1,209 research outputs found
Pattern formation in oscillatory complex networks consisting of excitable nodes
Oscillatory dynamics of complex networks has recently attracted great
attention. In this paper we study pattern formation in oscillatory complex
networks consisting of excitable nodes. We find that there exist a few center
nodes and small skeletons for most oscillations. Complicated and seemingly
random oscillatory patterns can be viewed as well-organized target waves
propagating from center nodes along the shortest paths, and the shortest loops
passing through both the center nodes and their driver nodes play the role of
oscillation sources. Analyzing simple skeletons we are able to understand and
predict various essential properties of the oscillations and effectively
modulate the oscillations. These methods and results will give insights into
pattern formation in complex networks, and provide suggestive ideas for
studying and controlling oscillations in neural networks.Comment: 15 pages, 7 figures, to appear in Phys. Rev.
Noise Induced Coherence in Neural Networks
We investigate numerically the dynamics of large networks of globally
pulse-coupled integrate and fire neurons in a noise-induced synchronized state.
The powerspectrum of an individual element within the network is shown to
exhibit in the thermodynamic limit () a broadband peak and an
additional delta-function peak that is absent from the powerspectrum of an
isolated element. The powerspectrum of the mean output signal only exhibits the
delta-function peak. These results are explained analytically in an exactly
soluble oscillator model with global phase coupling.Comment: 4 pages ReVTeX and 3 postscript figure
Event-driven simulations of a plastic, spiking neural network
We consider a fully-connected network of leaky integrate-and-fire neurons
with spike-timing-dependent plasticity. The plasticity is controlled by a
parameter representing the expected weight of a synapse between neurons that
are firing randomly with the same mean frequency. For low values of the
plasticity parameter, the activities of the system are dominated by noise,
while large values of the plasticity parameter lead to self-sustaining activity
in the network. We perform event-driven simulations on finite-size networks
with up to 128 neurons to find the stationary synaptic weight conformations for
different values of the plasticity parameter. In both the low and high activity
regimes, the synaptic weights are narrowly distributed around the plasticity
parameter value consistent with the predictions of mean-field theory. However,
the distribution broadens in the transition region between the two regimes,
representing emergent network structures. Using a pseudophysical approach for
visualization, we show that the emergent structures are of "path" or "hub"
type, observed at different values of the plasticity parameter in the
transition region.Comment: 9 pages, 6 figure
Dynamic range in the C.elegans brain network
We study external electrical perturbations and their responses in the brain dynamic network of the Caenorhabditis eleganssoil worm, given by the connectome of its large somatic nervous system. Our analysis is inspired by a realistic experiment where one stimulates externally specific parts of the brain and studies the persistent neural activity triggered in other cortical regions. In this work, we perturb groups of neurons that form communities, identified by the walktrap community detection method, by trains of stereotypical electrical Poissonian impulses and study the propagation of neural activity to other communities by measuring the corresponding dynamic ranges and Steven law exponents. We show that when one perturbs specific communities, keeping the rest unperturbed, the external stimulations are able to propagate to some of them but not to all. There are also perturbations that do not trigger any response. We found that this depends on the initially perturbed community. Finally, we relate our findings for the former cases with low neural synchronization, self-criticality, and large information flow capacity, and interpret them as the ability of the brainnetwork to respond to external perturbations when it works at criticality and its information flow capacity becomes maximal
Supervised Learning in Multilayer Spiking Neural Networks
The current article introduces a supervised learning algorithm for multilayer
spiking neural networks. The algorithm presented here overcomes some
limitations of existing learning algorithms as it can be applied to neurons
firing multiple spikes and it can in principle be applied to any linearisable
neuron model. The algorithm is applied successfully to various benchmarks, such
as the XOR problem and the Iris data set, as well as complex classifications
problems. The simulations also show the flexibility of this supervised learning
algorithm which permits different encodings of the spike timing patterns,
including precise spike trains encoding.Comment: 38 pages, 4 figure
Triggering up states in all-to-all coupled neurons
Slow-wave sleep in mammalians is characterized by a change of large-scale
cortical activity currently paraphrased as cortical Up/Down states. A recent
experiment demonstrated a bistable collective behaviour in ferret slices, with
the remarkable property that the Up states can be switched on and off with
pulses, or excitations, of same polarity; whereby the effect of the second
pulse significantly depends on the time interval between the pulses. Here we
present a simple time discrete model of a neural network that exhibits this
type of behaviour, as well as quantitatively reproduces the time-dependence
found in the experiments.Comment: epl Europhysics Letters, accepted (2010
Competing synapses with two timescales: a basis for learning and forgetting
Competitive dynamics are thought to occur in many processes of learning
involving synaptic plasticity. Here we show, in a game theory-inspired model of
synaptic interactions, that the competition between synapses in their weak and
strong states gives rise to a natural framework of learning, with the
prediction of memory inherent in a timescale for `forgetting' a learned signal.
Among our main results is the prediction that memory is optimized if the weak
synapses are really weak, and the strong synapses are really strong. Our work
admits of many extensions and possible experiments to test its validity, and in
particular might complement an existing model of reaching, which has strong
experimental support.Comment: 7 pages, 3 figures, to appear in Europhysics Letter
Adherent carbon film deposition by cathodic arc with implantation
A method of improving the adhesion of carbon thin films deposited using a cathodic vacuum arc by the use of implantation at energies up to 20 keV is described. A detailed analysis of carbon films deposited onto silicon in this way is carried out using complementary techniques of transmission electron microscopy and x-ray photoelectron spectroscopy (XPS) is presented. This analysis shows that an amorphous mixing layer consisting of carbon and silicon is formed between the grown pure carbon film and the crystalline silicon substrate. In the mixing layer, it is shown that some chemical bonding occurs between carbon and silicon. Damage to the underlying crystalline silicon substrate is observed and believed to be caused by interstitial implanted carbon atoms which XPS shows are not bonded to the silicon. The effectiveness of this technique is confirmed by scratch testing and by analysis with scanning electron microscopy which shows failure of the silicon substrate occurs before delamination of the carbon film
Recommended from our members
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma.
PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to evaluate safety, pharmacokinetics (PK), and activity. Fluorodeoxyglucose-PET (FDG-PET) was performed to measure metabolic responses.ResultsForty-seven heavily pretreated patients enrolled in eight cohorts (2-65 mg). Dose-limiting toxicities included 1 case of grade 2 bradycardia and grade 3 myocardial ischemia (15 mg), grade 3 stomatitis (45 mg), and 2 cases of grade 3 mucosal inflammation (65 mg); the MTD was 45 mg/day. GDC-0084 demonstrated linear and dose-proportional PK, with a half-life (∼19 hours) supportive of once-daily dosing. At 45 mg/day, steady-state concentrations exceeded preclinical target concentrations producing antitumor activity in xenograft models. FDG-PET in 7 of 27 patients (26%) showed metabolic partial response. At doses ≥45 mg/day, a trend toward decreased median standardized uptake value in normal brain was observed, suggesting central nervous system penetration of drug. In two resection specimens, GDC-0084 was detected at similar levels in tumor and brain tissue, with a brain tissue/tumor-to-plasma ratio of >1 and >0.5 for total and free drug, respectively. Best overall response was stable disease in 19 patients (40%) and progressive disease in 26 patients (55%); 2 patients (4%) were nonevaluable.ConclusionsGDC-0084 demonstrated classic PI3K/mTOR-inhibitor related toxicities. FDG-PET and concentration data from brain tumor tissue suggest that GDC-0084 crossed the blood-brain barrier
Relating a reified adaptive network’s emerging behaviour based on hebbian learning to its reified network structure
- …