519 research outputs found

    Using Insights from Psychology and Language to Improve How People Reason with Description Logics

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    Inspired by insights from theories of human reasoning and language, we propose additions to the Manchester OWL Syntax to improve comprehensibility. These additions cover: functional and inverse functional properties, negated conjunction, the definition of exceptions, and existential and universal restrictions. By means of an empirical study, we demonstrate the effectiveness of a number of these additions, in particular: the use of solely to clarify the uniqueness of the object in a functional property; the replacement of and with intersection in conjunction, which was particularly beneficial in negated conjunction; the use of except as a substitute for and not; and the replacement of some with including and only with noneOrOnly, which helped in certain situations to clarify the nature of these restrictions

    Access to Intrathecal Baclofen Treatment for Children with Cerebral Palsy in European Countries: An SCPE Survey Reveals Important Differences

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    Aim: The aim is to study access to intrathecal baclofen (ITB) for children with cerebral palsy (CP) in Europe, as an indicator of access to advanced care. Methods: Surveys were sent to CP registers, clinical networks, and pump manufacturers. Enquiries were made about ITB treatment in children born in 1990 to 2005 by sex, CP type, level of gross motor function classification system (GMFCS) and age at the start of treatment. Access to ITB was related to the country's gross domestic product (GDP) and % GDP spent on health. Results: In 2011 population-based data from Sweden, Norway, England, Portugal, Slovenia, and Denmark showed that 114 (3.4%) of 3,398 children with CP were treated with ITB, varying from 0.4 to 4.7% between centers. The majority of the children were at GMFCS levels IV-V and had bilateral spastic CP. In Sweden, dyskinetic CP was the most commonly treated subtype. Boys were more often treated with ITB than girls (p = 0.014). ITB was reported to be available for children with CP in 25 of 43 countries. Access to ITB was associated with a higher GDP and %GDP spent on health (p < 0.01). Updated information from 2019 showed remaining differences between countries in ITB treatment and sex difference in treated children was maintained. Conclusion: There is a significant difference in access to ITB for children with CP across Europe. More boys than girls are treated. Access to ITB for children with CP is associated with GDP and percent of GDP spent on health in the country.info:eu-repo/semantics/publishedVersio

    Angular sensitivity of blowfly photoreceptors: intracellular measurements and wave-optical predictions

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    The angular sensitivity of blowfly photoreceptors was measured in detail at wavelengths λ = 355, 494 and 588 nm. The measured curves often showed numerous sidebands, indicating the importance of diffraction by the facet lens. The shape of the angular sensitivity profile is dependent on wavelength. The main peak of the angular sensitivities at the shorter wavelengths was flattened. This phenomenon as well as the overall shape of the main peak can be quantitatively described by a wave-optical theory using realistic values for the optical parameters of the lens-photoreceptor system. At a constant response level of 6 mV (almost dark adapted), the visual acuity of the peripheral cells R1-6 is at longer wavelengths mainly diffraction limited, while at shorter wavelengths the visual acuity is limited by the waveguide properties of the rhabdomere. Closure of the pupil narrows the angular sensitivity profile at the shorter wavelengths. This effect can be fully described by assuming that the intracellular pupil progressively absorbs light from the higher order modes. In light-adapted cells R1-6 the visual acuity is mainly diffraction limited at all wavelengths.

    Development of the rhopalial nervous system in Aurelia sp.1 (Cnidaria, Scyphozoa)

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    We examined the development of the nervous system in the rhopalium, a medusa-specific sensory structure, in Aurelia sp.1 (Cnidaria, Scyphozoa) using confocal microscopy. The rhopalial nervous system appears primarily ectodermal and contains neurons immunoreactive to antibodies against tyrosinated tubulin, taurine, GLWamide, and FMRFamide. The rhopalial nervous system develops in an ordered manner: the presumptive gravity-sensing organ, consisting of the lithocyst and the touch plate, differentiates first; the “marginal center,” which controls swimming activity, second; and finally, the ocelli, the presumptive photoreceptors. At least seven bilaterally arranged neuronal clusters consisting of sensory and ganglion cells and their neuronal processes became evident in the rhopalium during metamorphosis to the medusa stage. Our analysis provides an anatomical framework for future gene expression and experimental studies of development and functions of scyphozoan rhopalia

