PMS2, ATM, BRIP1, CDH1, PALB2, PTEN, RAD51D, STK11, and TP53, was collected from four Spanish cancer genetic laboratories. The best stand-alone predictors or combinations were validated with a set of 346 variants in the same genes with clear splicing outcomes reported in the literature. Sensitivity, specificity, accuracy, negative predictive value (NPV) and Mathews Coefficient Correlation (MCC) scores were used to measure the performance. The discovery stage showed that HSF and SSF-like were the most accurate for variants at the donor and acceptor region, respectively. The further combination analysis revealed that HSF, HSF+SSF-like or HSF+SSF-like+MES achieved a high performance for predicting the disruption of donor sites, and SSF-like or a sequential combination of MES and SSF-like for predicting disruption of acceptor sites. The performance confirmation of these last results with the validation dataset, indicated that the highest sensitivity, accuracy, and NPV (99.44%, 99.44%, and 96.88, respectively) were attained with HSF+SSF-like or HSF+SSF-like+MES for donor sites and SSF-like (92.63%, 92.65%, and 84.44, respectively) for acceptor sites. We provide recommendations for combining algorithms to conduct in silico splicing analysis that achieved a high performance. The high NPV obtained allows to select the variants in which the study by in vitro RNA analysis is mandatory against those with a negligible probability of being spliceogenic. Our study also shows that the performance of each specific predictor varies depending on whether the natural splicing sites are donors or acceptors

Performative failure among Islamic mystics in urban Macedonia

Based on the field research among practitioners of mystical Islam in urban Macedonia, this thesis examines a modality of failure to perform one's religion. Having initiated a reform of their ancestral religious tradition, these practitioners experienced a peculiar dissatisfaction with their own accomplishments as Sufi saints. Self-critically, aspirants observed that their flair to perform rituals and to commit to spiritual exercises and techniques of ethical self-fashioning fell far short of the prototypical examples of the Prophet Muhammed and the ancient Sufis. Theological books about the lives of these figures captured people's intellectual imagination. These texts did not, however, yield concrete performative technologies that would enable aspirants to succeed in replicating the spiritual ontologies of the dead Muslim saints in the contemporary nation-state of Macedonia. People were convinced that their spiritual advancement depended on the enactment of theological propositions in formal rituals and interpersonal relations, yet they felt hindered by not knowing the 'correct' experiential methods of ritual training and ethical self-work (autopoesis) and by their physical disengagement from religious practices. Aspirants described themselves as incomplete mystics and proclaimed that they had failed to become intensely religious beings. Through detailed ethnography, this thesis explores people's experiences of performative failure and illuminates the themes of theological learning, ritual founderings, unavailability of bodies for rituals and religious training, and the search for the lost method of self-transformation into a saint. Performative failure is defined as a postponement of achievement under infelicitous historical conditions. Drawing on a variety of anthropological theories and comparative ethnographic cases, this thesis aims to contribute new ethnographic material to the anthropology of religion and to articulate critical insights into the difficulties of turning theology into performances. Furthermore, the thesis examines the possibility of failure that hovers over people's reflexive efforts to actualize their ambitions and desires and argues that failure is a productive analytical concept for the understanding of aspirations and barriers to excellence

Assessing combining Abilities And breeding vAlue of dry peA genotypes

Abstract GantneR, R., t. cupic, M. Stjepanovic, G. DRezneR and G. Bukvic, 2014. assessing combining abilities and breeding value of dry pea genotypes. Bulg. J. Agric. Sci., aim of the research was to assess a breeding value of 6 parental genotypes of dry pea and their F 1 progeny produced in a diallel fashion. the traits enquired were plant height, count of nodes till the 1 st podded node, mass of 1000 seeds and grain yield per plant. parental breeding values were assessed by means of their Gca effects, whilst the F 1 crossess was assessed upon their exhibited per-se values. all the results were discussed with respect to the breeding goals. there were distinguished the most promising parents and cross-combinations for the improved RiLs derivation

Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.

The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) is required for the initiation of essentially all macroautophagic processes. PI3KC3-C1 consists of the lipid kinase catalytic subunit VPS34, the VPS15 scaffold, and the regulatory BECN1 and ATG14 subunits. The VPS34 catalytic domain and BECN1:ATG14 subcomplex do not touch, and it is unclear how allosteric signals are transmitted to VPS34. We used EM and crosslinking mass spectrometry to dissect five conformational substates of the complex, including one in which the VPS34 catalytic domain is dislodged from the complex but remains tethered by an intrinsically disordered linker. A "leashed" construct prevented dislodging without interfering with the other conformations, blocked enzyme activity in&nbsp;vitro, and blocked autophagy induction in yeast cells. This pinpoints the dislodging and tethering of the VPS34 catalytic domain, and its regulation by VPS15, as a master allosteric switch in autophagy induction

Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex.

The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex and mechanisms that regulate VPS34 activity at the membrane