168 research outputs found
The magnetic phase diagram of underdoped YBa2Cu3Oy inferred from torque magnetization and thermal conductivity
Strong evidence for charge-density correlation in the underdoped phase of the
cuprate YBa2Cu3Oy was obtained by nuclear magnetic resonance (NMR) and resonant
x-ray scatter- ing. The fluctuations were found to be enhanced in strong
magnetic fields. Recently, 3D (three dimensional) charge-density wave (CDW)
formation with long-range order (LRO) was observed by x-ray diffraction in H
>15 T. To elucidate how the CDW transition impacts the pair condensate, we have
used torque magnetization to 45 T and thermal conductivity to
construct the magnetic phase diagram in untwinned crystals with hole density p
= 0.11. We show that the 3D CDW transitions appear as sharp features in the
susceptibility and at the fields HK and Hp, which define phase
boundaries in agreement with spectroscopic techniques. From measurements of the
melting field Hm(T) of the vortex solid, we obtain evidence for two vortex
solid states below 8 K. At 0.5 K, the pair condensate appears to adjust to the
3D CDW by a sharp transition at 24 T between two vortex solids with very
different shear moduli. At even higher H (42 T) the second vortex solid melts
to a vortex liquid which survives to fields well above 45 T. de Haas-van Alphen
oscillations appear at fields 24-28 T, below the lower bound for the upper
critical field Hc2.Comment: 7 pages, 8 figures; New version of previous posting, reporting torque
measurements to 45 Tesla and final magnetic phase diagra
Liver Transplantation for Advanced Liver Disease with Alpha-1antitrypsin Deficiency
ALPHA-1-antitrypsin deficiency associated with chronic obstructive airway disease was recognized in 1963 by Laurell and Ericksson.1 In 1969, Sharp2 described the first cases of alpha-1-antitrypsin-deficiency disease in children with cirrhosis. Since then, this inborn error has been recognized as one of the more common factors in cirrhosis of infancy and childhood,3 including “neonatal hepatitis.”4 Alpha-1-antitrypsin is a glycoprotein that accounts for a major portion of the alpha-1 globulin fraction of the serum.5 It is responsible for approximately 90 per cent of the antitrypsin activity6 of the serum, and it also inhibits several other plasma enzymes, including plasmin,7 elastase,8 collagenase,9 and. © 1980, Massachusetts Medical Society. All rights reserved
The planar thermal Hall conductivity in the Kitaev magnet {\alpha}-RuCl3
We report detailed measurements of the Onsager-like planar thermal Hall
conductivity in -RuCl, a spin-liquid candidate of
topical interest. With the thermal current and magnetic field
(zigzag axis), the observed varies strongly
with temperature (1-10 K). The results are well-described by bosonic edge
excitations which evolve to topological magnons at large . Fits to
yield a Chern number and a band energy 1
meV, in agreement with sharp modes seen in electron spin-resonance experiments.
The bosonic character is incompatible with half-quantization of
.Comment: 7 pages, 3 figure
Quantum Tricritical Points in NbFe
Quantum critical points (QCPs) emerge when a 2nd order phase transition is
suppressed to zero temperature. In metals the quantum fluctuations at such a
QCP can give rise to new phases including unconventional superconductivity.
Whereas antiferromagnetic QCPs have been studied in considerable detail
ferromagnetic (FM) QCPs are much harder to access. In almost all metals FM QCPs
are avoided through either a change to 1st order transitions or through an
intervening spin-density-wave (SDW) phase. Here, we study the prototype of the
second case, NbFe. We demonstrate that the phase diagram can be modelled
using a two-order-parameter theory in which the putative FM QCP is buried
within a SDW phase. We establish the presence of quantum tricritical points
(QTCPs) at which both the uniform and finite susceptibility diverge. The
universal nature of our model suggests that such QTCPs arise naturally from the
interplay between SDW and FM order and exist generally near a buried FM QCP of
this type. Our results promote NbFe as the first example of a QTCP, which
has been proposed as a key concept in a range of narrow-band metals, including
the prominent heavy-fermion compound YbRhSi.Comment: 21 pages including S
A novel OSA-related model of intermittent hypoxia in endothelial cells under flow reveals pronounced inflammatory pathway activation
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of upper airway obstruction and subsequent hypoxia. In patients with OSA, severity and number of these hypoxic events positively correlate with the extent of associated cardiovascular pathology. The molecular mechanisms underlying intermittent hypoxia (IH)-driven cardiovascular disease in OSA, however, remain poorly understood—partly due to the lack of adequate experimental models. Here, we present a novel experimental approach that utilizes primary human endothelial cells cultivated under shear stress. Oxygen partial pressure dynamics were adopted in our in vitro model according to the desaturation-reoxygenation patterns identified in polysomnographic data of severe OSA patients (n = 10, with 892 severe desaturations, SpO2<80%). Using western blot analysis, we detected a robust activation of the two major inflammatory pathways ERK and NF-κB in endothelial cells, whereas no HIF1α and HIF2α protein stabilization was observed. In line with these findings, mRNA and protein expression of the pro-inflammatory adhesion and signaling molecule ICAM-1 and the chemokine CCL2 were significantly increased. Hence, we established a novel in vitro model for deciphering OSA-elicited effects on the vascular endothelium. First data obtained in this model point to the endothelial activation of pro-inflammatory rather than hypoxia-associated pathways in OSA. Future studies in this model might contribute to the development of targeted strategies against OSA-induced, secondary cardiovascular disease
Kazakhstan Gulag heritage: dark tourism and selective interpretation
