Individual metering and submetering for cooling application

In 2012 the Energy Efficiency Directive (EED) has set mandatory installation of individual metering and submetering systems for accounting thermal energy consumption in buildings where centralized heating/cooling sources are present, when technically feasible and cost efficient. As a consequence, direct thermal energy meters or indirect heat accounting systems have spread widely in residential buildings, for metering and sub-metering in space heating applications. On the other hand, individual metering of thermal energy in space cooling is a difficult task, due to the very different types of cooling systems and to the lack of technical and legal metrology regulation. In this paper possible solutions available for direct metering and submetering of different types of centralized cooling systems are discussed. Indeed, for direct metering application, the cooling fluid flow metering is a particularly crucial issue due to small pipe diameters and different fluid properties. Thus, the authors carried out an experimental comparison between a Coriolis flow-meter and an ultrasonic clamp-on flow-meter in the cooling fluid circuit of a direct expansion system. Tests have been performed at different operative temperature differences between flow and return, showing relative errors within ± 10%

Pequeños vertebrados del relleno kárstico del Pleistoceno Superior de Avetrana (Apulia, Sur de Italia)

The fossiliferous deposit (karst cavity) in La Grave, a locality near the small town of Avetrana (Taranto, south­ern Italy), has yielded numerous fossils of vertebrates. The remains of large mammals have been the subject of several studies. This paper examines the remains of small vertebrates and identifies four taxa of amphibians (Bufo bufo, Bufotes gr. B. viridis, Hyla gr. H. Arborea and Rana (s.l.) sp.), four taxa of reptiles (Testudo hermanni, Podarcis sp., Zamenis gr. Z. longissimus, Natrix natrix), and nine taxa of small mammals (Erinaceus europaeus, Crocidura suaveolens, Arvicola italicus, Microtus (Terricola) savii, Microtus (Microtus) arvalis, Apodemus gr. A. sylvaticus - A. flavicollis, Hystrix (Acanthion) vinogradovi, Oryctolagus cuniculus and Lepus corsicanus). From a biochronological point of view, the data on small and large vertebrates indicate an age between the beginning of the Late Pleistocene (MIS 5e) and the central part of MIS 3. The most recent fossiliferous layer (bed 8) is likely to have been deposited during a cooler period when compared to the previous layers.The data from small fossil vertebrates combined with those emerging from the large mammals and birds evidence the presence, near the karstic cavity, of open spaces (prairies) with pools of water, bordered by wooded areas and, not far, the presence of a rocky coastline.El depósito (cavidad kárstica) de La Grave, localidad cercana a la pequeña ciudad de Avetrana (Tarento, Italia meridional), ha dado lugar a numerosos fósiles de vertebrados. Los restos de grandes mamíferos han sido objeto de varios estudios. En este trabajo se examinan los restos de pequeños vertebrados y se identifican cuatro taxones de anfibios (Bufo bufo, Bufotes gr. B. viridis, Hyla gr. H. Arborea and Rana (s.l.) sp.), cuatro de reptiles (Testudo hermanni, Podarcis sp., Zamenis gr. Z. longissimus, Natrix natrix), y nueve de pequeños mamíferos (Erinaceus europaeus, Crocidura suaveolens, Arvicola italicus, Microtus (Terricola) savii, Microtus (Microtus) arva­lis, Apodemus gr. A. sylvaticus - A. flavicollis, Hystrix (Acanthion) vinogradovi, Oryctolagus cuniculus and Lepus corsicanus). Desde un punto de vista biocronológico, los datos sobre los vertebrados pequeños y grandes indican una edad entre el comienzo del Pleistoceno tardío (MIS 5e) y la parte central del MIS 3. Es probable que el estrato fosilífero más reciente (nivel 8) se haya depositado durante un período más frío en comparación con las capas anteriores. Los datos de pequeños vertebrados fósiles combinados con los que proceden de los grandes mamífe­ros y aves evidencian la presencia, cerca de la cavidad kárstica, de espacios abiertos (praderas) con charcos de agua, bordeados por zonas boscosas y, no muy lejos, la presencia de una costa rocosa

