Soil-transmitted helminth infections

More than a quarter of the world's population is at risk of infection with the soil-transmitted helminths Ascaris lumbricoides, hookworm (Ancylostoma duodenale and Necator americanus), Trichuris trichiura, and Strongyloides stercoralis. Infected children and adults present with a range of medical and surgical conditions, and clinicians should consider the possibility of infection in individuals living in, or returning from, endemic regions. Although safe and effective drugs are donated free to endemic countries, only half of at-risk children received treatment in 2016. This Seminar describes the epidemiology, lifecycles, pathophysiology, clinical diagnosis, management, and public health control of soil-transmitted helminths. Previous work has questioned the effect of population-level deworming; however, it remains beyond doubt that treatment reduces the severe consequences of soil-transmitted helminthiasis. We highlight the need for refined diagnostic tools and effective control options to scale up public health interventions and improve clinical detection and management of these infections

Response of Aphidius colemani to aphid sex pheromone varies depending on plant synergy and prior experience

A critical stage in the success of a parasitoid is the ability to locate a host within its habitat. It is hypothesized that a series of olfactory cues may be involved in altering the parasitoid's movement patterns at this stage of foraging. This paper focuses specifically on host habitat location and host location and the olfactory stimuli necessary to mediate the transition between these stages. Firstly, we confirm the ability of the parasitoid Aphidius colemani to detect the aphid sex pheromone at an electrophysiological level. Following this we investigate the effect of the sex pheromone component (4aS,7S,7aR)-nepetalactone on the movement patterns of A. colemani and its retention within an area. The key findings of this work are that A. colemani is able to detect the sex pheromone components, that parasitoid retention is increased by a synergy of nepetalactone and other host-associated cues and that foraging patterns are augmented by the presence of nepetalactone or experience associated with nepetalactone

The Role of Diet in the Management of Psoriasis: A Scoping Review

© 2023 The Author(s). Published by Cambridge University Press on behalf of The Nutrition Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Psoriasis is a chronic, systemic, immune-mediated, inflammatory skin disease associated with significant comorbidities. Globally, there are an estimated 60 million people living with psoriasis (PLwP). There is a growing body of evidence on the role of diet in psoriasis management and demand for dietary advice is high. However, there are no specific, evidence-based dietary guidelines. This scoping review summarises the literature on use and effectiveness of diet in the management of psoriasis to improve understanding of the evidence and assist PLwP and healthcare professionals (HCPs) to discuss diet. The findings were categorised into three themes (1) dietary intakes of PLwP, (2) the perceived role of diet in psoriasis management and (3) dietary approaches to manage psoriasis symptoms. In cross-sectional studies PLwP were reported to have higher fat and lower fibre intakes compared to controls, and lower psoriasis severity was associated with higher fibre intake. However, research is limited. PLwP perceive diet to have an impact on symptoms and make dietary modifications which are often restrictive. Systematic reviews and RCTs found certain dietary approaches improved symptoms, but only in specific populations (e.g., PLwP with obesity and PLwP with coeliac disease), and evidence for supplement use is inconclusive. The grey literature provides limited guidance to PLwP; focusing on weight-loss and associated comorbidities. Larger, controlled trials are required to determine dietary approaches for psoriasis management, especially in PLwP without obesity and non-coeliac PLwP. Further understanding of diet modification, information acquisition and experiences among PLwP will enhance holistic care for psoriasis management.Peer reviewe

Ipteks Sistem Informasi Manajemen Keuangan Daerah pada Uptd Balai Pelatihan Kesehatan Provinsi Sulawesi Utara

Implementation of SIMDA at UPTD Health Training Center of North Sulawesi Province used method applied finance SIMDA2.7.0.12 accrual based at UPTD Health Training Center of North Sulawesi Province was based on the Ordinance Ministry of Home Affairs No. 13 2006 about financial management is started of stages of planning, administration, accounting and reporting. Application techniqueSIMDA2.7.0.12version accrual based : according to the Ordinance Ministry of Home Affairs No. 13 2006 IPTEKS technique who applied on manufacture of SIMDA are covers by Budgeting Planning : RKA, RAPBD and other of DPA. Administration :Letter of Provision of Funds (SPD), Letter of Request Payment (SPP). From implementation of examination result finance at UPTD Health Training Center of North Sulawesi Province is showed : implementation of SIMDA 2.7.0.12accrual based has already done through the products produced, namely budgeting and administration have no constraints, while the obstacles faced in accounting and reporting products in producing Operational Reports (LO) and Budgeting and Administration is carried out according to the Ordinance Ministry of Home Affairs No. 13 2006about financial regional management, while the accounting reporting process is carried out according to the Ordinance Ministry of Home Affairs No. 642013 about the application of accrual based government accounting standards

Movement of transgenic plant-expressed Bt Cry1Ac proteins through high trophic levels

