Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development.

The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombomodulin.thrombin complex. Deletion of the EPCR gene in mice has been reported to lead to embryonic lethality before embryonic day 10 (E10.0). To identify potential mechanisms responsible for this lethality, we performed an immunohistological analysis of EPCR distribution during mouse embryogenesis. EPCR was detected in the trophoblast giant cells at the feto-maternal boundary from E7.5 and at later time points in the trophoblasts of the placenta, suggesting a role in the haemostatic regulation of the maternal blood that irrigates these surfaces. In the embryo, EPCR was weakly detected in aortic endothelial cells from E13.5. Thereafter, EPCR levels increased in certain large blood vessels endothelial cells suggesting that the specificity of EPCR to large vessels is conferred in utero. However, not until postnatal day 7 did the intensity and distribution of EPCR staining mimic that observed in adult mice

Deflected jet experiments in a turbulent combustor flowfield

Experiments were conducted to characterize the time-mean and turbulent flow field of a deflected turbulent jet in a confining cylindrical crossflow. Jet-to-crossflow velocity ratios of 2, 4, and 6 were investigated, under crossflow inlet swirler vane angles of 0 (swirler removed), 45 and 70 degrees. Smoke, neutrally buoyant helium-filled soap bubbles, and multi-spark flow visualization were employed to highlight interesting features of the deflected jet, as well as the tracjectory and spread pattern of the jet. A six-position single hot-wire technique was used to measure the velocities and turbulent stresses in nonswirling crossflow cases. In these cases, measurements confirmed that the deflected jet is symmetrical about the vertical plan passing through the crossflow axis, and the jet penetration was found to be reduced from that of comparable velocity ratio infinite crossflow cases. In the swirling crossflow cases, the flow visualization techniques enabled gross flow field characterization to be obtained for a range of lateral jet-to-crossflow velocity ratios and a range of inlet swirl strengths in the main flow

Edging your bets: advantage play, gambling, crime and victimisation

Consumerism, industrial development and regulatory liberalisation have underpinned the ascendance of gambling to a mainstream consumption practice. In particular, the online gambling environment has been marketed as a site of ‘safe risks’ where citizens can engage in a multitude of different forms of aleatory consumption. This paper offers a virtual ethnography of an online ‘advantage play’ subculture. It demonstrates how advantage players have reinterpreted the online gambling landscape as an environment saturated with crime and victimisation. In this virtual world, advantage play is no longer simply an instrumental act concerned with profit accumulation to finance consumer desires. Rather, it acts as an opportunity for individuals to engage in a unique form of edgework, whereby the threat to one’s well-being is tested through an ability to avoid crime and victimisation. This paper demonstrates how mediated environments may act as sites for edgeworking and how the potential for victimisation can be something that is actively engaged with

Enhancing Collaborative Group Processes to Promote Academic Literacy and Content Learning for Diverse Learners Through Video Reflection

Research indicates the benefits of collaborative learning for supporting academic literacy in content classrooms, especially for diverse and exceptional students such as students with learning disabilities or English learners (ELs) who can become disengaged in content classrooms if they struggle to access complex, content-related texts. Drawing from Cognitive Load Theory, we argue that collaborative group structures support students in sharing the load of processing these texts across all members, thus ensuring better comprehension of the content. Yet, collaborative structures may not be beneficial to diverse and exceptional learners in the group, particularly if students are not supported in how to engage successfully in collaborative work. Using a mixed-methods approach, we explored the use of video reflection and guided discussions with students using collaborative strategic reading (CSR) in heterogeneous collaborative groups in one seventh-grade general education, social studies class in an urban middle school. Students’ collaborative group work was video recorded pre- and post-reflection sessions to determine change in engagement in shared learning. The reflection session included students watching the video recording of their group work during CSR, discussing their collaboration using guided prompts, and setting goals for improvement. Following the reflection session, findings revealed an overall increase in time on task for all students, with increased participation of diverse and exceptional students in richer content-related discussions. When all students understand how the collaborative group shares the cognitive load and supports each other through discussing and elaborating on ideas, academic literacy and richer understanding of the content can occur

