Do Patients with Bronchiectasis Have an Increased Risk of Developing Lung Cancer? A Systematic Review

Background: Initial evidence supports the hypothesis that patients with non-cystic fibrosis bronchiectasis (NCFB) have a higher risk of lung cancer. We systematically reviewed the available literature to define the characteristics of lung malignancies in patients with bronchiectasis and the characteristics of patients who develop bronchiectasis-associated lung cancer. Method: This study was performed based on the PRISMA guidelines. The review protocol was registered in PROSPERO. Results: The frequency rates of lung cancer in patients with NCFB ranged from 0.93% to 8.0%. The incidence rate was 3.96. Cancer more frequently occurred in the elderly and males. Three studies found an overall higher risk of developing lung cancer in the NCFB population compared to the non-bronchiectasis one, and adenocarcinoma was the most frequently reported histological type. The effect of the co-existence of NCFB and COPD was unclear. Conclusions: NCFB is associated with a higher risk of developing lung cancer than individuals without NCFB. This risk is higher for males, the elderly, and smokers, whereas concomitant COPD’s effect is unclear

Endoscopic Technologies for Peripheral Pulmonary Lesions: From Diagnosis to Therapy

Peripheral pulmonary lesions (PPLs) are frequent incidental findings in subjects when performing chest radiographs or chest computed tomography (CT) scans. When a PPL is identified, it is necessary to proceed with a risk stratification based on the patient profile and the characteristics found on chest CT. In order to proceed with a diagnostic procedure, the first-line examination is often a bronchoscopy with tissue sampling. Many guidance technologies have recently been developed to facilitate PPLs sampling. Through bronchoscopy, it is currently possible to ascertain the PPL’s benign or malignant nature, delaying the therapy’s second phase with radical, supportive, or palliative intent. In this review, we describe all the new tools available: from the innovation of bronchoscopic instrumentation (e.g., ultrathin bronchoscopy and robotic bronchoscopy) to the advances in navigation technology (e.g., radial-probe endobronchial ultrasound, virtual navigation, electromagnetic navigation, shape-sensing navigation, cone-beam computed tomography). In addition, we summarize all the PPLs ablation techniques currently under experimentation. Interventional pulmonology may be a discipline aiming at adopting increasingly innovative and disruptive technologies

Binary evolution with LOFT

This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of very faint X-ray binaries, orbital period distribution of black hole X-ray binaries and neutron star spin up. For a summary, we refer to the paper.Comment: White Paper in Support of the Mission Concept of the Large Observatory for X-ray Timing. (v2 few typos corrected

Codes and standards on computational wind engineering for structural design: State of art and recent trends

This paper first provides a wide overview about the design codes and standards covering the use of Computational Wind Engineering / Computational Fluid Dynamics (CWE/CFD) for wind-sensitive structures and built environment. Second, the paper sets out the basic assumptions and underlying concepts of the new Annex T "Simulations by Computational Fluid Dynamics (CFD/CWE)" of the revised version "Guide for the assessment of wind actions and effects on structures" issued by the Advisory Committee on Technical Recommendations for Constructions of the Italian National Research Council in February 2019 and drafted by the members of the Special Interest Group on Computational Wind Engineering of the Italian Association for Wind Engineering (ANIV-CWE). The same group is currently advising UNI CT021/SC1 in supporting the drafting of the new Annex K - "Derivation of design parameters from wind tunnel tests and numerical simulations" of the revised Eurocode 1: Actions on structures - Part 1-4: General actions - Wind actions. Finally, the paper outlines the subjects most open to development at the technical and applicative level

Multi-wavelength observations of 1RXH J173523.7-354013: revealing an unusual bursting neutron star

On 2008 May 14, the Burst Alert Telescope aboard the Swift mission triggered on a type-I X-ray burst from the previously unclassified ROSAT object 1RXH J173523.7-354013, establishing the source as a neutron star X-ray binary. We report on X-ray, optical and near-infrared observations of this system. The X-ray burst had a duration of ~2 h and belongs to the class of rare, intermediately long type-I X-ray bursts. From the bolometric peak flux of ~3.5E-8 erg/cm^2/s, we infer a source distance of D<9.5 kpc. Photometry of the field reveals an optical counterpart that declined from R=15.9 during the X-ray burst to R=18.9 thereafter. Analysis of post-burst Swift/XRT observations, as well as archival XMM-Newton and ROSAT data suggests that the system is persistent at a 0.5-10 keV luminosity of ~2E35 (D/9.5 kpc)^2 erg/s. Optical and infrared photometry together with the detection of a narrow Halpha emission line (FWHM=292+/-9 km/s, EW=-9.0+/-0.4 Angstrom) in the optical spectrum confirms that 1RXH J173523.7-354013 is a neutron star low-mass X-ray binary. The Halpha emission demonstrates that the donor star is hydrogen-rich, which effectively rules out that this system is an ultra-compact X-ray binary.Comment: Accepted for publication in MNRAS, 13 pages, 6 figures, 5 table

