20,467 research outputs found
Spread Supersymmetry
In the multiverse the scale of SUSY breaking, \tilde{m} = F_X/M_*, may scan
and environmental constraints on the dark matter density may exclude a large
range of \tilde{m} from the reheating temperature after inflation down to
values that yield a LSP mass of order a TeV. After selection effects, the
distribution for \tilde{m} may prefer larger values. A single environmental
constraint from dark matter can then lead to multi-component dark matter,
including both axions and the LSP, giving a TeV-scale LSP lighter than the
corresponding value for single-component LSP dark matter.
If SUSY breaking is mediated to the SM sector at order X^* X, only squarks,
sleptons and one Higgs doublet acquire masses of order \tilde{m}. The gravitino
mass is lighter by a factor of M_*/M_Pl and the gaugino masses are suppressed
by a further loop factor. This Spread SUSY spectrum has two versions; the
Higgsino masses are generated in one from supergravity giving a wino LSP and in
the other radiatively giving a Higgsino LSP. The environmental restriction on
dark matter fixes the LSP mass to the TeV domain, so that the squark and
slepton masses are order 10^3 TeV and 10^6 TeV in these two schemes. We study
the spectrum, dark matter and collider signals of these two versions of Spread
SUSY. The Higgs is SM-like and lighter than 145 GeV; monochromatic photons in
cosmic rays arise from dark matter annihilations in the halo; exotic short
charged tracks occur at the LHC, at least for the wino LSP; and there are the
eventual possibilities of direct detection of dark matter and detailed
exploration of the TeV-scale states at a future linear collider. Gauge coupling
unification is as in minimal SUSY theories.
If SUSY breaking is mediated at order X, a much less hierarchical spectrum
results---similar to that of the MSSM, but with the superpartner masses 1--2
orders of magnitude larger than in natural theories.Comment: 20 pages, 5 figure
The medical treatment of Cushing's disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery
BACKGROUND: The role of dopamine agonists in the treatment of Cushing's disease (CD) has been previously debated.
AIM: The aim of this study was to evaluate the effectiveness of short-term (3 months) and long-term (12-24 months) treatment with cabergoline in patients with CD. Patients and Methods: 20 patients with CD unsuccessfully treated by surgery entered the study. Cabergoline was administered at an initial dose of 1 mg/wk, with a monthly increase of 1 mg, until urinary cortisol levels normalized or the maximal dose of 7 mg/wk was achieved. The responsiveness to treatment was evaluated according to changes in urinary cortisol excretion. A decrease greater than 25% was considered as a partial response, whereas complete normalization was considered as a full response at short-term evaluation; persistence of normal cortisol excretion was the only criterion to evaluate the response at long-term evaluation.
RESULTS: After short-term treatment, 15 (75%) patients were responsive to cabergoline treatment. Among these, normalization of cortisol excretion was maintained in 10, whereas treatment escape was observed in five patients after 6-18 months. Among the 10 long-term responsive patients, eight were followed for 24 months, whereas the remaining two were followed for 12-18 months, due to cabergoline withdrawal for intolerance. A sustained control of cortisol secretion for 24 month cabergoline treatment at the maximal dose ranging from 1-7 mg/wk (median: 3.5) without significant side effects, was obtained in eight of 20 (40%) patients.
CONCLUSIONS: The results of this study demonstrated that cabergoline treatment is effective in controlling cortisol secretion for at least 1-2 yr in more than one third of a limited population of patients with CD. If this evidence is confirmed by additional studies, this agent may be considered as a useful treatment option in patients with CD who are unsuccessfully treated by neurosurgery
Determining R-parity violating parameters from neutrino and LHC data
In supersymmetric models neutrino data can be explained by R-parity violating
operators which violate lepton number by one unit. The so called bilinear model
can account for the observed neutrino data and predicts at the same time
several decay properties of the lightest supersymmetric particle. In this paper
we discuss the expected precision to determine these parameters by combining
neutrino and LHC data and discuss the most important observables. We show that
one can expect a rather accurate determination of the underlying R-parity
parameters assuming mSUGRA relations between the R-parity conserving ones and
discuss briefly also the general MSSM as well as the expected accuracies in
case of a prospective e+ e- linear collider. An important observation is that
several parameters can only be determined up to relative signs or more
generally relative phases.Comment: 13 pages, 13 figure
Fitting Neutrino Physics with a U(1)_R Lepton Number
We study neutrino physics in the context of a supersymmetric model where a
continuous R-symmetry is identified with the total Lepton Number and one
sneutrino can thus play the role of the down type Higgs. We show that
R-breaking effects communicated to the visible sector by Anomaly Mediation can
reproduce neutrino masses and mixing solely via radiative contributions,
without requiring any additional degree of freedom. In particular, a relatively
large reactor angle (as recently observed by the Daya Bay collaboration) can be
accommodated in ample regions of the parameter space. On the contrary, if the
R-breaking is communicated to the visible sector by gravitational effects at
the Planck scale, additional particles are necessary to accommodate neutrino
data.Comment: 19 pages, 3 figures; v2: references added, constraints updated,
overall conclusions unchange
Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents
