323 research outputs found
Design and Implementation of a Measurement-Based Policy-Driven Resource Management Framework For Converged Networks
This paper presents the design and implementation of a measurement-based QoS
and resource management framework, CNQF (Converged Networks QoS Management
Framework). CNQF is designed to provide unified, scalable QoS control and
resource management through the use of a policy-based network management
paradigm. It achieves this via distributed functional entities that are
deployed to co-ordinate the resources of the transport network through
centralized policy-driven decisions supported by measurement-based control
architecture. We present the CNQF architecture, implementation of the prototype
and validation of various inbuilt QoS control mechanisms using real traffic
flows on a Linux-based experimental test bed.Comment: in Ictact Journal On Communication Technology: Special Issue On Next
Generation Wireless Networks And Applications, June 2011, Volume 2, Issue 2,
Issn: 2229-6948(Online
An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction & muscle atrophy. The carboxyl-terminal prion-like domain of TDP-43 can aggregate in vitro into toxic β-sheet rich amyloid-like structures. So far, treatment options for ALS are very limited and Riluzole, which targets glutamate receptors, is the only but highly ineffective drug. Therefore, great interest exists in developing molecules for ALS treatment. Here, we have examined certain derivatives of acridine containing same side chains at position 4 & 5, for inhibitory potential against TDP-43 aggregation. Among several acridine derivatives examined, AIM4, which contains polar carboxyl groups in the side arms, significantly reduces TDP-43-YFP aggregation in the powerful yeast model cell and also abolishes in vitro amyloid-like aggregation of carboxyl terminal domain of TDP-43, as observed by AFM imaging. Thus, AIM4 can be a lead molecule potentiating further therapeutic research for ALS
Characterization of Leptospira borgpetersenii isolates from field rats (Rattus norvegicus) by 16S rRNA and lipL32 gene sequencing
The Social Relations Approach, empowerment and women factory workers in Malaysia
This article discusses the empowerment of women factory workers in Malaysia through the lens of Kabeer’s Social Relations Approach. The approach offers an institutional analysis of how gender inequality is produced and calls for the overall terms of exchange and cooperation to be shifted in women’s favour. Its application shows that Malaysian women factory workers face significant challenges, due to the character of institutions, and women’s difficulties in adopting and internalising the notion of ‘empowerment’
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