Gravitational waves from rapidly rotating neutron stars

Rapidly rotating neutron stars in Low Mass X-ray Binaries have been proposed as an interesting source of gravitational waves. In this chapter we present estimates of the gravitational wave emission for various scenarios, given the (electromagnetically) observed characteristics of these systems. First of all we focus on the r-mode instability and show that a 'minimal' neutron star model (which does not incorporate exotica in the core, dynamically important magnetic fields or superfluid degrees of freedom), is not consistent with observations. We then present estimates of both thermally induced and magnetically sustained mountains in the crust. In general magnetic mountains are likely to be detectable only if the buried magnetic field of the star is of the order of $B\approx 10^{12}$ G. In the thermal mountain case we find that gravitational wave emission from persistent systems may be detected by ground based interferometers. Finally we re-asses the idea that gravitational wave emission may be balancing the accretion torque in these systems, and show that in most cases the disc/magnetosphere interaction can account for the observed spin periods.Comment: To appear in 'Gravitational Waves Astrophysics: 3rd Session of the Sant Cugat Forum on Astrophysics, 2014', Editor: Carlos F. Sopuert

A multi-transition HCN and HCO+ study of 12 nearby active galaxies: AGN versus SB environments

Recent studies have indicated that the HCN-to-CO(J=1-0) and HCO+-to-HCN(J=1-0) ratios are significantly different between galaxies with AGN (active galactic nucleus) and SB (starburst) signatures. In order to study the molecular gas properties in active galaxies and search for differences between AGN and SB environments, we observed the HCN(J=1-0), (J=2-1), (J=3-2), HCO+(J=1-0) and HCO+(J=3-2), emission with the IRAM 30m in the centre of 12 nearby active galaxies which either exhibit nuclear SB and/or AGN signatures. Consistent with previous results, we find a significant difference of the HCN(J=2-1)-to-HCN(J=1-0), HCN(J=3-2)-to-HCN(J=1-0), HCO+(J=3-2)-to-HCO+(J=3-2), and HCO+-to-HCN intensity ratios between the sources dominated by an AGN and those with an additional or pure central SB: the HCN, HCO+ and HCO+-to-HCN intensity ratios tend to be higher in the galaxies of our sample with a central SB as opposed to the pure AGN cases which show rather low intensity ratios. Based on an LVG analysis of these data, i.e., assuming purely collisional excitation, the (average) molecular gas densities in the SB dominated sources of our sample seem to be systematically higher than in the AGN sources. The LVG analysis seems to further support systematically higher HCN and/or lower HCO+ abundances as well as similar or higher gas temperatures in AGN compared to the SB sources of our sample. Also, we find that the HCN-to-CO ratios decrease with increasing rotational number J for the AGN while they stay mostly constant for the SB sources.Comment: accepted for publication in ApJ; 20 pages, 7 figures; in emulateApJ forma

Accreting Millisecond X-Ray Pulsars

Accreting Millisecond X-Ray Pulsars (AMXPs) are astrophysical laboratories without parallel in the study of extreme physics. In this chapter we review the past fifteen years of discoveries in the field. We summarize the observations of the fifteen known AMXPs, with a particular emphasis on the multi-wavelength observations that have been carried out since the discovery of the first AMXP in 1998. We review accretion torque theory, the pulse formation process, and how AMXP observations have changed our view on the interaction of plasma and magnetic fields in strong gravity. We also explain how the AMXPs have deepened our understanding of the thermonuclear burst process, in particular the phenomenon of burst oscillations. We conclude with a discussion of the open problems that remain to be addressed in the future.Comment: Review to appear in "Timing neutron stars: pulsations, oscillations and explosions", T. Belloni, M. Mendez, C.M. Zhang Eds., ASSL, Springer; [revision with literature updated, several typos removed, 1 new AMXP added