The movement of Bacillus thuringiensis (Berliner) (Bt) Cry1Ac endotoxin through high trophic levels was assessed to help elucidate the effects of Bt toxin on non-target insects. The diamondback moth (Plutella xylostella L., Lepidoptera: Plutellidae), the parasitic wasp (Cotesia vestalis Haliday, Hymenoptera: Braconidae) and the predatory green lacewing Chrysoperla carnea (Stephen) (Neuroptera: Chrysopidae) were used as a model system in this laboratory study. Bt-resistant P. xylostella larvae fed Cry1Ac-expressing transgenic oilseed rape (OSR, Brassica napus L., Cruciferae), before and after parasitization by C. vestalis, consumed Cry1Ac with the ingested plant material but only a proportion of Cry1Ac consumed was recovered from the bodies and faeces of P. xylostella larvae. Cry1Ac was not detected in newly emerged parasitoid larvae. In contrast, Cry1Ac was detected in C. carnea larvae fed on resistant P. xylostella larvae reared on Bt OSR. However, no Cry1Ac could be detected in C. carnea larvae when the lacewings were transferred to P. xylostella larvae reared on conventional OSR and tested 24-48 h. The metabolizing ability of Cry1Ac is discussed for the larvae of P. xylostella and C. carnea

IMPLEMENTASI BLENDED LEARNING DALAM MENINGKATKAN LITERASI MATEMATIKA DAN KESIAPAN BELAJAR PESERTA DIDIK

Penelitian ini bertujuan untuk 1). Menganalisis gaya belajar peserta didik yang memperoleh pembelajaran blended learning dengan model konvensional. 2). Menganalisis efektivitas pembelajaran Matematika dengan metode blended learning untuk meningkatkan literasi matematika peserta ditinjau dari gaya belajar (visual, auditorial dan kinestetik). 3). Menganalisis kesiapan belajar peserta didik dalam pembelajaran Matematika yang memperoleh pembelajaran model blended learning dan model konvensional ditinjau dari gaya belajar (visual, auditorial dan kinestetik). 4). Menganalisis korelasi antara literasi belajar matematika dengan kesiapan belajar peserta didik yang memperoleh pembelajaran blended learning dan pembelajaran konvensional. Penelitian ini merupakan penelitian yang menggunakan metode penelitian mixe method (campuran) tipe embedded design dan desainnya menggunakan quasi exsperiment. Penelitian ini dilaksanakan di SMA Negeri 1 Ciwaringin dengan subjek penelitian kelas X G dan X H. Instrumen yang digunakan dalam penelitian ini adalah tes tipe uraian kemampuan literasi matematika, angket kesiapan belajar dan angket gaya belajar dengan menggunakan model skala likert. Berdasarkan analisis data hasil penelitian, diperoleh kesimpulan: 1). Pembelajaran yang menggunakan model blended learning lebih baik dari pada peserta didik yang memperoleh pembelajaran konvensional ditinjau dari gaya belajar; 2). Pembelajaran matematika yang menggunakan dengan model blended learning memiliki pengaruh yang tinggi dalam meningkatkan literasi matematika peserta didik pada materi Perbandingan Trigonometri; 3). Pembelajaran matematika yang menggunakan dengan model blended learning memiliki pengaruh yang tinggi dalam meningkatkan kesiapan belajar peserta didik pada materi Perbandingan Trigonometri; 4) Terdapat korelasi antara literasi matematika dengan kesiapan peserta didik yang menggunakan pembelajaran model blended learning. Kata Kunci: Blended learning, Literasi Matematika, Kesiapan Belajar, Gaya Belaja

Ferroelectricity and resistive switching in BaTiO3_3 thin films with liquid electrolyte top contact for bioelectronic devices

We investigate ferroelectric- and resistive switching behavior in 18-nm-thick epitaxial BaTiO$_3$ (BTO) films in a model electrolyte-ferroelectric-semiconductor (EFS) configuration. The system is explored for its potential as a ferroelectric microelectrode in bioelectronics. The BTO films are grown by pulsed laser deposition (PLD) on semiconducting Nb-doped (0.5 wt\%) SrTiO$_{3}$ (Nb:STO) single crystal substrates. The ferroelectric properties of the bare BTO films are demonstrated by piezoresponse force microscopy (PFM) measurements. Cyclic voltammetry (CV) measurements in EFS configuration, with phosphate buffered saline (PBS) acting as the liquid electrolyte top contact, indicate characteristic ferroelectric switching peaks in the bipolar current-voltage loop. The ferroelectric nature of the observed switching peaks is confirmed by analyzing the current response of the EFS devices to unipolar voltage signals. Moreover, electrochemical impedance spectroscopy (EIS) measurements indicate bipolar resisitive switching behavior of the EFS devices, which is controlled by the remanent polarization state of the BTO layer. Our results represent a constitutive step towards the realization of neuroprosthetic implants and hybrid neurocomputational systems based on ferroelectric microelectrodes

Quantifying defence cascade responses as indicators of pig affect and welfare using computer vision methods

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