The Dynamics of D-3-brane Dyons and Toric Hyper-K\"ahler manifolds

We find the dyonic worldvolume solitons due to parallel (p,q) strings ending on a D-3-brane. These solutions preserve 1/4 of bulk supersymmetry. Then we investigate the scattering of well-separated dyons and find that their moduli space is a toric hyper-K\"ahler manifold. In addition, we present the worldvolume solitons of the D-3-brane which are related by duality to the M-theory configuration of two orthogonal membranes ending on a M-5-brane. We show that these solitons preserve 1/8 of supersymmetry and compute their effective action.Comment: 25 pages, phyzz

The Effects of an Intensive Format of the Landreth Filial Therapy Training Model Compared to the Traditional Landreth Filial Therapy Model

This research study investigated the effectiveness of an intensive format of the traditional Landreth filial therapy training (LFTT) model compared to the traditional LFTT model. Specifically, this study compared the intensive LFTT group and the traditional LFTT group at post-testing in the areas of: (a) reducing stress related to parenting, (b) increasing parental empathic behavior with their children, (c) increasing parental acceptance toward their children, and (d) reducing perceived child behavior problems. The traditional LFTT group consisted of 13 parents in groups of up to six members for 10 90-minute weekly sessions. Traditional LFTT involved didactic instruction, required at-home laboratory playtimes, and supervision. Parents were taught child-centered play therapy skills of responsive listening, recognizing children's emotional needs, therapeutic limit setting, building children's self-esteem, and structuring required weekly playtimes with their children using a kit of specially selected toys. The intensive LFTT group consisted of 13 parents in groups of up to four members who met on four Saturdays for 4 hours each. The traditional LFTT model was modified to teach the same material over fewer sessions. The difference in this delivery was fewer opportunities for parents to have home playtimes and receive feedback from the researcher. To compensate for this difference and attempt to maintain the effectiveness of the traditional model, the researcher had parents bring their children to training. The researcher used the parents' children in live demonstrations of the skills being taught. Parents were able to practice the new skills with their own children under direct supervision from the researcher followed by immediate feedback. This modification provided supervision equivalent to that of the traditional LFTT model. The results of this study were no statistically significant differences between the intensive and traditional groups at post-testing on overall parenting stress, parental acceptance and empathic behaviors with their children, and in reported child behavior problems

Quantization of maximally-charged slowly-moving black holes

We discuss the quantization of a system of slowly-moving extreme Reissner-Nordstrom black holes. In the near-horizon limit, this system has been shown to possess an SL(2,R) conformal symmetry. However, the Hamiltonian appears to have no well-defined ground state. This problem can be circumvented by a redefinition of the Hamiltonian due to de Alfaro, Fubini and Furlan (DFF). We apply the Faddeev-Popov quantization procedure to show that the Hamiltonian with no ground state corresponds to a gauge in which there is an obstruction at the singularities of moduli space requiring a modification of the quantization rules. The redefinition of the Hamiltonian a la DFF corresponds to a different choice of gauge. The latter is a good gauge leading to standard quantization rules. Thus, the DFF trick is a consequence of a standard gauge-fixing procedure in the case of black hole scattering.Comment: Corrected errors in the gauge-fixing procedur

Formalism for Multiphoton Plasmon Excitation in Jellium Clusters

We present a new formalism for the description of multiphoton plasmon excitation processes in jellium clusters. By using our method, we demonstrate that, in addition to dipole plasmon excitations, the multipole plasmons (quadrupole, octupole, etc) can be excited in a cluster by multiphoton absorption processes, which results in a significant difference between plasmon resonance profiles in the cross sections for multiphoton as compared to single-photon absorption. We calculate the cross sections for multiphoton absorption and analyse the balance between the surface and volume plasmon contributions to multipole plasmons.Comment: 29 pages, 1 figur

Spacetime diffeomorphisms and the geodesic approximation

We present a spacetime diffeomorphism invariant formulation of the geodesic approximation to soliton dynamics