1,975 research outputs found
Catalytic Reactive Distillation for the Esterification Process: Experimental and Simulation
In the present study, methyl acetate has been synthesized using esterification of acetic acid with methanol in a continuous packed bed catalytic reactive distillation column in the presence of novel Indion 180 ion exchange resin solid catalyst. The experiments were conducted at various operating conditions like reboiler temperature, reflux ratio, and different feed flow rates of the acetic acid and methanol. The non-ideal pseudo-homogeneous kinetic model has been developed for esterification of acetic acid with methanol in the presence of Indion 180 catalyst. The developed kinetic model was used for the simulation of the reactive distillation column for the synthesis of methyl acetate using equilibrium stage model in Aspen Plus version 7.3. The simulation results were compared with experimental results, and found that there is a good agreement between them. The sensitivity analyses were also carried out for the different parameters of bottom flow rate, feed temperatures of acetic acid and methanol, and feed flow rate of acetic acid and methanol.
This work is licensed under a Creative Commons Attribution 4.0 International License
Subwavelength atom localization via amplitude and phase control of the absorption spectrum
We propose a scheme for subwavelength localization of an atom conditioned
upon the absorption of a weak probe field at a particular frequency.
Manipulating atom-field interaction on a certain transition by applying drive
fields on nearby coupled transitions leads to interesting effects in the
absorption spectrum of the weak probe field. We exploit this fact and employ a
four-level system with three driving fields and a weak probe field, where one
of the drive fields is a standing-wave field of a cavity. We show that the
position of an atom along this standing wave is determined when probe field
absorption is measured. We find that absorption of the weak probe field at a
certain frequency leads to subwavelength localization of the atom in either of
the two half-wavelength regions of the cavity field by appropriate choice of
the system parameters. We term this result as sub-half-wavelength localization
to contrast it with the usual atom localization result of four peaks spread
over one wavelength of the standing wave. We observe two localization peaks in
either of the two half-wavelength regions along the cavity axis.Comment: Accepted for publication to Physical Review
Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release
© 2015 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)This study was funded by the British Heart Foundation (RG/09/002/2642 to F.M.M.-B.) and the Medical Research Council of the UK (G0901084 to F.M.M.-B.). ImageStream X was funded by the Wellcome Trust (101604/Z/13/Z). This work forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute of Health Research
Long-term MST radar observations of vertical wave number spectra of gravity waves in the tropical troposphere over Gadanki (13.5° N, 79.2° E): comparison with model spectra
Risk factors and perinatal outcome associated with low birth weight in a prospective cohort: is there a shift towards sustainable developmental goal 3
Background: Low birth weight is a socio, economic, cultural and community based health issue which reflects responsibility and commitment of local and national administrative authorities. It continues to be a cause of short and long term adverse perinatal outcome with a bearing on adult non communicable health risks.Methods: This is a prospective observational and analytic study to know the prevalence, risk factors and perinatal outcome of LBW, from July 2017 to December 2018 in department of Obstetrics and Gynecology, MIMS Medical College, Andhra Pradesh, India. Maternal risk factors and outcomes associated with LBW were defined through risk ratios.Results: 721 infants including 116 LBW and 605 NBW born during study period were included in the study. Prevalence of LBW was 16%. Preterm birth accounted for 35%, FGR for 13.8% and SGA for 51.2% of them. Maternal factors like age 35years, social status II to IV, below higher secondary education, house maker, primi gravida, grand multi para, BMI 24.9kg/M2, Hb<11 gm% were having higher RR for LBW. LBW infants showed frequent association with oligo or polyhydramnious and hemorrhagic or turbid amniotic fluid. They had higher risks for non reassuring fetal heart rate changes, for induced delivery or an elective caesarean section. More often they needed NICU care for longer duration and showed a higher risk for malformations and neonatal mortality. Overall perinatal mortality was 5.54 per 1000 live birth.Conclusions: LBW is a risk factor for neonatal morbidity and mortality; which can be minimised by institutional delivery. High prevalence PTB (35%) warrants obstetricians to be more vigilant about indentifying the risk factors and adequate management planning. Constitutionally small baby at birth probably needs redefining normal birth weight for different ethnicity
