179 research outputs found
Quantitative measurement of orbital angular momentum in electron microscopy
Electron vortex beams have been predicted to enable atomic scale magnetic
information measurement, via transfer of orbital angular momentum. Research so
far has focussed on developing production techniques and applications of these
beams. However, methods to measure the outgoing orbital angular momentum
distribution are also a crucial requirement towards this goal. Here, we use a
method to obtain the orbital angular momentum decomposition of an electron
beam, using a multi-pinhole interferometer. We demonstrate both its ability to
accurately measure orbital angular momentum distribution, and its experimental
limitations when used in a transmission electron microscope.Comment: 6 pages, 5 figure
Symmetry-constrained electron vortex propagation
Electron vortex beams hold great promise for development in transmission
electron microscopy, but have yet to be widely adopted. This is partly due to
the complex set of interactions that occur between a beam carrying orbital
angular momentum (OAM) and a sample. Herein, the system is simplified to focus
on the interaction between geometrical symmetries, OAM and topology. We present
multiple simulations, alongside experimental data to study the behaviour of a
variety of electron vortex beams after interacting with apertures of different
symmetries, and investigate the effect on their OAM and vortex structure, both
in the far-field and under free-space propagation.Comment: 11 page
Exploiting lens aberrations to create electron vortex beams
A model for a new electron vortex beam production method is proposed and
experimentally demonstrated. The technique calls on the controlled manipulation
of the degrees of freedom of the lens aberrations to achieve a helical phase
front. These degrees of freedom are accessible by using the corrector lenses of
a transmission electron microscope. The vortex beam is produced through a
particular alignment of these lenses into a specifically designed astigmatic
state and applying an annular aperture in the condensor plane. Experimental
results are found to be in good agreement with simulations.Comment: 5 pages, 4 figure
Theory and applications of free-electron vortex states
Both classical and quantum waves can form vortices: with helical phase fronts
and azimuthal current densities. These features determine the intrinsic orbital
angular momentum carried by localized vortex states. In the past 25 years,
optical vortex beams have become an inherent part of modern optics, with many
remarkable achievements and applications. In the past decade, it has been
realized and demonstrated that such vortex beams or wavepackets can also appear
in free electron waves, in particular, in electron microscopy. Interest in
free-electron vortex states quickly spread over different areas of physics:
from basic aspects of quantum mechanics, via applications for fine probing of
matter (including individual atoms), to high-energy particle collision and
radiation processes. Here we provide a comprehensive review of theoretical and
experimental studies in this emerging field of research. We describe the main
properties of electron vortex states, experimental achievements and possible
applications within transmission electron microscopy, as well as the possible
role of vortex electrons in relativistic and high-energy processes. We aim to
provide a balanced description including a pedagogical introduction, solid
theoretical basis, and a wide range of practical details. Special attention is
paid to translate theoretical insights into suggestions for future experiments,
in electron microscopy and beyond, in any situation where free electrons occur.Comment: 87 pages, 34 figure
Non-compliance with colonoscopy after a positive faecal immunochemical test doubles the risk of dying from colorectal cancer.
The risk of colorectal cancer (CRC) among subjects with a positive faecal immunochemical test (FIT) who do not undergo a colonoscopy is unknown. We estimated whether non-compliance with colonoscopy after a positive FIT is associated with increased CRC incidence and mortality.
The FIT-based CRC screening programme in the Veneto region (Italy) invited persons aged 50 to 69 years with a positive FIT (>20 ”g Hb/g faeces) for diagnostic colonoscopy at an endoscopic referral centre. In this retrospective cohort study, we compared the 10-year cumulative CRC incidence and mortality among FIT positives who completed a diagnostic colonoscopy within the programme (compliers) and those who did not (non-compliers), using the Kaplan-Meier estimator and Cox-Aalen models.
