Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients

Conceptual Model for the Replacement of the Horn of a Nineteenth Century Phonograph

[EN] 3D printing of missing parts of a cultural heritage artifact opens many possibilities and extends the challenges in the processes of intervention on cultural heritage assets. However, restoring these objects may not only mean the replacement of a missing element from its esthetic point of view, but restoring the function for which objects were created. In these processes, the replica of the object must be exact and of quality, but also specific. In this sense, the presented work is a multi-disciplinary attempt to reproduce the missing horn of a phonograph dated to the late nineteenth century. This phonograph belongs to the collection of the `Vicente Miralles Segarra¿ Telecommunication Museum of the Universitat Politècnica de València. The objective was to recover its esthetic, didactic, and functional levels, i.e restoring its ability to emit sound. To this end, several models were printed with different materials, and the quality of the recorded sound with the different horns was evaluated, assessing their similarity to that obtained from an original horn.Marín-Piñero, B.; Madrid García, JA.; Bachiller Martin, MC. (2018). Conceptual Model for the Replacement of the Horn of a Nineteenth Century Phonograph. Studies in Conservation. 64(4):240-248. https://doi.org/10.1080/00393630.2018.1492273S24024864