1,840 research outputs found
252 F-SPONDIN MEDIATES CATABOLIC EFFECTS ON ARTICULAR CHONDROCYTES VIA ITS THROMBOSPONDIN REPEAT (TSR) DOMAIN
F-spondin (spondin-1) null mice exhibit increased bone formation, decreased osteoclast function and accelerated osteoarthritis
Open-label, randomized comparison of dolasetron versus ondansetron for prevention of nausea and vomiting during high-dose chemotherapy and stem cell transplantation
Multi-Terminal Superconducting Phase Qubit
Mesoscopic multi-terminal Josephson junctions are novel devices that provide
weak coupling between several bulk superconductors through a common normal
layer. Because of the nonlocal coupling of the superconducting banks, a current
flow between two of the terminals can induce a phase difference and/or current
flow in the other terminals. This "phase dragging" effect is used in designing
a new type of superconducting phase qubit, the basic element of a quantum
computer. Time-reversal symmetry breaking can be achieved by inserting a
pi-phase shifter into the flux loop. Logical operations are done by applying
currents. This removes the necessity for local external magnetic fields to
achieve bistability or controllable operations.Comment: 7 pages, 3 figure
Inhibition in multiclass classification
The role of inhibition is investigated in a multiclass support vector machine formalism inspired by the brain structure of insects. The so-called mushroom bodies have a set of output neurons, or classification functions,
that compete with each other to encode a particular input. Strongly active output neurons depress or inhibit the remaining outputs without knowing which is correct or incorrect. Accordingly, we propose to use a
classification function that embodies unselective inhibition and train it in the large margin classifier framework. Inhibition leads to more robust classifiers in the sense that they perform better on larger areas of appropriate hyperparameters when assessed with leave-one-out strategies. We also show that the classifier with inhibition is a tight bound to probabilistic exponential models and is Bayes consistent for 3-class problems.
These properties make this approach useful for data sets with a limited number of labeled examples. For larger data sets, there is no significant comparative advantage to other multiclass SVM approaches
Inhibition in multiclass classification
The role of inhibition is investigated in a multiclass support vector machine formalism inspired by the brain structure of insects. The so-called mushroom bodies have a set of output neurons, or classification functions,
that compete with each other to encode a particular input. Strongly active output neurons depress or inhibit the remaining outputs without knowing which is correct or incorrect. Accordingly, we propose to use a
classification function that embodies unselective inhibition and train it in the large margin classifier framework. Inhibition leads to more robust classifiers in the sense that they perform better on larger areas of appropriate hyperparameters when assessed with leave-one-out strategies. We also show that the classifier with inhibition is a tight bound to probabilistic exponential models and is Bayes consistent for 3-class problems.
These properties make this approach useful for data sets with a limited number of labeled examples. For larger data sets, there is no significant comparative advantage to other multiclass SVM approaches
Precursors of Cytochrome Oxidase in Cytochrome-Oxidase-Deficient Cells of Neurospora crassa
Three different cell types of Neurospora crassa deficient in cytochrome oxidase were studied: the nuclear mutant cni-1, the cytoplasmic mutant mi-1 and copper-depleted wild-type cells.
* 1.
The enzyme-deficient cells have retained a functioning mitochondrial protein synthesis. It accounted for 12–16% of the total protein synthesis of the cell. However, the analysis of mitochondrial translation products by gel electrophoresis revealed that different amounts of individual membrane proteins were synthesized. Especially mutant cni-1 produced large amounts of a small molecular weight translation product, which is barely detectable in wild-type.
* 2.
Mitochondrial preparations of cytochrome-oxidase-deficient cells were examined for precursors of cytochrome oxidase. The presence of polypeptide components of cytochrome oxidase in the mitochondria was established with specific antibodies. On the other hand, no significant amounts of heme a could be extracted.
* 3.
Radioactively labelled components of cytochrome oxidase were isolated by immunoprecipitation and analysed by gel electrophoresis. All three cell types contained the enzyme components 4–7, which are translated on cytoplasmic ribosomes. The mitochondrially synthesized components 1–3 were present in mi-1 mutant and in copper-depleted wild-type cells. In contrast, components 2 and 3 were not detectable in the nuclear mutant cni-1. Both relative and absolute amounts of these polypeptides in the enzyme-deficient cells were quite different from those in wild-type cells.
* 4.
The components of cytochrome oxidase found in the enzyme-deficient cells were tightly associated with the mitochondrial membranes.
* 5.
Processes, which affect and may control the production of enzyme precursors or their assembly to a functional cytochrome oxidase are discussed
Low-frequency characterization of quantum tunneling in flux qubits
We propose to investigate flux qubits by the impedance measurement technique
(IMT), currently used to determine the current--phase relation in Josephson
junctions. We analyze in detail the case of a high-quality tank circuit coupled
to a persistent-current qubit, to which IMT was successfully applied in the
classical regime. It is shown that low-frequency IMT can give considerable
information about the level anticrossing, in particular the value of the
tunneling amplitude. An interesting difference exists between applying the ac
bias directly to the tank and indirectly via the qubit. In the latter case, a
convenient way to find the degeneracy point in situ is described. Our design
only involves existing technology, and its noise tolerance is quantitatively
estimated to be realistic.Comment: 6 pages, 11 figures, to appear in Phys.Rev.
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