    An ontological approach to creating an Andean Weaving Knowledge Base

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    Andean textiles are products of one of the richest, oldest and continuous weaving traditions in the world. Understanding the knowledge and practice of textile production as a form of cultural heritage is particularly relevant in the Andean context due to erosion of clothing traditions, reuse of traditional textiles on commodities targeted at the tourism market, and loss of knowledge embedded in textile production. ``Weaving Communities of Practice'' was a pilot project that aimed to create a knowledge base of Andean weaving designed to contribute to curatorial practice and heritage policy. The research team gathered data on the chain of activities, instruments, resources, peoples, places and knowledge involved in the production of textiles, relating to over 700 textile samples. A major part of the project has been the modelling and representation of the knowledge of domain experts and information about the textile objects themselves in the form of an OWL ontology, and the development of a suite of search facilities to be supported by the ontology. This paper describes the research challenges faced in developing the ontology and search facilities, the methodology adopted, the design and implementation of the system, and the design and outcomes of a user evaluation of the system undertaken with a group of domain experts

    A proposed disability complexity scale to describe the multi-facted needs of disabled children and young people.

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    There are validated measures of functioning for disabled children but no recognised scale of complexity. Many disabled children have multi-faceted needs. All need to be addressed to achieve best participation and quality of life. Aim: To develop a scale of complexity that is easy to apply in a range of clinic settings, relevant to individual clinical care and service planning. Method : Data were analysed from a retrospective review of 8392 structured electronic clinic letters from 1999 children accessing the paediatric disability clinics in Sunderland, north-east England, June 2007-May 2012. The numbers of health conditions (C), technology dependencies (T), family- reported issues (F) and need for round the clock care (R) were calculated and compared for those with different conditions. Results : The 699 children with intellectual disabilities (ID) compared to the 1299 without ID had significantly more: Needs overall (mean 5.81, range 1-23 with ID; mean 2.22, range 0-19 without ID) Health conditions (mean 5.41, range 0-18 with ID; mean 2.40, range 0-12 without ID) Technology dependencies (mean 0.16, range 0-4 with ID; mean 0.03, range 0-2 without ID) Family reported issues (mean 0.53, range 0-5 with ID; mean 0.19; range 0-5 without ID) and were Need for round the clock care (mean 0.18, range 0-1 with ID; mean 0.02, range 0-1 without ID)p-value <0.0001 in all cases. Children with ID plus cerebral palsies and epilepsies had more than double the number of needs overall than those without. The group who died had the highest burden of needs overall (mean 15, p-value <0.05). Conclusion: A disability complexity scale has been proposed and field-tested. It is a practical way to quantify complexity in a way that identifies the resources required to care for individuals as well as to commission and design services for populations of disabled children and young people

    Predator-Induced Vertical Behavior of a Ctenophore

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    Although many studies have focused on Mnemiopsis leidyi predation, little is known about the role of this ctenophore as prey when abundant in native and invaded pelagic systems. We examined the response of the ctenophore M. leidyi to the predatory ctenophore Beroe ovata in an experiment in which the two species could potentially sense each other while being physically separated. On average, M. leidyi responded to the predator’s presence by increasing variability in swimming speeds and by lowering their vertical distribution. Such behavior may help explain field records of vertical migration, as well as stratified and near-bottom distributions of M. leidyi

    Do children with neurological disabilities use more inpatient resources: an observational study.

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    BACKGROUND: Advances in healthcare have improved the survival of children with neurological disabilities (ND). Studies in the US have shown that children with ND use a substantial proportion of resources in children's hospitals, however, little research has been conducted in the UK. We aimed to test the hypothesis that children with neurological disabilities use more inpatient resources than children without neurological disabilities, and to quantify any significant differences in resource use. METHODS: A retrospective observational study was conducted, looking at the number of hospital admissions, total inpatient days and the reason for admissions for paediatric inpatients from January 1st to March 31st 2015. Inpatients were assigned into one of three groups: children without ND, children with one ND, and children with more than one ND. RESULTS: The sample population included 942 inpatients (mean age 6y 6mo). Children with at least one ND accounted for 15.3% of the inpatients, 17.7% of total hospital inpatient admission episodes, and 27.8% of the total inpatients days. Neurological disability had a statistically significant effect on total hospital admissions (p < 0.001). Neurological disability also had a statistically significant effect on total inpatient days (p < 0.001). Neurological disability increased the length of inpatient stay across medicine, specialties, and surgery. CONCLUSIONS: Children with ND had more frequent hospital admission episode and longer inpatient stays. We identified a smaller group within this population, with arguably more complex neurological disabilities, children with more than one ND. This group had the highest number of admissions and longest inpatient stays. More frequent hospital admissions and longer inpatient stays may place children with ND at greater risk of the adverse effects of hospitalisations. We recommend further investigations looking at each the effects of the different categories of ND on inpatient resource use, and repeat of this study at a national level and over a longer period of time
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