An approach for computing AS/R systems travel times in a class-based storage configuration

This study provides an approach to compute the travel time for AS/R systems in a class-based storage environment. A regression analysis is completed in order to define the importance of the key predictors taken into account and to propose a formulation of travel times. The results show the reliability of the model and allow to evaluate the travel time through the identification of a complete list of predictors. The proposed approach supports managers in theex-ante definition of travel times for a warehouse. A correct evaluation of travel times enables a better monitoring of the performance of warehouse operations and can support practitioners in the choice of the configuration not only in terms of kind of cycle, but also from a policy assignment perspective. From a theoretical point of view, this work can be considered as an attempt to refine the existing methods to compute travel times

Guidelines for a common port noise impact assessment: the ANCHOR LIFE project

The paper reports the main contents of the guidelines developed in the framework of the project ANCHOR, acronym of Advanced Noise Control strategies in HarbOuR, which is a European Project funded as part of the announcement Life 2017. The guidelines represent an updated version of those elaborated in the NoMEPorts project named 'Good Practice Guide on Port Area Noise Mapping and Management'; the aim is to define a common approach in port noise monitoring and assessment, considering the outcomes of previous EU funded projects and the algorithms defined by the European Directive 2015/996, in order to produce Port Noise Impact Assessments to be included in ports Environmental Management Systems (EMS). The procedures described in the guidelines will guide professionals in organizing and managing geographical data, in characterizing noise sources and defining, for each of them, the correct noise emission power level, in evaluating noise propagation and people exposure to noise and, finally, in selecting the most efficient mitigation action by means of a cost benefit analysis. Moreover, the paper reports the results of a comparison between noise mapping outcomes obtained using the new noise mapping algorithms defined by the 2015/996 Directive and the old 2002/49/EC Annex II ones; especially at long distances from the source the differences between the two methodologies are not negligible

Airborne Sound Power Levels and Spectra of Noise Sources in Port Areas

Airborne port noise has historically suffered from a lack of regulatory assessment compared to other transport infrastructures. This has led to several complaints from citizens living in the urban areas surrounding ports, which is a very common situation, especially in countries facing the Mediterranean sea. Only in relatively recent years has an effort been made to improve this situation, which has resulted in a call for and financing of numerous international cooperation research projects, within the framework of programs such as EU FP7, H2020, ENPI-CBC MED, LIFE, and INTERREG. These projects dealt with issues and aspects of port noise, which is an intrinsically tangled problem, since several authorities and companies operate within the borders of ports, and several different noise sources are present at the same time. In addition, ship classification societies have recently recognized the problem and nowadays are developing procedures and voluntary notations to assess the airborne noise emission from marine vessels. The present work summarizes the recent results of research regarding port noise sources in order to provide a comprehensive database of sources that can be easily used, for example, as an input to the noise mapping phase, and can subsequently prevent citizens' exposure to noise

Source characterization guidelines for noise mapping of port areas

Maritime transport for both passengers and freight is continuously increasing and, consequently, the global attention toward its sustainability is growing. Ships offer advantages in terms of environmental impact compared to other transportation systems but the increasing traffic volume is expected to increase pollutants. Noise produced in port areas has been neglected for too long, until the INTERREG Maritime programme Italy-France 2014\u20132020 has brought to light how citizen complaints are emerging for some of the main ports in the Mediterranean. However, port noise prevention and management is difficult as knowledge on specific sources is very limited in the literature. Furthermore, on field measurements are difficult to be performed given the complexity of the port area, where multiple types of sound emitters mix and confuse each other. Noise maps represent the first important step in order to align ports to the requirements set by the Environmental Noise Directive to the transportation infrastructures. Once computed, they are an excellent tool supporting port management towards the reduction of citizens\u2019 noise exposure while ensuring traffic growth. The present paper reports a guideline for the characterization of noise sources needed as inputs for the noise maps, as developed in the framework of the INTERREG Maritime programme Italy-France 2014\u20132020. On the basis of the current state of the art, a procedure has been elaborated for different categories of noise sources acting in port, ranging from stationary to moving ships, from mooring operations to loading/unloading operations, from industrial activities to road and railway traffic

Detection of influenza A(H1N1)pdm09 virus in a patient travelling from Shanghai to Italy in July 2018: An uncommon clinical presentation in a non-seasonal period

Influenza is one of the most common infectious diseases in travellers, especially in those returning from subtropical and tropical regions. In late June 2018 an influenza A(H1N1)pdm09 virus infection was diagnosed in a 36-years-old man, returned from a travel in Shanghai and hospitalized at the Ospedale Policlinico San Martino, Genoa, Italy, with a diagnosis of fever and an uncommon clinical presentation characterised by a persistent leukopenia. Phylogenetic analysis revealed a closeness with influenza A(H1N1)pdm09 strains circulating in the US in May-June 2018. Prompt recognition of influenza infection led to a proper case management, demonstrating the crucial role of the continuous influenza surveillance programme

l-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain

Background and Aim: l-Acetyl-carnitine (LAC) exerts an energetic effect on nerves and muscles. Recently, preclinical experiments have demonstrated a central anti-nociceptive action. Objective: Our objective was to assess the effects of LAC on neuroprotection, pain, and function in carpal tunnel syndrome (CTS), a very frequent chronic compressive neuropathy. Methods: In a multicentre, examiner-blinded, clinical and neurophysiological 4-month study, we enrolled 82 patients and examined 120 hands with CTS of mild to moderate severity. Patients were assessed at baseline and 10, 60 and 120\uc2 days after treatment with LAC 500\uc2 mg twice daily (BID). All patients underwent a conduction study of the median nerve, the Boston Carpal Tunnel Questionnaire (BCTQ) and the Neuropathic Pain Symptom Inventory (NPSI). The primary endpoint was the sensory conduction velocity (SCV) of the median nerve. Results: The primary endpoint was met, with significant improvement of the SCV (P\uc2&nbsp

Studying functional networks in human brain through intracerebral spontaneous EEG

none6G.Arnulfo; A.Pigorini; M.Massimini; L.Nobili; A.Schenone; M.M. FatoArnulfo, Gabriele; Pigorini, A.; Massimini, M.; Nobili, L.; Schenone, Andrea; Fato, MARCO MASSIM

Proton therapy and src family kinase inhibitor combined treatments on U87 human glioblastoma multiforme cell line

Glioblastoma Multiforme (GBM) is the most common of malignant gliomas in adults with an exiguous life expectancy. Standard treatments are not curative and the resistance to both chemotherapy and conventional radiotherapy (RT) plans is the main cause of GBM care failures. Proton therapy (PT) shows a ballistic precision and a higher dose conformity than conventional RT. In this study we investigated the radiosensitive effects of a new targeted compound, SRC inhibitor, named Si306, in combination with PT on the U87 glioblastoma cell line. Clonogenic survival assay, dose modifying factor calculation and linear-quadratic model were performed to evaluate radiosensitizing effects mediated by combination of the Si306 with PT. Gene expression profiling by microarray was also conducted after PT treatments alone or combined, to identify gene signatures as biomarkers of response to treatments. Our results indicate that the Si306 compound exhibits a radiosensitizing action on the U87 cells causing a synergic cytotoxic effect with PT. In addition, microarray data confirm the SRC role as the main Si306 target and highlights new genes modulated by the combined action of Si306 and PT. We suggest, the Si306 as a new candidate to treat GBM in combination with PT, overcoming resistance to conventional treatments