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

Background: Myeloid cells, such as macrophages and microglia, play a crucial role in neuroinflammation and have been recently identified as a novel therapeutic target, especially for chronic forms. The general aim would be to change the phenotype of myeloid cells from pro- to anti-inflammatory, favoring their tissue-trophic and regenerative functions. Myeloid cells, however, display a number of functional phenotypes, not immediately identifiable as pro- or anti-inflammatory, and associated to ambiguous markers. Methods: We employed in vitro assays to study macrophage polarization/differentiation in the presence of classical polarizing stimuli such as IFNγ (pro-inflammatory) and IL4 (anti-inflammatory). We induced neuroinflammation in mice by immunization with a myelin antigen and treated diseased mice with intracisternal delivery of an IL4-expressing lentiviral vector. We analyzed clinical, pathological, and immunological outcomes with a focus on myeloid cells. Results: We found that IL6, usually considered a pro-inflammatory cytokine, was released in vitro by macrophages treated with the anti-inflammatory cytokine IL4. We show the existence of macrophages expressing IL6 along with classical anti-inflammatory markers such as CD206 and demonstrate that these cells are immunosuppressive in vitro. In neuroinflamed mice, we show that IL4 delivery in the central nervous system (CNS) is associated with clinical and pathological protection from disease, associated with increased IL6 expression in infiltrating macrophages. Conclusions: IL6 is known to mediate both pro- and anti-inflammatory effects, having two distinct ways to induce cell-signaling: either through the membrane bound receptor (anti-inflammatory) or through trans-signaling (pro-inflammatory). We show here that IL6-expressing macrophages are associated to protection from neuroinflammation, suggesting that IL6 anti-inflammatory properties prevail in the CNS, and calling for a general reconsideration of IL6 in macrophage polarization

Effects of intensive lifestyle changes on erectile dysfunction in men

Introduction. Limited data are available supporting the notion that treatment of lifestyle risk factors may improve erectile dysfunction (ED). Aim. In the present study, we analyzed the effect of a program ofchanging in lifestyle designed to improve erectile function in subjects with ED or at increasing risk for ED. Methods. Men were identified in our database of subjects participating in randomized controlled trials evaluating the effect of lifestyle changes. A total of 209 subjects were randomly assigned to one of the two treatment groups. The 104 men randomly assigned to the intervention program received detailed advice about how to reduce body weight, improve quality of diet, and increase physical activity. The 105 subjects in the control group were given general information about healthy food choices and general guidance on increasing their level of physical activity. Main Outcome Measures. Changes in erectile function score (International Index of Erectile Function-5 [IIEF-5]; items 5, 15, 4, 2, and 7 from the full-scale IIEF-15) and dependence of the restoration of erectile function on the changes in lifestyle that were achieved. Results. Erectile function score improved in the intervention group. At baseline, 35 subjects in the intervention group and 38 subjects in the control group had normal erectile function (34% and 36%, respectively). After 2 years, these figures were 58 subjects in the intervention group and 40 subjects in the control group, respectively (56% and 38%, P = 0.015). There was a strong correlation between the success score and restoration of erectile function. Conclusions. It is possible to achieve an improvement of erectile function in men at risk by means of nonpharmacological intervention aiming at weight loss and increasing physical activity. © 2009 International Society for Sexual Medicine

Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia

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Obesity in Prader–Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches

Prader–Willi syndrome (PWS) is a genetic disorder caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region. The three main genetic subtypes are represented by paternal 15q11-q13 deletion, maternal uniparental disomy 15, and imprinting defect. Clinical picture of PWS changes across life stages. The main clinical characteristics are represented by short stature, developmental delay, cognitive disability and behavioral diseases. Hypotonia and poor suck resulting in failure to thrive are typical of infancy. As the subjects with PWS age, clinical manifestations such as hyperphagia, temperature instability, high pain threshold, hypersomnia and multiple endocrine abnormalities including growth hormone and thyroid-stimulating hormone deficiencies, hypogonadism and central adrenal insufficiency due to hypothalamic dysfunction occur. Obesity and its complications are the most common causes of morbidity and mortality in PWS. Several mechanisms for the aetiology of obesity in PWS have been hypothesized, which include aberration in hypothalamic pathways of satiety control resulting in hyperphagia, disruption in hormones regulating appetite and satiety and reduced energy expenditure. However, despite the advancement in the research field of the genetic basis of obesity in PWS, there are contradictory data on the management. Although it is mandatory to adopt obesity strategy prevention from infancy, there is promising evidence regarding the management of obesity in adulthood with current obesity drugs along with lifestyle interventions, although the data are limited. Therefore, the current manuscript provides a review of the current evidence on obesity and PWS, covering physiopathological aspects, obesity-related complications and conservative management

Randomised trial comparing biweekly oxaliplatin plus oral capecitabine versus oxaliplatin plus i.v. bolus fluorouracil/leucovorin in metastatic colorectal cancer patients: results of the Southern Italy Cooperative Oncology study 0401

Oxaliplatin combined with either fluorouracil/leucovorin (OXAFAFU) or capecitabine (OXXEL) has a demonstrated activity in metastatic colorectal cancer patients. We aimed at comparing these two regimens in terms of response rate (RR), safety, progression-free survival (PFS), and quality of life (QoL) of patients