The effect of cocaine on gastric mucosal PGE2, LTC4 and ulcerations

The association between cocaine use and acute gastroduodenal perforation is known. The effect of cocaine and stress on gastric mucosal ulceration and the levels of prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) was studied in 40 Sprague–Dawley rats. Controls received intraperitoneal (i.p.) saline, ten received i.p. cocaine (35 mg/kg), ten were stressed by the cold restraint method, and ten had i.p. cocaine and stress. Cocaine alone did not induce ulceration, but decreased PGE2 levels. Stress alone caused ulceration, but was not associated with a change in either PGE2 or LTC4 levels. When combined with stress, however, cocaine caused a three-fold increase in ulceration and a significant increase in PGE2 and LTC4 levels. Stress may predispose the cocaine addict to loss of gastroduodenal mucosal integrity, which is related to an imbalance of PGE2 and LTC4 synthesis

NSLS-II INJECTION STRAIGHT DIAGNOSTICS

The ultra-bright light source being developed by the NSLS-II project will utilize top-up injection and fine tuning of the injection process is mandatory. In this paper we present the diagnostics installed in the injection straight. Its use for commissioning and tuning of the injection cycle is also described. The NSLS-II storage ring will utilize a 9.3 meter long injection straight section shown in Fig. 1. Injection will be preformed with two septa (one pulsed, one DC) and four kickers. The stored beam will be shifted towards the pulsed septum up to IS mm and the nominal distance between centers of the injected and the bumped beam is 9.5mm. The NSLS-II beam position monitors will have turn-by-turn and first-turn capabilities and will be used for the commissioning and tuning the injection process. However, there are three additional BPMs and two beam intercepting OTR screens (flags) installed in the injection straight

MODULATION OF LOW ENERGY BEAM TO GENERATE PREDEFINED BUNCH TRAINS FOR THE NSLS-II TOP-OFF INJECTION*

Abstract The NSLS II linac will produce a bunch train, 80-150 bunches long with 2 ns bunch spacing. Having the ability to tailor the bunch train can lead to the smaller bunch to bunch charge variation in the storage ring. A stripline is planned to integrate into the linac baseline to achieve this tailoring. The stripline must have a fast field rise and fall time to tailor each bunch. The beam dynamics is minimally affected by including the extra space for the stripline. This paper discusses the linac beam dynamics with stripline, and the optimal design of the stripline

Injection Straight Pulsed Magnet Error Tolerance Study for Top-Off Injection

NSLS II is designed to work in top-off injection mode. The injection straight includes a septum and four fast kicker magnets. The pulsed magnet errors will excite a betatron oscillation. This paper gives the formulas of each error contribution to the oscillation amplitude at various source points in the ring. These are compared with simulation results. Based on the simple formulas, we can specify the error tolerances on the pulsed magnets with the goal to minimize the injection transient and scale it to similar machines. The NSLS-II is a 3 GeV third generation synchrotron light source under construction at Brookhaven National Laboratory. Due to its short lifetime, NSLS-II storage ring requires the top-off injection (once per minute) during which the stored beam orbit is highly desired as transparent. But the errors, from the SR pulsed magnets at the injection straight - kickers (non-closed injection bump) and pulsed septum (time-dependent stray field), excite a stored beam betatron oscillation. The magnitude of the perturbation can be large disturning some of the user experiments. In 2010 injection straight review, based on the experts experiences in ALS, DIAMOND, SLS and SPEAR, we came to the conclusion that the acceptable oscillation amplitude at the long straight is set as 100 {micro}m (i.e. 0.7 {sigma}x) in horizontal plane and 12 {micro}m, 2.5 {sigma}y, in vertical plane for NSLS II. This paper gives the analysis estimate of the different error source tolerance from the pulse magnets and scales it to our requirements. The result is compared with simulation

