Overview of Plant-Made Vaccine Antigens against Malaria

This paper is an overview of vaccine antigens against malaria produced in plants. Plant-based expression systems represent an interesting production platform due to their reduced manufacturing costs and high scalability. At present, different Plasmodium antigens and expression strategies have been optimized in plants. Furthermore, malaria antigens are one of the few examples of eukaryotic proteins with vaccine value expressed in plants, making plant-derived malaria antigens an interesting model to analyze. Up to now, malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice. Therefore, plant production platforms offer wonderful prospects for improving the access to malaria vaccines

A highly efficient simulation technique for piezoelectric energy harvesters

This paper presents a new numerical technique which is aimed at obtaining fast and accurate simulations of piezoelectric beams, used in inertial energy harvesting MEMS. The execution of numerical analyses is greatly important in order to predict the actual behaviour of MEMS device and to carry out the optimization process on the basis of Design of Experiments (DOE) techniques. In this paper, a refined, yet simple, model is proposed with reference to the multi-physics problem of piezoelectric energy harvesting by means of laminate cantilevers. The proposed model is calibrated and validated with reference to 3D finite element analyses

Special Article: Physical Activity, Physical Fitness, and Cardiovascular Risk Factors in Childhood

In adults, physical activity and exercise training are associated with reduced cardiovascular morbidity and mortality, a reduced likelihood of developing adverse cardiovascular risk factors, and improved insulin sensitivity. In childhood, participation in appropriate physical activity may prevent the development of cardiovascular risk factors in the future and complement treatment of existing cardiovascular risk factors, including hypertension, dyslipidemia, and overweight. Exercise in children can also significantly improve insulin sensitivity independent of weight loss. These e fects are mediated in overweight children by increases in lean body mass relative to fat mass and associated improvements in inflammatory mediators, endothelial function, and the associated adverse hormonal milieu

Intermediate temperature solid oxide fuel cell/electrolyzer towards future large-scale production

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Preliminary design of AR/SOFC cogeneration energy system using livestock waste

Abstract This paper reports on a sizing procedure for integrated Anaerobic Reactor/Solid Oxide Fuel Cell cogeneration energy system powered by livestock waste, in order to meet the provisions of Industry 4.0, connected to the new paradigm of Agriculture 4.0. The algorithm accounts on two main computational blocks, associated to the biogas production plant and to the SOFC energy unit respectively. A numerical modeling is performed to dimension the anaerobic digester and the biogas production deriving, as well as to dimension the energy unit and determine its techno-energy performance when it is fed by the previous biogas. An application of the algorithm is made to a mid-size livestock farm, in order to valorize the biomass waste produced in situ

On the application of piezolaminated composites to diaphragm micropumps

This paper deals with the numerical simulation of piezolaminated microplates adopted as actuators in micropumps. The performances of piezoelectric actuation is critically assessed by means of comparisons with devices based on the electrostatic force

Fatigue life prediction of high strength steel welded joints by Energy Approach

AbstractTwo full-field techniques were applied for the study of the base material and welded specimens, made of S690QL steel: digital image correlation and thermographic techniques. Static and fatigue tests were carried out. The thermographic measurements can be used to predict the fatigue, with a great saving in time and effort. Fatigue tests at increasing loads were carried out by a stepwise succession, applied to the same specimen, for applying an energy-based approach. The predictions of the fatigue life, obtained by means of the Energy Approach, were compared with the values obtained by the traditional procedure

A top-down, three-scale numerical analysis of wafer-to-wafer metallic bonding

To study the sensitivity to micro-scale imperfections of the strength of a metallic, wafer-to-wafer MEMS bonding, we propose a three-scale numerical (finite element) approach. At the wafer level (macro-scale), accounting for the whole metallic sealing through nonlinear springs connecting the two silicon wafers modelled as thin plates, we link the force transferred by each single MEMS die to the external pressure applied to the wafers. This force is next used as an index for the input pressure at the die level (meso-scale), where the geometry of the metallic rings is accurately described: the local stress field at the interface between the upper and lower metallic rings is so obtained. Finally, a local (micro-scale) model is used to link the aforementioned local stress field in each die to the bonding strength: representative volumes of the rings getting into contact, accounting in a statistically way for the relevant surface roughness (which is on the order or tens of nanometers at most), are adopted to obtain the relationship between the external pressure and the percentage of sealed area. This information is exploited to assess the properties of the rings, in terms of expected bonding strength

Multiphysics analyses of the effect of package on the performances of PMUT transducers

The paper deals with the multiphysics modeling of piezoelectric micromachined ultrasound transducers (PMUT), that can be used in several practical applications. The model accounts for the multiple couplings between the mechanical fields and the electric and acoustic ones. The numerical solution has been sought by means of the finite element method, for the special case of axial symmetry. The model has been validated with reference to experimental data, that have been obtained by the Authors. The numerical procedure has been applied to carry out a parametric analysis of the effect of package, to extract a set of design guidelines

thermographic analysis during tensile tests and fatigue assessment of s355 steel

Abstract Structural S355 steel is widely applied in various sectors. Fatigue properties are of fundamental importance and extremely time consuming to be assessed. The aim of this research activity is to apply the Static Thermographic Method during tensile tests and correlate the temperature trend to the fatigue properties of the same steel. The Digital Image Correlation (DIC) and Infrared Thermography (IR) techniques have been used during all static tests. The Digital Image Correlation technique allowed the detection of displacements and strain, and so the evaluation of the mechanical properties of the material. Traditional fatigue tests were also performed in order to evaluate the stress-number of cycles to failure curve of the same steel. The value of the fatigue limit, obtained by the traditional procedure, was compared with the values predicted by means of the Static Thermographic Method (STM) obtained from tensile tests. The predicted values are in good agreement with the experimental values of fatigue life