Kazakhstan holds some of the most significant Gulag heritage sites; however, tourism research remains limited. This article introduces analysis of contrasting sites and considers how some have been developed and others ignored. Selectivity in interpretation is linked to societal amnesia and the collective trauma experienced by the population of Kazakhstan. The article reaffirms the politicization of heritage in this emergent nation
Symmetry and topology in antiferromagnetic spintronics
Antiferromagnetic spintronics focuses on investigating and using
antiferromagnets as active elements in spintronics structures. Last decade
advances in relativistic spintronics led to the discovery of the staggered,
current-induced field in antiferromagnets. The corresponding N\'{e}el
spin-orbit torque allowed for efficient electrical switching of
antiferromagnetic moments and, in combination with electrical readout, for the
demonstration of experimental antiferromagnetic memory devices. In parallel,
the anomalous Hall effect was predicted and subsequently observed in
antiferromagnets. A new field of spintronics based on antiferromagnets has
emerged. We will focus here on the introduction into the most significant
discoveries which shaped the field together with a more recent spin-off
focusing on combining antiferromagnetic spintronics with topological effects,
such as antiferromagnetic topological semimetals and insulators, and the
interplay of antiferromagnetism, topology, and superconductivity in
heterostructures.Comment: Book chapte
Dynamic Diagnosis of Familial Prion Diseases Supports the β2-α2 Loop as a Universal Interference Target
[Background]
Mutations in the cellular prion protein associated to familial prion disorders severely increase the likelihood of its misfolding into pathogenic conformers. Despite their postulation as incompatible elements with the native fold, these mutations rarely modify the native state structure. However they variably have impact on the thermodynamic stability and metabolism of PrPC and on the properties of PrPSc aggregates. To investigate whether the pathogenic mutations affect the dynamic properties of the HuPrP(125-229) α-fold and find possible common patterns of effects that could help in prophylaxis we performed a dynamic diagnosis of ten point substitutions.[Methodology/Principal Findings]
Using all-atom molecular dynamics simulations and novel analytical tools we have explored the effect of D178N, V180I, T183A, T188K, E196K, F198S, E200K, R208H, V210I and E211Q mutations on the dynamics of HuPrP(125-228) α-fold. We have found that while preserving the native state, all mutations produce dynamic changes which perturb the coordination of the α2-α3 hairpin to the rest of the molecule and cause the reorganization of the patches for intermolecular recognition, as the disappearance of those for conversion inhibitors and the emergence of an interaction site at the β2-α2 loop region.[Conclusions/Significance]
Our results suggest that pathogenic mutations share a common pattern of dynamical alterations that converge to the conversion of the β2-α2 loop into an interacting region that can be used as target for interference treatments in genetic diseases.This work was supported in parts by grants BFU2009-07971 from the MICINN (MG), FundaciÃ3n Cien (MG); Fondazione Cariplo (GC) and AIRC (GC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding received for this study.Peer reviewe
Experimental signatures of the mixed axial-gravitational anomaly in the Weyl semimetal NbP
Weyl semimetals are materials where electrons behave effectively as a kind of
massless relativistic particles known asWeyl fermions. These particles occur in
two flavours, or chiralities, and are subject to quantum anomalies, the
breaking of a conservation law by quantum fluctuations. For instance, the
number of Weyl fermions of each chirality is not independently conserved in
parallel electric and magnetic field, a phenomenon known as the chiral anomaly.
In addition, an underlying curved spacetime provides a distinct contribution to
a chiral imbalance, an effect known as the mixed axial-gravitational anomaly,
which remains experimentally elusive. However, the presence of a mixed
gauge-gravitational anomaly has recently been tied to thermoelectrical
transport in a magnetic field, even in flat spacetime, opening the door to
experimentally probe such type of anomalies in Weyl semimetals. Using a
temperature gradient, we experimentally observe a positive longitudinal
magnetothermoelectric conductance (PMTC) in the Weyl semimetal NbP for
collinear temperature gradients and magnetic fields (DT || B) that vanishes in
the ultra quantum limit. This observation is consistent with the presence of a
mixed axial-gravitational anomaly. Our work provides clear experimental
evidence for the existence of a mixed axial-gravitational anomaly of Weyl
fermions, an outstanding theoretical concept that has so far eluded
experimental detection
Quantum tricritical points in NbFe2
Quantum critical points (QCPs) emerge when a 2nd order phase transition is
suppressed to zero temperature. In metals the quantum fluctuations at such a
QCP can give rise to new phases including unconventional superconductivity.
Whereas antiferromagnetic QCPs have been studied in considerable detail
ferromagnetic (FM) QCPs are much harder to access. In almost all metals FM QCPs
are avoided through either a change to 1st order transitions or through an
intervening spin-density-wave (SDW) phase. Here, we study the prototype of the
second case, NbFe. We demonstrate that the phase diagram can be modelled
using a two-order-parameter theory in which the putative FM QCP is buried
within a SDW phase. We establish the presence of quantum tricritical points
(QTCPs) at which both the uniform and finite susceptibility diverge. The
universal nature of our model suggests that such QTCPs arise naturally from the
interplay between SDW and FM order and exist generally near a buried FM QCP of
this type. Our results promote NbFe as the first example of a QTCP, which
has been proposed as a key concept in a range of narrow-band metals, including
the prominent heavy-fermion compound YbRhSi
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