Intermediate targets and indicators for monetary policy: an introduction to the issues

Money supply ; Monetary policy - United States

United States Trade Flows for Selected Categories of Specialty Crops

Nationally, Florida ranked second in farm cash receipt from all crops and second, based on value, in vegetable production (USDA, 2003). It also ranked fourteenth out of all the states with respect to agricultural exports with its top exports, fruits and vegetables, falling within the category of specialty crops. According to the USDA (2003), Florida's agricultural exports helped to boost farm prices and income and supported approximately 17,000 jobs both on and off farm in 2001. As such, its agricultural exports are important to Florida's agricultural and statewide economy. From a Florida farm cash receipts perspective, increased imports could undermine revenue earnings from specialty crop production, especially if there is not a comparable growth in the exports of these crops. This report covered the period 1991 to 2002 and examined trade flows for selected specialty crops deemed important to Florida's agriculture. Overall, the US had a relatively high import level of the selected specialty crops. This was apparent from the widening trade gaps and the declining surpluses experienced by all commodities, with the exception of oranges and strawberries. CANMEX was the dominant supplier of vegetables, and growing imports from this group drove the growing vegetable trade deficit. With respect to fruits, CANMEX was also a dominant supplier and affected trade balances however, many of the declining fruit trade balances were due to declining exports to markets such as Asia and the Europe. CANMEX played a major role in the trade of foliage and floriculture but did not dominate the trade. Over the period 1991 to 2002 there were changes in the trade flows of the selected vegetables, fruits and foliage and floriculture. Two noticeable trends were the concentration of trade with CANMEX, especially with respect to vegetable exports and declining exports to Asia and Europe. Also noticeable were declining trade balances experienced by the majority of the commodities in this study. With free trade agreements, an increased inflow of goods is expected as trade barriers are lowered. Preparing for additional imports resulting from expanded regional free trade agreements in the western hemisphere requires the commitment of additional resources toward the expansion of existing markets and the development of potentially new markets.Crop Production/Industries, International Relations/Trade,

A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity.

Presynaptic homeostatic plasticity stabilizes information transfer at synaptic connections in organisms ranging from insect to human. By analogy with principles of engineering and control theory, the molecular implementation of PHP is thought to require postsynaptic signaling modules that encode homeostatic sensors, a set point, and a controller that regulates transsynaptic negative feedback. The molecular basis for these postsynaptic, homeostatic signaling elements remains unknown. Here, an electrophysiology-based screen of the Drosophila kinome and phosphatome defines a postsynaptic signaling platform that includes a required function for PI3K-cII, PI3K-cIII and the small GTPase Rab11 during the rapid and sustained expression of PHP. We present evidence that PI3K-cII localizes to Golgi-derived, clathrin-positive vesicles and is necessary to generate an endosomal pool of PI(3)P that recruits Rab11 to recycling endosomal membranes. A morphologically distinct subdivision of this platform concentrates postsynaptically where we propose it functions as a homeostatic controller for retrograde, trans-synaptic signaling

Cholinergic suppression: A postsynaptic mechanism of long-term associative learning

Food avoidance learning in the mollusc Pleurobranchaea entails reduction in the responsiveness of key brain interneurons in the feeding neural circuitry, the paracerebral feeding command interneurons (PCNs), to the neurotransmitter acetylcholine (AcCho). Food stimuli applied to the oral veil of an untrained animal depolarize the PCNs and induce the feeding motor program (FMP). Atropine (a muscarinic cholinergic antagonist) reversibly blocks the food-induced depolarization of the PCNs, implicating AcCho as the neurotransmitter mediating food detection. AcCho applied directly to PCN somata depolarizes them, indicating that the PCN soma membrane contains AcCho receptors and induces the FMP in the isolated central nervous system preparation. The AcCho response of the PCNs is mediated by muscariniclike receptors, since comparable depolarization is induced by muscarinic agonists (acetyl-ß -methylcholine, oxotremorine, pilocarpine), but not nicotine, and blocked by muscarinic antagonists (atropine, trifluoperazine). The nicotinic antagonist hexamethonium, however, blocked the AcCho response in four of six cases. When specimens are trained to suppress feeding behavior using a conventional food-avoidance learning paradigm (conditionally paired food and shock), AcCho applied to PCNs in the same concentration as in untrained animals causes little or no depolarization and does not initiate the FMP. Increasing the concentration of AcCho 10-100 times, however, induces weak PCN depolarization in trained specimens, indicating that learning diminishes but does not fully abolish AcCho responsiveness of the PCNs. This study proposes a cellular mechanism of long-term associative learning -- namely, postsynaptic modulation of neurotransmitter responsiveness in central neurons that could apply also to mammalian species

