Aversion to Loss and Information Overload: An Experimental Investigation

The negative consequences of information overload are well understood across a range of disciplines even though the causative factors that contribute to it have not been coherently researched. We apply the concept of ‘aversion to loss’ from prospect theory and explore its effects in the context of information processing for decision making. A controlled laboratory experiment was performed to test the hypothesis that humans acquire and process relatively more information under the threat of information unavailability. Our results indicate strong support for the hypothesis. Further, we show that despite processing more information, people are less satisfied with their decisions than those who have free and continuous access to information. Implications and extensions of the study are presented

FQHE interferometers in strong tunneling regime. The role of compactness of edge fields

We consider multiple-point tunneling in the interferometers formed between edges of electron liquids with in general different filling factors in the regime of the Fractional Quantum Hall effect (FQHE). We derive an effective matrix Caldeira-Leggett models for the multiple tunneling contacts connected by the chiral single-mode FQHE edges. It is shown that the compactness of the Wen- Fr\"ohlich chiral boson fields describing the FQHE edge modes plays a crucial role in eliminating the spurious non-locality of the electron transport properties of the FQHE interferometers arising in the regime of strong tunneling.Comment: 5 page

Tumors in von Hippel–Lindau Syndrome: From Head to Toe—Comprehensive State-of-the-Art Review

Von Hippel–Lindau syndrome (VHL) is an autosomal-dominant hereditary tumor disease that arises owing to germline mutations in the VHL gene, located on the short arm of chromosome 3. Patients with VHL may develop multiple benign and malignant tumors involving various organ systems, including retinal hemangioblastomas (HBs), central nervous system (CNS) HBs, endolymphatic sac tumors, pancreatic neuroendocrine tumors, pancreatic cystadenomas, pancreatic cysts, clear cell renal cell carcinomas, renal cysts, pheochromocytomas, paragangliomas, and epididymal and broad ligament cystadenomas. The VHL/hypoxia-inducible factor pathway is believed to play a key role in the pathogenesis of VHL-related tumors. The diagnosis of VHL can be made clinically when the characteristic clinical history and findings have manifested, such as the presence of two or more CNS HBs. Genetic testing for heterozygous germline VHL mutation may also be used to confirm the diagnosis of VHL. Imaging plays an important role in the diagnosis and surveillance of patients with VHL. Familiarity with the clinical and imaging manifestations of the various VHL-related tumors is important for early detection and guiding appropriate management. The purpose of this article is to discuss the molecular cytogenetics and clinical manifestations of VHL, review the characteristic multimodality imaging features of the various VHL-related tumors affecting multiple organ systems, and discuss the latest advances in management of VHL, including current recommendations for surveillance and screening

Breeding French Bean (Phaseolus vulgaris L.) for Resistance to Rust (Uromyces phaseoli Reben Wint.)

French bean is an important legume vegetable grown for its tender, green pods for both fresh consumption and processing. Rust, caused by Uromyces phaseoli, limits successful cultivation of this crop. Popular varieties like Contender, Pant Anupama, Pusa Parvathi, Arka Komal, Arka Suvidha, etc., are susceptible to this disease. The french bean variety, Arka Bold, having resistance to rust was used in hybridization with Arka Komal, a popular bush variety with high yield and slender, long green pods but susceptible to rust. Inheritance studies indicated that resistance to rust was controlled by a single, dominant gene. Pedigree method of breeding was followed for incorporating rust resistance in to commercially cultivated varieties. Breeding lines with resistance to rust were selected to F2 generation onwards. These were advanced up to F7, wherein, a promising line, (Arka Bold x Arka Komal) 99-17-2-1-4-12-3, with resistance to rust with high pod yield and good pod quality was selected and named Arka Anoop and released for commercial cultivation

MRI texture analysis parameters of contrast-enhanced T1-weighted images of Crohn's disease differ according to the presence or absence of histological markers of hypoxia and angiogenesis

