81 research outputs found
Pulmonary stretch receptor activity during partial liquid ventilation in cats with healthy lungs
Aim: To study whether pulmonary stretch receptor (PSR) activity in mechanically ventilated young cats with healthy lungs during partial liquid ventilation (PLV) is different from that during gas ventilation (GV). Methods: In 10 young cats (4.4 +/- 0.4 months, 2.3 +/- 0.3 kg; mean B SD), PSR instantaneous impulse frequency (PSR f(imp)) was recorded from single fibres in the vagal nerve during GV and PLV with perfluorocarbon (30 ml/kg) at increasing positive inspiratory pressures (PIP; 1.2, 1.8, 2.2 and 2.7 kPa), and at a positive end-expiratory pressure of 0.5 kPa. Results: All PSRs studied during GV maintained their phasic character with increased impulse frequency during inspiration during PLV. Peak PSR fimp was lower at PIP 1.2 kPa (p < 0.05) and at PIP 2.7 kPa (p = 0.10) during PLV than during GV, giving a lower number of PSR impulses at these two settings during PLV (p < 0.05). Conclusion: The phasic character of PSR activity is similar during GV and PLV. PSR activity is not higher during PLV than during GV in cats with healthy lungs, indicating no extensive stretching of the lung during PLV. Copyright (C) 2004 S. Karger AG, Basel
Inhaled nitric oxide therapy in neonates and children: reaching a European consensus
Inhaled nitric oxide (iNO) was first used in neonatal practice in 1992 and has subsequently been used extensively in the management of neonates and children with cardiorespiratory failure. This paper assesses evidence for the use of iNO in this population as presented to a consensus meeting jointly organised by the European Society of Paediatric and Neonatal Intensive Care, the European Society of Paediatric Research and the European Society of Neonatology. Consensus Guidelines on the Use of iNO in Neonates and Children were produced following discussion of the evidence at the consensus meeting
Greater body mass index is related to greater self-identified cold tolerance and greater insensible body mass loss
AFM study of morphology and mechanical properties of a chimeric 2 spider silk and bone sialoprotein protein for bone regeneration
Atomic force microscopy (AFM) was used to assess a
new chimeric protein consisting of a fusion protein of the consensus
repeat for Nephila clavipes spider dragline protein and bone sialoprotein
(6merĂŸBSP). The elastic modulus of this protein in film
form was assessed through force curves, and film surface roughness
was also determined. The results showed a significant difference
among the elastic modulus of the chimeric silk protein, 6merĂŸBSP,
and control films consisting of only the silk component (6mer). The
behavior of the 6merĂŸBSP and 6mer proteins in aqueous solution in
the presence of calcium (Ca) ions was also assessed to determine
interactions between the inorganic and organic components related
to bone interactions, anchoring, and biomaterial network formation.
The results demonstrated the formation of protein networks in the
presence of Ca2ĂŸ ions, characteristics that may be important in the
context of controlling materials assembly and properties related to
bone formation with this new chimeric silk-BSP protein.Silvia Games thanks the Foundation for Science and Technology (FCT) for supporting her Ph.D. grant, SFRH/BD/28603/2006. This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283), the Chimera project (PTDC/EBB-EBI/109093/2008) funded by the FCT agency, the NIH (P41 EB002520) Tissue Engineering Resource Center, and the NIH (EB003210 and DE017207)
Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets
Reduced polarity and improved dispersion of microfibrillated cellulose in poly(lactic-acid) provided by residual lignin and hemicellulose
Application of Colloid Probe Atomic Force Microscopy to the Adhesion of Thin Films of Viscous and Viscoelastic Silicone Fluids
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