Greater blood pressure (BP) is associated with greater left ventricular mass indexed to height2.7 (LVMi2.7) in adolescents. This study examined whether greater BP variability and reduced night-time dipping are associated with cardiac remodeling in a general population of adolescents. A cross-sectional analysis was undertaken in 587 UK adolescents (mean age 17.7 years; 43.1% male). BP was measured in a research clinic and using 24-hour ambulatory monitoring. We examined associations (for both systolic and diastolic BP) of: 1) clinic and 24-hour mean BP; 2) measures of 24-hour BP variability: standard deviation weighted for day/night (SDdn), variability independent of the mean (VIM) and average real variability (ARV); and 3) night-time dipping with cardiac structures. Cardiac structures were assessed by echocardiography: 1) LVMi2.7; 2) relative wall thickness (RWT); 3) left atrial diameter indexed to height (LADi) and 4) left ventricular internal diameter in diastole (LVIDD). Higher systolic BP was associated with greater LVMi2.7. Systolic and diastolic BP were associated with greater RWT. Associations were inconsistent for LADi and LVIDD. There was evidence for associations between both greater SDdn and ARV and higher RWT (per 1 SD higher diastolic ARV, mean difference in RWT was 0.13 SDs, 95% CI 0.045 to 0.21); these associations with RWT remained after adjustment for mean BP. There was no consistent evidence of associations between night-time dipping and cardiac structure. Measurement of BP variability, even in adolescents with blood pressure in the physiologic range, might benefit risk of cardiovascular remodeling assessment
Time-to-birth prediction models and the influence of expert opinions
Preterm birth is the leading cause of death among children under five years old. The pathophysiology and etiology of preterm labor are not yet fully understood. This causes a large number of unnecessary hospitalizations due to high--sensitivity clinical policies, which has a significant psychological and economic impact. In this study, we present a predictive model, based on a new dataset containing information of 1,243 admissions, that predicts whether a patient will give birth within a given time after admission. Such a model could provide support in the clinical decision-making process. Predictions for birth within 48 h or 7 days after admission yield an Area Under the Curve of the Receiver Operating Characteristic (AUC) of 0.72 for both tasks. Furthermore, we show that by incorporating predictions made by experts at admission, which introduces a potential bias, the prediction effectiveness increases to an AUC score of 0.83 and 0.81 for these respective tasks
Gluon fusion contribution to W+W- + jet production
We describe the computation of the process that contributes
to the production of two -bosons and a jet at the CERN Large Hadron Collider
(LHC). While formally of next-to-next-to-leading order (NNLO) in QCD, this
process can be evaluated separately from the bulk of NNLO QCD corrections
because it is finite and gauge-invariant. It is also enhanced by the large
gluon flux and by selection cuts employed in the Higgs boson searches in the
decay channel , as was first pointed out by Binoth {\it et al.}
in the context of production. For cuts employed by the ATLAS
collaboration, we find that the gluon fusion contribution to
enhances the background by about ten percent and can lead to moderate
distortions of kinematic distributions which are instrumental for the ongoing
Higgs boson searches at the LHC. We also release a public code to compute the
NLO QCD corrections to this process, in the form of an add-on to the package
{\tt MCFM}.Comment: 13 pages, 4 figures, 3 table
Time periodicity and dynamical stability in two-boson systems
We calculate the period of recurrence of dynamical systems comprising two
interacting bosons. A number of theoretical issues related to this problem are
discussed, in particular, the conditions for small periodicity. The knowledge
gathered in this way is then used to propose a notion of dynamical stability
based on the stability of the period. Dynamical simulations show good agreement
with the proposed scheme. We also apply the results to the phenomenon known as
coherent population trapping and find stability conditions in this specific
case.Comment: 7+ pages, 5 figure
A critical look at studies applying over-sampling on the TPEHGDB dataset
Preterm birth is the leading cause of death among young children and has a large prevalence globally. Machine learning models, based on features extracted from clinical sources such as electronic patient files, yield promising results. In this study, we review similar studies that constructed predictive models based on a publicly available dataset, called the Term-Preterm EHG Database (TPEHGDB), which contains electrohysterogram signals on top of clinical data. These studies often report near-perfect prediction results, by applying over-sampling as a means of data augmentation. We reconstruct these results to show that they can only be achieved when data augmentation is applied on the entire dataset prior to partitioning into training and testing set. This results in (i) samples that are highly correlated to data points from the test set are introduced and added to the training set, and (ii) artificial samples that are highly correlated to points from the training set being added to the test set. Many previously reported results therefore carry little meaning in terms of the actual effectiveness of the model in making predictions on unseen data in a real-world setting. After focusing on the danger of applying over-sampling strategies before data partitioning, we present a realistic baseline for the TPEHGDB dataset and show how the predictive performance and clinical use can be improved by incorporating features from electrohysterogram sensors and by applying over-sampling on the training set
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