PURPOSE: To investigate if texture analysis parameters of contrast-enhanced MRI differ according to the presence of histological markers of hypoxia and angiogenesis in Crohn's disease (CD). METHODS: Seven CD patients (mean age 38 (19-75), 3 male)) undergoing ileal resection underwent 3T MR enterography including axial ultrafast spoiled gradient-echo T1 post IV gadolinium chelate. Regions of interest were placed in bowel destined for resection and registered to trans-mural histological sections (n = 28 across 7 bowel sections) via MRI of the resected specimen. Microvessel density (MVD) and staining for markers of hypoxia (HIF 1α) and angiogenesis (VEGF) were performed. Texture analysis features were derived utilizing an image filtration-histogram technique at spatial scaling factor (SSF) 0-6 mm, including mean, standard deviation, mean of positive pixels, entropy, kurtosis and skewness and compared according to the presence or absence of histological markers of hypoxia/angiogenesis using Mann-Whitney U/Kruskal-Wallis tests and with the log of MVD using simple linear regression. RESULTS: Mean, standard deviation and mean of positive pixels were significantly lower in sections expressing VEGF. For example at SSF 6 mm, median (inter-quartile range) of mean, standard deviation and mean of positive pixels in those with VEGF expression were 150.1 (134.7), 132.4 (49.2) and 184.0 (91.4) vs. 362.5 (150.2), 216.3 (100.1) and 416.6 (80.0) in those without (p = 0.001, p = 0.004 and p = 0.001), respectively. There was a significant association between skewness and MVD (ratio 1.97 (1.15-3.41)) at SSF = 2 mm. CONCLUSIONS: Contrast-enhanced MRI texture analysis features significantly differ according to the presence or absence of histological markers of hypoxia and angiogenesis in CD

How Accurate is the Use of Contralateral Implant Size as a Template in Bilateral Hemiarthroplasty?

Purpose Accurately predicting implant size for hemiarthroplasties offers an important contribution to theatre efficiency and patients’ intraoperative care. However, pre-operative sizing using templating of implants in hip fracture patients requiring a hemiarthroplasty is often difficult due to non-standard radiographs, absence of a calibration marker, poor marker placement, variable patient position, and in many institutions a lack of templating facilities. In patients who have previously undergone a hemiarthroplasty on the contralateral side, surgeons can use the contralateral implant size for pre-operative planning purposes. However, the accuracy of doing this has not previously been reported. The aim of this study was to investigate the reliability of using an in situ contralateral implant as a predictor of implant size on the contralateral side. Methods A retrospective review of our local neck of femur fracture (NOF) database was undertaken to identify patients who had bilateral hip hemiarthroplasty. Operative records were reviewed to establish the size of prostheses used at operation. Correlation, agreement, and reliability analysis were performed using the least squares, Bland–Altman plot, and intra-class correlation coefficient (ICC) methods, respectively. Results Operative records were identified for 45 patients who had bilateral hemiarthroplasties. There was a difference in implant size used in 58% of cases. Of these 77% required a larger implant on the right. Implant sizes were within 1 mm of the contralateral side in 78% and within 2 mm in 91% of patients. However, in 9% of patients, there was a discrepancy greater than 2 mm with some cases having up to 6 mm discrepancy. Correlation coefficient was 0.83 and the ICC 0.90. Conclusions The findings in this study indicated that using the size of a contralateral implant can be used as a reliable indicator of head size in cases of bilateral hemiarthroplasty. However, the surgeon should remain cautious as there is a one in ten chance of there being a 3 mm or more difference in implant size

Modernized IRNSS Broadcast Ephemeris Parameters

India has successfully stepped into satellite Navigation system with the launch of its first three IRNSS satellites IRNSS 1A, 1B and 1C.  IRNSS provides two types of services, Standard Posting Service (SPS), which is open for civilian use and the Restricted Service (RS), for authorized users.  The system is set to change the facet of navigation, surveying, transportation, precision agriculture, disaster management and telecommunication in India. In any navigation system, broadcast navigation parameters are of paramount importance in arriving user position solution at user receiver end. IRNSS Navigation data is classified as primary and secondary Navigation parameters. Primary navigation data of a satellite principally represents its own orbit and onboard clock offset in the form of quasi-keplerian elements and clock coefficients (Bias, Drift and Drifts rate) respectively. Whereas secondary navigation parameters includes satellite almanac, ionosphere delay correction messages, differential corrections, Earth orientation parameters and  IRNSS Time offset with respect to other GNSS. In existing IRNSS system satellite ephemeris of primary navigation parameters are broadcast in the form of 15 quasi-keplerian elements valid for a period of 2 hours or more. Spacecraft ephemeris which represents orbit in the form of 9 parameters, i.e., position, velocity and acceleration component of spacecraft in Cartesian coordinate system are chosen from Russian Global Navigation satellite system (Glonass) to improve Time to First Fix (TTFF) of IRNSS system with similar existing orbit accuracy. In addition, two models of user receiver orbit propagation algorithms with proposed ephemeris are briefed and their results are compared with standalone Glonass model. Generation of IRNSS ephemeris in Cartesian coordinate system and description of user receiver orbit propagation algorithms using new type of ephemeris to get user position solution is the scope of this paper.. Keywords: IRNSS, TTFF (Time to First Fix), Broadcast ephemeri