Microbunching and Beam Break Up in DUV FEL Accelerator

We present the results of electron beam longitudinal modulation studies in the DUV-FEL accelerator. For bunch length determination we used the 'zero-phasing' method, based on a measurement of the chirped electron bunch energy spectra. The measurements revealed a spiky structure in the longitudinal phase space [1]. A model based on space charge effect is considered [2] to explain of the obtained phenomena. The analysis of the energy spectra has shown a sensitivity of the structure to the electron beam peak current, energy and longitudinal non-uniformity of the RF gun drive laser. Analytical calculations have demonstrated a qualitative agreement with experimental observations. Several experiments have been made to compare with theory; measured results are reviewed in this paper. The obtained effect is briefly discussed in relation to high brightness accelerators

Short pulse generation by laser slicing at NSLSII

We discuss an upgrade R&D project for NSLSII to generate sub-pico-second short x-ray pulses using laser slicing. We discuss its basic parameters and present a specific example for a viable design and its performance. Since the installation of the laser slicing system into the storage ring will break the symmetry of the lattice, we demonstrate it is possible to recover the dynamical aperture to the original design goal of the ring. There is a rapid growth of ultrafast user community interested in science using sub-pico-second x-ray pulses. In BNL's Short Pulse Workshop, the discussion from users shows clearly the need for a sub-pico-second pulse source using laser slicing method. In the proposal submitted following this workshop, NSLS team proposed both hard x-ray and soft x-ray beamlines using laser slicing pulses. Hence there is clearly a need to consider the R&D efforts of laser slicing short pulse generation at NSLSII to meet these goals

Conceptual Design of the NSLS-II Injection System.

We present the conceptual design of the NSLS-II injection system [1,2]. The injection system consists of a low-energy linac, booster and transport lines. We review two different injection system configurations; a booster located in the storage ring tunnel and a booster housed in a separate building. We briefly discuss main parameters and layout of the injection system components

NSLS-II Beam Diagnostics Overview

A new 3rd generation light source (NSLS-II) is in the early stages of construction at Brookhaven National Laboratory. The NSLS-II facility will provide ultra high brightness and flux with exceptional beam stability. It presents several challenges for diagnostics and instrumentation, related to the extremely small emittance. In this paper, we present an overview of all planned instrumentation systems, results from research and development activities; and then focus on other challenging aspects

Status of NSLS-II booster

The National Synchrotron Light Source II is a third generation light source under construction at Brookhaven National Laboratory. The project includes a highly optimized 3 GeV electron storage ring, linac pre-injector and full-energy booster-synchrotron. Budker Institute of Nuclear Physics builds booster for NSLS-II. The booster should accelerate the electron beam continuously and reliably from minimal 170 MeV injection energy to maximal energy of 3.15 GeV and average beam current of 20 mA. The booster shall be capable of multi-bunch and single bunch operation. This paper summarizes the status of NSLS-II booster.Национальный источник синхротронного излучения II является синхротроном третьего поколения, созданным в Брукхевенской национальной лаборатории. Проект включает: высокооптимизированное накопительное кольцо на 3 ГэВ, линейный ускоритель и бустерный синхротрон на полную энергию. Институт ядерной физики им. Г.И. Будкера создает бустер для NSLS-II. Бустер должен надежно и непрерывно ускорять пучок электронов от минимальной энергии инжекции 170 МэВ до максимальной энергии 3,15 ГэВ с током пучка 20 мА. Бустер должен быть способен работать в односгустковом и многосгустковом режимах. Эта статья суммирует состояние дел по бустеру для NSLS-II.Національне джерело синхротронного випромінювання II є синхротроном третього покоління, створеним у Брукхевенській національній лабораторії. Проект включає: високооптимізоване накопичувальне кільце на 3 ГеВ, лінійний прискорювач і бустерний синхротрон на повну енергію. Інститут ядерної фізики ім. Г.І. Будкера створює бустер для NSLS-II. Бустер повинен надійно і безперервно прискорювати пучок електронів від мінімальної енергії інжекції 170 МеВ до максимальної енергії 3,15 ГеВ зі струмом пучка 20 мА. Бустер повинен бути здатний працювати в односгустковому і багатосгустковому режимах. Ця стаття підсумовує стан справ по бустеру для NSLS-II