679 research outputs found

    Preventing Pneumonia Through Early Mobilization of Critically Ill Adults

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    The purpose of this critically appraised topic (CAT) is to investigate early mobilization and its effect on preventing pneumonia in adults in the intensive care unit (ICU). The final portfolio contains four research articles from both national and international journals. Study designs included two meta-analyses, one case series, and one retrospective study. All four of the articles specifically described the effects of early mobilization on individuals in the hospital and ICU and showed positive results in reducing the likelihood of developing pneumonia. This CAT will be used to draft new practice guidelines for mentoring new managers in both occupational therapy and physical therapy

    Interference effects in isolated Josephson junction arrays with geometric symmetries

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    As the size of a Josephson junction is reduced, charging effects become important and the superconducting phase across the link turns into a periodic quantum variable. Isolated Josephson junction arrays are described in terms of such periodic quantum variables and thus exhibit pronounced quantum interference effects arising from paths with different winding numbers (Aharonov-Casher effects). These interference effects have strong implications for the excitation spectrum of the array which are relevant in applications of superconducting junction arrays for quantum computing. The interference effects are most pronounced in arrays composed of identical junctions and possessing geometric symmetries; they may be controlled by either external gate potentials or by adding/removing charge to/from the array. Here we consider a loop of N identical junctions encircling one half superconducting quantum of magnetic flux. In this system, the ground state is found to be non-degenerate if the total number of Cooper pairs on the array is divisible by N, and doubly degenerate otherwise (after the stray charges are compensated by the gate voltages).Comment: 9 pages, 6 figure

    nu=1/2 quantum Hall effect in the Aharonov-Casher geometry in a mesoscopic ring

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    We study the effect of an electric charge in the middle of a ring of electrons in a magnetic field such as Ξ½=1/2\nu = 1/2. In the absence of the central charge, a residual current should appear due to an Aharanov-Bohm effect. As the charge varies, periodic currents should appear in the ring. We evaluate the amplitude of these currents, as well as their period as the central charge varies. The presence of these currents should be a direct signature of the existence of a statistical gauge field in the Ξ½=1/2\nu=1/2 quantum Hall effect. Numerical diagonalizations for a small number of electrons on the sphere are also carried out. The numerical results up to 9 electrons are qualitatively consistent with the mean field picture.Comment: 23 pages,14 included postscript figures, submitted to Phys. Rev.

    Possible realization of Josephson charge qubits in two coupled Bose-Einstein condensates

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    We demonstrate that two coupled Bose-Einstein condensates (BEC) at zero temperature can be used to realize a qubit which is the counterpart of Josephson charge qubits. The two BEC are weakly coupled and confined in an asymmetric double-well trap. When the "charging energy" of the system is much larger than the Josephson energy and the system is biased near a degeneracy point, the two BEC represent a qubit with two states differing only by one atom. The realization of the BEC qubits in realistic BEC experiments is briefly discussed.Comment: 4 pages; comments are welcome / Corrected typos in Eq. (16); a note adde

    Global Globin Network and adopting genomic variant database requirements for thalassemia

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    \ua9 The Author(s) 2024. Published by Oxford University Press.Thalassemia is one of the most prevalent monogenic disorders in low- and middle-income countries (LMICs). There are an estimated 270 million carriers of hemoglobinopathies (abnormal hemoglobins and/or thalassemia) worldwide, necessitating global methods and solutions for effective and optimal therapy. LMICs are disproportionately impacted by thalassemia, and due to disparities in genomics awareness and diagnostic resources, certain LMICs lag behind high-income countries (HICs). This spurred the establishment of the Global Globin Network (GGN) in 2015 at UNESCO, Paris, as a project-wide endeavor within the Human Variome Project (HVP). Primarily aimed at enhancing thalassemia clinical services, research, and genomic diagnostic capabilities with a focus on LMIC needs, GGN aims to foster data collection in a shared database by all affected nations, thus improving data sharing and thalassemia management. In this paper, we propose a minimum requirement for establishing a genomic database in thalassemia based on the HVP database guidelines. We suggest using an existing platform recommended by HVP, the Leiden Open Variation Database (LOVD) (https://www.lovd.nl/). Adoption of our proposed criteria will assist in improving or supplementing the existing databases, allowing for better-quality services for individuals with thalassemia. Database URL: https://www.lovd.nl/

    Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

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    Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD

    Real-world efficacy of direct acting antiviral therapies in patients with HIV/HCV

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    The advent of direct-acting antiviral (DAA) therapies has dramatically transformed HCV treatment, with most recent trials demonstrating high efficacy rates (>90%) across all genotypes and special populations, including patients with HIV/HCV coinfection. The efficacy rates of HCV treatment are nearly identical between patients with HCV monofection and patients with HIV/HCV coinfection; however, there are limited studies to compare real-world efficacy with efficacy observed in clinical trials. Using a database from HIV clinics across the United States (US), we identified 432 patients with HIV/HCV coinfection who completed DAA therapy from January 1, 2014 to March 31, 2017 and were assessed for efficacy. Efficacy was evaluated as sustained virologic response (SVR) 12 weeks after DAA completion; furthermore, factors associated with achieving SVR12 were identified. In this analysis, we found DAA therapies to be effective, with 94% of the patients achieving SVR12 and 6% experiencing virologic failure. Baseline variables, including older age, HCV viral load <800K IU/ML, FIB-4 score <1.45, absence of depression, diabetes, substance abuse, and use of DAA regimens without ribavirin were significant predictors of achieving SVR12. Patients with fewer comorbidities, better liver health, and lower HCV viral loads at baseline were more likely to achieve treatment success. Our results were consistent with other real-world studies, supporting the use of HCV therapy in HIV/HCV coinfected patients
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