Prediction of the Atomization Energy of Molecules Using Coulomb Matrix and Atomic Composition in a Bayesian Regularized Neural Networks
Exact calculation of electronic properties of molecules is a fundamental step
for intelligent and rational compounds and materials design. The intrinsically
graph-like and non-vectorial nature of molecular data generates a unique and
challenging machine learning problem. In this paper we embrace a learning from
scratch approach where the quantum mechanical electronic properties of
molecules are predicted directly from the raw molecular geometry, similar to
some recent works. But, unlike these previous endeavors, our study suggests a
benefit from combining molecular geometry embedded in the Coulomb matrix with
the atomic composition of molecules. Using the new combined features in a
Bayesian regularized neural networks, our results improve well-known results
from the literature on the QM7 dataset from a mean absolute error of 3.51
kcal/mol down to 3.0 kcal/mol.Comment: Under review ICANN 201
Review paper: Application of the Pulsed Eddy Current Technique to Inspect Pipelines of Nuclear Plants
Local wall thinning in pipelines affects the structural integrity of industries, such as nuclear power plants
(NPPs). In the present study, a development of pulsed eddy current (PEC) technology that detects the wall thinning of pipelines covered with insulation is reviewed. The methods and experimental results, which have two kinds of probe with a single and double core, were compared. For this purpose, the single and double core probes having one and two excitation coils have been devised, and the differential probe with two Hall sensors has been fabricated to measure the wall thinning in insulated pipelines. The test sample is a stainless steel having different thickness, laminated by plastic insulation to simulate the pipelines in NPPs. The excitation coils in the probe is driven by a rectangular current pulse, the difference of two Hall sensors has been measured as a resultant PEC signal. The peak value of the detected signal is used to describe the wall thinning. The double core probe has better performance to detect the wall thinning covered with insulation; the single core probe can detect the wall thinning up to an insulation thickness of 18 mm, whereas the double probe can detect up to 25 mm. The results show that the double core PEC probe has the potential to detect the wall thinning in an
insulated pipeline of the NPPs
Expression of renal aquaporins 1, 2, and 3 in a rat model of cisplatin-induced polyuria
Expression of renal aquaporins 1, 2, and 3 in a rat model of cisplatin-induced polyuria.BackgroundCisplatin (CP)-induced polyuria in rats is attributed to decreased medullary hypertonicity and/or an end-organ resistance to vasopressin. However, the roles of renal aquaporins (AQPs) have not yet been explored.MethodsMale Sprague-Dawley rats (230 to 245 g) received either a single injection of CP (5 mg/kg, N = 4) or saline (N = 4) intraperitoneally five days before sacrifice. Urine, blood, and kidney samples were analyzed.ResultsPlatinum accumulated in the cortex and outer medulla of CP-treated rats (39.05 ± 7.50 and 36.48 ± 12.44 μg/g vs. 2.52 ± 0.43 and 1.87 ± 0.84 μg/g dry tissue in controls, respectively). Histologically, tubular damage and decreased AQP1 immunolabeling were detected in the S3 segment of proximal tubules. CP treatment caused 4.4- and 4.8-fold increases, respectively, in blood urea nitrogen and urine volume, and a 4.4-fold decrease in urine osmolality. Immunoblots showed that AQP2 and AQP3 were significantly reduced to 33 ± 10% (P < 0.001) and 69 ± 11% (P < 0.05), respectively, in the inner medulla of CP-treated rats. Immunocytochemical analysis showed a decrease in AQP2 labeling in the inner medulla of CP-treated rats. Northern hybridization revealed a 33 ± 11% (P < 0.002) decrease in AQP2 mRNA expression in the inner medulla of CP-treated rats. AQP1 protein expression levels were modestly (67 ± 7%, P = 0.057) and significantly (53 ± 13%, P < 0.007) decreased in outer and inner medullae, respectively, of CP-treated rats.ConclusionsCP-induced polyuria in rats is associated with a significant decrease in the expression of collecting duct (AQP2 and AQP3) and proximal nephron and microvascular (AQP1) water channels in the inner medulla
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