Some 88 013 patients who were FIT positive complied with colonoscopy (males: 56.1%; aged 50-59 years: 49.1%) while 23 410 did not (males: 54.6%; aged 50-59 years: 44.9%).The 10-year cumulative incidence of CRC was 44.7 per 1000 (95% CI, 43.1 to 46.3) among colonoscopy compliers and 54.3 per 1000 (95% CI, 49.9 to 58.7) in non-compliers, while the cumulative mortality for CRC was 6.8 per 1000 (95% CI, 5.9 to 7.6) and 16.0 per 1000 (95% CI, 13.1 to 18.9), respectively. The risk of dying of CRC among non-compliers was 103% higher than among compliers (adjusted HR, 2.03; 95% CI, 1.68 to 2.44).
The excess risk of CRC death among those not completing colonoscopy after a positive faecal occult blood test should prompt screening programmes to adopt effective interventions to increase compliance in this high-risk population
Ectopic thymoma simulating a pericardial cyst
We present a case of a 53 year old man with a thymoma near the pericardium, a rare ectopic localisation of thymoma. A round radiodensity found at the right cardiophrenic angle was initially suspected at the echocardiography to be a pericardial cyst. The diagnosis of thymoma was made only after histopathological examination of the surgically re-sected lesion
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review
We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guérin (BCG). Diagnosis was based on positive polymerase chain reaction (PCR) for mycobacterium tuberculosis complex in bronchoalveolar lavage and on the finding on transbronchial biopsy of non necrotising granulomas histopathologically similar to the granulomas found in bladder biopsies. These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review
We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guérin (BCG). Diagnosis was based on positive polymerase chain reaction (PCR) for mycobacterium tuberculosis complex in bronchoalveolar lavage and on the finding on transbronchial biopsy of non necrotising granulomas histopathologically similar to the granulomas found in bladder biopsies. These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies
Prognostic Value of the Fibrosis-4 Index in Human Immunodeficiency Virus Type-1 Infected Patients Initiating Antiretroviral Therapy with or without Hepatitis C Virus
Objective: To evaluate the Fibrosis (FIB)-4 index as a predictor of major liver-related events (LRE) and liver-related death (LRD) in human immunodeficiency virus (HIV) type-1 patients initiating combination antiretroviral therapy (cART). Design: Retrospective analysis of a prospective cohort study. Setting: Italian HIV care centers participating to the ICONA Foundation cohort. Participants: Treatment-naive patients enrolled in ICONA were selected who: initiated cART, had hepatitis C virus (HCV) serology results, were HBsAg negative, had an available FIB-4 index at cART start and during follow up. Methods: Cox regression models were used to determine the association of FIB4 with the risk of major LRE (gastrointestinal bleeding, ascites, hepatic encephalopathy, hepato-renal syndrome or hepatocellular carcinoma) or LRD. Results: Three-thousand four-hundred seventy-five patients were enrolled: 73.3% were males, 27.2% HCV seropositive. At baseline (time of cART initiation) their median age was 39 years, had a median CD4+ T cell count of 260 cells/uL, and median HIV RNA 4.9 log copies/ mL, 65.9% had a FIB-4 < 1.45, 26.4% 1.45-3.25 and 7.7% > 3.25. Over a follow up of 18,662 person-years, 41 events were observed: 25 major LRE and 16 LRD (incidence rate, IR, 2.2 per 1,000 PYFU [95% confidence interval, CI 1.6-3.0]). IR was higher in HCV seropositives as compared to negatives (5.9 vs 0.5 per 1,000 PYFU). Higher baseline FIB-4 category as compared to < 1.45 (FIB-4 1.45-3.25: HR 3.55, 95% CI 1.09-11.58; FIB-4 > 3.25: HR 4.25, 1.21-14.92) and time-updated FIB-4 (FIB-4 1.45-3.25: HR 3.40, 1.02-11.40; FIB- 4> 3.25: HR 21.24, 6.75-66.84) were independently predictive of major LRE/LRD, after adjusting for HIV- and HCV-related variables, alcohol consumption and type of cART. Conclusions: The FIB-4 index at cART initiation, and its modification over time are risk factors for major LRE or LRD, independently of infection with HCV and could be used to monitor patients on cART
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