Aplikasi E-Tour Guide dengan Fitur Pengenalan Image Menggunakan Metode Haar Classifier

Smartphone has became an important instrument in modern society as it is used for entertainment and information searching except for communication. Concerning to this condition, it is needed to develop an application in order to improve smart phone functionality. The objective of this research is to create an application named E-Tour Guide as a tool for helping to plan and manage tourism activity equipped with image recognition feature. Image recognition method used is the Haar Classifier method. The feature is used to recognize historical objects. From the testing result done to 20 images sample, 85% accuracy is achieved for the image recognition feature

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

Background: Patterns of emerging drug resistance reflect the underlying adaptive landscapes for specific drugs. In Plasmodium falciparum, the parasite that causes the most serious form of malaria, antifolate drugs inhibit the function of essential enzymes in the folate pathway. However, a handful of mutations in the gene coding for one such enzyme, dihydrofolate reductase, confer drug resistance. Understanding how evolution proceeds from drug susceptibility to drug resistance is critical if new antifolate treatments are to have sustained usefulness. Methodology/Principal Findings: We use a transgenic yeast expression system to build on previous studies that described the adaptive landscape for the antifolate drug pyrimethamine, and we describe the most likely evolutionary trajectories for the evolution of drug resistance to the antifolate chlorcycloguanil. We find that the adaptive landscape for chlorcycloguanil is multi-peaked, not all highly resistant alleles are equally accessible by evolution, and there are both commonalities and differences in adaptive landscapes for chlorcycloguanil and pyrimethamine. Conclusions/Significance: Our findings suggest that cross-resistance between drugs targeting the same enzyme reflect the fitness landscapes associated with each particular drug and the position of the genotype on both landscapes. The possibl

The surgical treatment of vascular and gastrointestinal implications in Behcet disease

This study reports 4 cases of Behcet Syndrome which came under our observation and were surgically treated for vascular or gastrointestinal manifestations, These cases included 3 males and 1 female, mean age 26.5 years, of which 2 were treated with implantation of prosthesis for aneurysm of the abdominal aorta with recurrence of Behcet vasculitis and prosthesis substitution three years later in one case, I with total colectomy for ulcerous rectocolitis, while the last case (female) required excision and plastic reconstruction, for a perforated duodenal ulcer, Immediate and long-term results of the surgical treatment of the gastrointestinal and vascular manifestations and/or complications were satisfactory, whereas the long-term results of the medical treatment of the basic disease were unsuccessful in 50% of cases, BS is a rare affliction, whose pathogenesis is still poorly defined and in which the results of medical treatment cannot be regarded as satisfactory to date, Surgical treatment of its vascular and gastrointestinal manifestations and complications, on the other hand, was effective in our experience

The surgical treatment of vascular and gastrointestinal implications in Behcet disease. Report of four cases

This study reports 4 cases of Behcet Syndrome which came under our observation and were surgically treated for vascular or gastrointestinal manifestations, These cases included 3 males and 1 female, mean age 26.5 years, of which 2 were treated with implantation of prosthesis for aneurysm of the abdominal aorta with recurrence of Behcet vasculitis and prosthesis substitution three years later in one case, I with total colectomy for ulcerous rectocolitis, while the last case (female) required excision and plastic reconstruction, for a perforated duodenal ulcer, Immediate and long-term results of the surgical treatment of the gastrointestinal and vascular manifestations and/or complications were satisfactory, whereas the long-term results of the medical treatment of the basic disease were unsuccessful in 50% of cases, BS is a rare affliction, whose pathogenesis is still poorly defined and in which the results of medical treatment cannot be regarded as satisfactory to date, Surgical treatment of its vascular and gastrointestinal manifestations and complications, on the other hand, was effective in our experience

Cell therapy for the cardiovascular repair after an induced acute myocardial infarct in a swine animal model.

The Aim of this study was to evaluate the results obtained after one year follow up, with the use of Bone Marrow derived Stromal Cells (BMSCs) and of Human Omentum - derived Fat Stromal Cells (HOFSCs) in the repairing of myocardial infarct in pigs. The BMSCs were harvested from bone marrow collected from ileal crest of pigs while the HOFSCs were obtained from human patients undergoing abdominal surgery. After the isolation the cells were cultured and characterized, were also detected their production of growth factors and cytokines and their angiogenic potential in vitro. After the approval of the Italian Ministery of Health, 30 pigs were enrolled in the study. The myocardial infarct was obtained by a permanent ligation of the inter ventricular artery (IVA). The pigs were divided in three groups: group 1 - treated with BMSCs, group 2 - treated with HOFSCs and group 3 - control group treated with placebo (Saline). In the group 1 and in group 2 after two hours from the ligation of IVA, the cells were injected into the proximal ischemic border zone. After surgery the animals were monitoring periodically by echocardiography, myocardial scintigraphy and cardiac MRI. The animals were euthanized at 3, 6 and 12 months and the hearts were harvested for histological and immunoistochemistry evaluations. In the infarcted area the microvessel density was evaluated using sections labelled for the endothelial markers, In vitro conditions the cells showed the capacity to differentiate into osteogenic, adipogenic and cardiomyogenic cell lineages and were homogeneous for many markers and produce growth factors, cytokines and an high level of angiogenic factors. The instrumental evaluations of the heart functionality (echocardiography, myocardial scintigraphy and cardiac MRI) showed an improvement of myocardial function at 3 months post infarct and a significant decrease of distress symptoms in all pigs treated respect to the control group, but at 6 and at 12 months post infarct they do not give indications of amelioration of the hearts condition and these aspects seemed to be the same to the ones of the control group. The histological examinations at 3 months evidenced, in the treated groups, a reduction of a fibrotic and necrotic tissue and an increment of myogenic, cardyomyogenic and vascular markers that had suggested a better vascularitation and cardiomyogenesis respect to the control group. At 6 and 12 months after the surgery whereas it was possible to observe a major presence of necrotic tissue and an high reduction of cardiomyogenesis with a tickness of the infarcted area and with heart lesions similar to those observed in the control group. The results obtained demonstrated that after a seeming amelioration at the initial stage (3 months) of the anatomical and clinical aspects, the cell therapy at the other interval of time (6 and 12 months) did not induce the expected improvement