Enhancing whole-of-river conservation

We argue for improved conservation of freshwater ecosystems at catchment or eco-regional scales by explicit assignment of values to all river sections and wetlands, recognising current disturbance, and aiming for ‘no further harm’ to the commons. The need is indicated by the global deterioration of biodiversity and ecosystem services of rivers and wetlands, increasing demands on water and land resources, and climate change. Regional pressures include multiple jurisdictions, competing demands, piecemeal management, pollution and habitat impacts. Effective resource and conservation management needs to integrate multiple uses via governance of activities of stakeholders, recognising hydrogeomorphic, water quality and ecological properties of ecosystems. Complete ecological protection is impractical amidst water-resource and land-use development, but we suggest that all river reaches and wetlands be given a conservation rating based on habitat, biodiversity and connectivity values. We present a straightforward approach to spatial conservation rating of freshwaters, using hydrogeomorphic typology and assignment of conservation values on the basis of available information and expert elicitation. We illustrate the approach by using the large Burdekin River catchment in north-eastern Australia. This approach is complementary to more spatially focused conservation prioritisation and could greatly improve management for sustainability, reduce further decline in conservation values, and facilitate rehabilitation

Inflation: measurement and policy issues

The author surveys some problems in measuring inflation and examines the likely costs of anticipated and unanticipated inflation as well as the short-run costs of reducing inflation. He looks at the possibility that an inflationary bias may be implicit in the political economy aspects of the inflation problem, assesses the potential costs and benefits of zero inflation as a policy objective, and considers the possible implications of the inflation problem for monetary policy rules and for the independence of central banks.Inflation (Finance) ; Monetary policy ; Consumer price indexes ; Economic indicators

Genetic and Neuroanatomical Support for Functional Brain Network Dynamics in Epilepsy

Focal epilepsy is a devastating neurological disorder that affects an overwhelming number of patients worldwide, many of whom prove resistant to medication. The efficacy of current innovative technologies for the treatment of these patients has been stalled by the lack of accurate and effective methods to fuse multimodal neuroimaging data to map anatomical targets driving seizure dynamics. Here we propose a parsimonious model that explains how large-scale anatomical networks and shared genetic constraints shape inter-regional communication in focal epilepsy. In extensive ECoG recordings acquired from a group of patients with medically refractory focal-onset epilepsy, we find that ictal and preictal functional brain network dynamics can be accurately predicted from features of brain anatomy and geometry, patterns of white matter connectivity, and constraints complicit in patterns of gene coexpression, all of which are conserved across healthy adult populations. Moreover, we uncover evidence that markers of non-conserved architecture, potentially driven by idiosyncratic pathology of single subjects, are most prevalent in high frequency ictal dynamics and low frequency preictal dynamics. Finally, we find that ictal dynamics are better predicted by white matter features and more poorly predicted by geometry and genetic constraints than preictal dynamics, suggesting that the functional brain network dynamics manifest in seizures rely on - and may directly propagate along - underlying white matter structure that is largely conserved across humans. Broadly, our work offers insights into the generic architectural principles of the human brain that impact seizure dynamics, and could be extended to further our understanding, models, and predictions of subject-level pathology and response to intervention